Arbovirus Surveillance from 1990 to 1995 in the Barkedji Area (Ferlo) of Senegal, a Possible Natural Focus of Rift Valley Fever Virus

Traore-Lamizana, Moumouni; Fontenille, Didier; Diallo, Mawlouth; Bâ, Yamar; Zeller, H.; Mondo, Mireille; Adam, F.; Thonon, Jocelyn; Maiga, Abdourahmane

doi:10.1603/0022-2585-38.4.480

Cited by 80 publications

(77 citation statements)

References 44 publications

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“…At a coarse grain, we observed that the Zimbabwe spread viruses during the first half of last century, while Kenya experienced a more intense activity as a hub during the second half. The notion that Barkedji may be an important gateway to RVFV in Senegal and Mauritania was previously suggested by serologic and entomologic surveys [13], [14]. An important role of Barkedji appears to be independently supported by the fact that it is a known crossroad of migration movements of herds between the southern and northern regions of Senegal and, to a larger extent, to southern Mauritania.…”

Section: Resultsmentioning

confidence: 91%

Phylogeography of Rift Valley Fever Virus in Africa Reveals Multiple Introductions in Senegal and Mauritania

et al. 2012

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Rift Valley Fever (RVF) virus (Family Bunyaviridae) is an arthropod-borne RNA virus that infects primarily domestic ruminants and occasionally humans. RVF epizootics are characterized by numerous abortions and mortality among young animals. In humans, the illness is usually characterized by a mild self-limited febrile illness, which could progress to more serious complications. RVF virus is widespread and endemic in many regions of Africa. In Western Africa, several outbreaks have been reported since 1987 when the first major one occurred at the frontier of Senegal and Mauritania. Aiming to evaluate the spreading and molecular epidemiology in these countries, RVFV isolates from 1944 to 2008 obtained from 18 localities in Senegal and Mauritania and 15 other countries were investigated. Our results suggest that a more intense viral activity possibly took place during the last century compared to the recent past and that at least 5 introductions of RVFV took place in Senegal and Mauritania from distant African regions. Moreover, Barkedji in Senegal was possibly a hub associated with the three distinct entries of RVFV in West Africa.

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Section: Resultsmentioning

confidence: 91%

Phylogeography of Rift Valley Fever Virus in Africa Reveals Multiple Introductions in Senegal and Mauritania

et al. 2012

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“…During the rainy season, they move back, thus increasing (in addition to the transhumant farmers from others regions of Senegal) substantially the population size of the livestock. This situation associated with the climatic conditions favourable for local vectors increase the risk of the emergence of vector-borne diseases such as Rift Valley and West Nile fevers that are endemic in this area [6], but might also affect malaria transmission.…”

Section: Introductionmentioning

confidence: 99%

Spatio-temporal analysis of host preferences and feeding patterns of malaria vectors in the sylvo-pastoral area of Senegal: impact of landscape classes

et al. 2013

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BackgroundThe study of vector feeding behaviour is an important step in the understanding of the epidemiology of vector borne diseases. The main objective of this work was to study the spatio-temporal host preferences and blood-feeding patterns of malaria vectors in a pastoral area of Senegal where cattle breeding is the main human activity.MethodsMalaria vectors were collected indoors by pyrethrum spray catch in 16 villages belonging to 4 different landscape classes (wooded savanna, shrubby savanna, bare soils and steppe). Blood meals sources were determined using a direct enzyme-linked immunosorbent assay (ELISA).ResultsThe blood meal origins of 1886 freshly fed An. gambiae s.l. were determined. Among these blood meals, most were taken on a single host: 40.1% on human and 37.1% on animal. The range in proportions of blood meals taken from human were 25–62.4% in wooded savanna villages, 23.5–61.9% in shrubby savanna villages, 31.3–70% in bare soils villages and 57.7–68.7 in steppe villages. Blood meals taken from bovines were very heterogeneous with two clusters localized in the Northeast and Southwest axis of the study area that corresponds to the distribution of the main water ponds. Patent mixed blood meals taken from human and non-human were significantly higher than those taken from two animals, the highest proportions being observed in September (shrubby savanna, bare soils and steppe villages) or October (wooded savanna villages).ConclusionsThese observations suggest that in this pastoral area, differences in feeding patterns of malaria vectors are merely linked to the specific localization of villages and are not influenced by landscape class distribution. In addition, the temporal variations in the anthropophilic rates are influenced by the presence of standing water in the study area.

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“…RVFV could be maintained in an enzootic cycle involving Aedes mosquitoes such as Ae. vexans in West Africa (Fontenille et al 1995, 1998, Zeller et al 1997, Traore-Laminaza et al 2001. Aedes species are able to transmit the virus vertically to their offspring (Linthicum et al 1985(Linthicum et al , 1999.…”

Section: Introductionmentioning

confidence: 99%

Replication of Clone 13, a Naturally Attenuated Avirulent Isolate of Rift Valley Fever Virus, inAedesandCulexmosquitoes

Moutailler

Krida

Madec

et al. 2010

Vector-Borne and Zoonotic Diseases

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Rift Valley fever virus continues to cause large outbreaks of acute and febrile illness among humans and domestic animals in Africa. The high pathogenicity of the virus is mainly due to the non-structural protein derived from the S segment NSs, which was shown to inhibit the type I interferon expression at the transcriptional level and to suppress host cell RNA synthesis. Clone 13, a naturally attenuated clone containing a deletion of 70% in NSs, is a promising vaccine candidate as it has no pathogenicity for mice and is highly immunogenic leading to long-lasting immunity. If Clone 13 succeeds in inducing a transient viremia in inoculated animals, is a mosquito vector able to replicate Clone 13 and is the vector affected by viral infection? In this work, we orally infected two mosquito species, Aedes vexans and Culex pipiens quinquefasciatus, with the avirulent Clone 13. We showed that the mosquito Ae. vexans better replicated the avirulent Clone 13 than Cx. p. quinquefasciatus. Moreover, infection with Clone 13 did not cause any important changes in mosquito's life-history traits compared to noninfected females. Nevertheless, it is likely that Clone 13 would not be efficiently transmitted by mosquito vectors.

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Arbovirus Surveillance from 1990 to 1995 in the Barkedji Area (Ferlo) of Senegal, a Possible Natural Focus of Rift Valley Fever Virus

Cited by 80 publications

References 44 publications

Phylogeography of Rift Valley Fever Virus in Africa Reveals Multiple Introductions in Senegal and Mauritania

Phylogeography of Rift Valley Fever Virus in Africa Reveals Multiple Introductions in Senegal and Mauritania

Spatio-temporal analysis of host preferences and feeding patterns of malaria vectors in the sylvo-pastoral area of Senegal: impact of landscape classes

Replication of Clone 13, a Naturally Attenuated Avirulent Isolate of Rift Valley Fever Virus, inAedesandCulexmosquitoes

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