Arbitrary visuo-motor mapping during object manipulation in mild cognitive impairment and Alzheimer's disease: A pilot study

Ameli, Mitra; Kemper, F.; Sarfeld, Anna-Sophia; Kessler, Josef; Fink, Gereon R.; Nowak, Dennis A.

doi:10.1016/j.clineuro.2011.01.011

Cited by 8 publications

(7 citation statements)

References 38 publications

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Section: Resultsmentioning

confidence: 99%

“…Three studies used tasks involving reach/grasp/lift of an object [ 34 , 55 , 75 ]. In one study [ 34 ], participants with MCI and AD lifted objects with different weights and held them for 4 s. In another [ 55 ], participants with dementia (various types) lifted an object for 20 s. Both studies analysed steadiness and speed. One study [ 75 ] assessed reaching for an object at self-selected and fast paces, under various visual conditions in HC and Parkinson’s Disease (PD), some with cognitive impairment, measuring the time to complete the task.…”

Section: Resultsmentioning

confidence: 99%

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Investigating the associations between upper limb motor function and cognitive impairment: a scoping review

2023

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Upper limb motor function is a potential new biomarker of cognitive impairment and may aid discrimination from healthy ageing. However, it remains unclear which assessments to use. This study aimed to explore what methods have been used and to describe associations between upper limb function and cognitive impairment. A scoping review was conducted using PubMed, CINAHL and Web of Science. A systematic search was undertaken, including synonyms for key concepts ‘upper limb’, ‘motor function’ and ‘cognitive impairment’. Selection criteria included tests of upper limb motor function and impaired cognition in adults. Analysis was by narrative synthesis. Sixty papers published between 1998 and 2022, comprising 41,800 participants, were included. The most common assessment tasks were finger tapping, Purdue Pegboard Test and functional tasks such as writing. Protocols were diverse in terms of equipment used and recording duration. Most participants were recruited from clinical settings. Alzheimer’s Disease was the most common cause of cognitive impairment. Results were mixed but, generally, slower speed, more errors, and greater variability in upper limb movement variables was associated with cognitive impairment. This review maps the upper limb motor function assessments used and summarises the available evidence on how these associate with cognitive impairment. It identifies research gaps and may help guide protocols for future research. There is potential for upper limb motor function to be used in assessments of cognitive impairment.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Investigating the associations between upper limb motor function and cognitive impairment: a scoping review

2023

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“…The slower articulation rate can be the result of slower cognitive processes due to MCI, affecting attention, memory, and language, including word recall and grammar [ 1 – 3 ]. It can also be the result of impaired motor control as patients with MCI are characterized largely by abnormalities in motor coordination and disinhibition [ 54 ], motor preparation [ 55 ], and motor planning [ 56 ], which can influence motoric functions related to articulation.…”

Section: Discussionmentioning

confidence: 99%

Voice quality and speech fluency distinguish individuals with Mild Cognitive Impairment from Healthy Controls

2020

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Mild Cognitive Impairment (MCI) is a syndrome characterized by cognitive decline greater than expected for an individual's age and education level. This study aims to determine whether voice quality and speech fluency distinguish patients with MCI from healthy individuals to improve diagnosis of patients with MCI. We analyzed recordings of the Cookie Theft picture description task produced by 26 patients with MCI and 29 healthy controls from Sweden and calculated measures of voice quality and speech fluency. The results show that patients with MCI differ significantly from HC with respect to acoustic aspects of voice quality, namely H1-A3, cepstral peak prominence, center of gravity, and shimmer; and speech fluency, namely articulation rate and averaged speaking time. The method proposed along with the obtainability of connected speech productions can enable quick and easy analysis of speech fluency and voice quality, providing accessible and objective diagnostic markers of patients with MCI.

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“…Furthermore, increased tapping variability has also been shown in patients with attention deficit hyperactivity disorder ( 50 ). Impaired working memory and attention may compromise matching of internal task expectancies with external temporal demands ( 51 ) or affect task planning ( 52 ) and prediction ( 53 ). Second, subjects with cognitive decline showed reduced ability to select the correct finger according to the visual cue during the multi-finger tapping task (Figure 3C ).…”

Section: Discussionmentioning

confidence: 99%

Manual Dexterity and Aging: A Pilot Study Disentangling Sensorimotor From Cognitive Decline

et al. 2018

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Manual dexterity measures can be useful for early detection of age-related functional decline and for prediction of cognitive decline. However, what aspects of sensorimotor function to assess remains unclear. Manual dexterity markers should be able to separate impairments related to cognitive decline from those related to healthy aging. In this pilot study, we aimed to compare manual dexterity components in patients diagnosed with cognitive decline (mean age: 84 years, N = 11) and in age comparable cognitively intact elderly subjects (mean age: 78 years, N = 11). In order to separate impairments due to healthy aging from deficits due to cognitive decline we also included two groups of healthy young adults (mean age: 26 years, N = 10) and middle-aged adults (mean age: 41 years, N = 8). A comprehensive quantitative evaluation of manual dexterity was performed using three tasks: (i) visuomotor force tracking, (ii) isochronous single finger tapping with auditory cues, and (iii) visuomotor multi-finger tapping. Results showed a highly significant increase in force tracking error with increasing age. Subjects with cognitive decline had increased finger tapping variability and reduced ability to select the correct tapping fingers in the multi-finger tapping task compared to cognitively intact elderly subjects. Cognitively intact elderly subjects and those with cognitive decline had prolonged force release and reduced independence of finger movements compared to young adults and middle-aged adults. The findings suggest two different patterns of impaired manual dexterity: one related to cognitive decline and another related to healthy aging. Manual dexterity tasks requiring updating of performance, in accordance with (temporal or spatial) task rules maintained in short-term memory, are particularly affected in cognitive decline. Conversely, tasks requiring online matching of motor output to sensory cues were affected by age, not by cognitive status. Remarkably, no motor impairments were detected in patients with cognitive decline using clinical scales of hand function. The findings may have consequences for the development of manual dexterity markers of cognitive decline.

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Arbitrary visuo-motor mapping during object manipulation in mild cognitive impairment and Alzheimer's disease: A pilot study

Cited by 8 publications

References 38 publications

Investigating the associations between upper limb motor function and cognitive impairment: a scoping review

Investigating the associations between upper limb motor function and cognitive impairment: a scoping review

Voice quality and speech fluency distinguish individuals with Mild Cognitive Impairment from Healthy Controls

Manual Dexterity and Aging: A Pilot Study Disentangling Sensorimotor From Cognitive Decline

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