Abstract:Expression of the immediate early gene Arc/Arg3.1 (Arc), a key mediator
of synaptic plasticity, is enhanced by neural activity and then reduced
by proteasome-dependent degradation. We have previously shown that
disruption of Arc degradation, in an Arc knock-in mouse (ArcKR), where
the predominant Arc ubiquitination sites were mutated, reduced the
threshold to induce, and also enhanced, the strength of Group I
metabotropic glutamate receptor-mediated long-term depression
(DHPG-LTD). Here we have investigated if… Show more
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