Arbutin alleviates diabetic symptoms by attenuating oxidative stress in a mouse model of type 1 diabetes

Li, Hui; Cao, Wen; Wei, Lan-Fu; Jun-quan, Xia; Gu, Yi; Gu, Li-Mei; Pan, Cheng-Yu; Liu, Youqian; Tian, Yaozhou; Lü, Min

doi:10.1007/s13410-021-00920-0

Cited by 10 publications

(6 citation statements)

References 19 publications

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“…Figure 8 B shows that most of the immunological target proteins—including CCL4, CXCR4, CXCL12, CXCL8, CXCL10, CXCL1, CXCL11, CXCL5, CCL20, and CXCL2—are centrally located in the PPI networks, with top degrees of interaction, indicating that this PPI network is associated with immunological activities. It has been stated that human chemokines are associated with or implicated in the pathogenesis of type 1 diabetes [ 30 ].…”

Section: Resultsmentioning

confidence: 99%

“…Inflammatory response—the most significant biological process—is documented to be associated with diabetes [ 31 ]. G-protein-coupled receptor signaling pathways are related with the crosstalk with insulin signaling [ 32 ], while chemokines have been found to be associated with or implicated in the pathogenesis of type 1 diabetes [ 30 ]. Type 2 diabetes has broad impact on immune responses [ 33 ].…”

Section: Resultsmentioning

confidence: 99%

“…It was found that the neuroactive ligand–receptor interaction was predicted to be a major modulated pathway in an antidiabetic study [ 34 ]. Chemokines have been associated with or implicated in the pathogenesis of type 1 diabetes [ 30 ], while cytokines are crucial immunotherapeutic targets in diabetes [ 35 ].…”

Section: Resultsmentioning

confidence: 99%

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Pharmacoinformatics and UPLC-QTOF/ESI-MS-Based Phytochemical Screening of Combretum indicum against Oxidative Stress and Alloxan-Induced Diabetes in Long–Evans Rats

Forid

Aluwi

et al. 2021

Molecules

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This research investigated a UPLC-QTOF/ESI-MS-based phytochemical profiling of Combretum indicum leaf extract (CILEx), and explored its in vitro antioxidant and in vivo antidiabetic effects in a Long–Evans rat model. After a one-week intervention, the animals’ blood glucose, lipid profile, and pancreatic architectures were evaluated. UPLC-QTOF/ESI-MS fragmentation of CILEx and its eight docking-guided compounds were further dissected to evaluate their roles using bioinformatics-based network pharmacological tools. Results showed a very promising antioxidative effect of CILEx. Both doses of CILEx were found to significantly (p < 0.05) reduce blood glucose, low-density lipoprotein (LDL), and total cholesterol (TC), and increase high-density lipoprotein (HDL). Pancreatic tissue architectures were much improved compared to the diabetic control group. A computational approach revealed that schizonepetoside E, melianol, leucodelphinidin, and arbutin were highly suitable for further therapeutic assessment. Arbutin, in a Gene Ontology and PPI network study, evolved as the most prospective constituent for 203 target proteins of 48 KEGG pathways regulating immune modulation and insulin secretion to control diabetes. The fragmentation mechanisms of the compounds are consistent with the obtained effects for CILEx. Results show that the natural compounds from CILEx could exert potential antidiabetic effects through in vivo and computational study.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Pharmacoinformatics and UPLC-QTOF/ESI-MS-Based Phytochemical Screening of Combretum indicum against Oxidative Stress and Alloxan-Induced Diabetes in Long–Evans Rats

Forid

Aluwi

et al. 2021

Molecules

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“…Individual phenolic compounds present in vinegar including gallic acid, chlorogenic acid, ferulic acid, caffeic acid, and catechin showed a significant inhibition through binding carbohydrate hydrolyzing enzymes [42]. In addition to phenolic acids, arbutin, glycosylated hydroquinone presented as a predominant bioactive molecule in AAV (32.60%) and IAV (45.58%) has been documented to have in vivo and in vitro antihyperglycemic activity [43,44]. Yousefi and coworkers have reported that arbutin displayed potent α-amylase and α-glucosidase inhibitory action [43].…”

Section: α-Amylase and α-Glucosidasementioning

confidence: 99%

The Nutritional and Antioxidant Potential of Artisanal and Industrial Apple Vinegars and Their Ability to Inhibit Key Enzymes Related to Type 2 Diabetes In Vitro

et al. 2022

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The main objective of the current study was to determine the physicochemical properties, antioxidant activities, and α-glucosidase and α-amylase inhibition of apple vinegar produced by artisanal and industrial methods. Apple vinegar samples were analyzed to identify their electrical conductivity, pH, titratable acidity, total dry matter, Brix, density, mineral elements, polyphenols, flavonoids, and vitamin C. The antioxidant activity of apple vinegar samples was evaluated using two tests, total antioxidant capacity (TAC) and DPPH radical scavenging activity. Finally, we determined α-glucosidase and α-amylase inhibitory activities of artisanal and industrial apple vinegar. The results showed the following values: pH (3.69–3.19); electrical conductivity (2.81–2.79 mS/cm); titratable acidity (3.6–5.4); ash (4.61–2.90); °Brix (6.37–5.2); density (1.02476–1.02012), respectively, for artisanal apple vinegar and industrial apple vinegar. Concerning mineral elements, potassium was the most predominant element followed by sodium, magnesium, and calcium. Concerning bioactive compounds (polyphenols, flavonoids, and vitamin C), the apple vinegar produced by the artisanal method was the richest sample in terms of bioactive compounds and had the highest α-glucosidase and α-amylase inhibition. The findings of this study showed that the quality and biological activities of artisanal apple vinegar were more important than industrial apple vinegar.

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“…Apigenin inhibits the inflammatory response mediated by NF-κB. [ 176 ] HFD/STZ-IDR Decreased insulin resistance and glycaemia content [ 177 ] STZ-IDR Decreased ROS levels Restored β-cell apoptosis [ 178 ] STZ-IDR Improved biochemical parameters Repaired destroyed renal and hepatic architecture Arbutin [ 179 ] Fasting and healthy dogs Reduced glycaemia level [ 180 ] Alloxan (ALX)-IDR Decreased insulin and serum glucose concentrations [ 181 ] ALX-IDR Increased glucagon-like peptide 1 (GLP-1) and GLP1R levels [ 182 ] STZ-induced diabetic mice (IDM) Apigenin inhibited increased blood sugar levels and prevented body weight loss. Apigenin activated antioxidant enzymes such as SOD, CAT, and GPX.…”

Section: In Vivo and In Vitro Anti-diabet...mentioning

confidence: 99%

Clinical applications and mechanism insights of natural flavonoids against type 2 diabetes mellitus

Bouyahya,

Balahbib,

Khalid

et al. 2024

Heliyon

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Arbutin alleviates diabetic symptoms by attenuating oxidative stress in a mouse model of type 1 diabetes

Cited by 10 publications

References 19 publications

Pharmacoinformatics and UPLC-QTOF/ESI-MS-Based Phytochemical Screening of Combretum indicum against Oxidative Stress and Alloxan-Induced Diabetes in Long–Evans Rats

Pharmacoinformatics and UPLC-QTOF/ESI-MS-Based Phytochemical Screening of Combretum indicum against Oxidative Stress and Alloxan-Induced Diabetes in Long–Evans Rats

The Nutritional and Antioxidant Potential of Artisanal and Industrial Apple Vinegars and Their Ability to Inhibit Key Enzymes Related to Type 2 Diabetes In Vitro

Clinical applications and mechanism insights of natural flavonoids against type 2 diabetes mellitus

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