Heisenberg's uncertainty principle results in one of the strangest quantum behaviors: an oscillator can never truly be at rest. Even in its lowest energy state, at a temperature of absolute zero, its position and momentum are still subject to quantum fluctuations 1,2 . Resolving these fluctuations using linear position measurements is complicated by the fact that classical noise can masquerade as quantum noise [3][4][5][6] . On the other hand, direct energy detection of the oscillator in its ground state makes it appear motionless 1,7 . So how can we resolve quantum fluctuations? Here, we parametrically couple a micromechanical oscillator to a microwave cavity to prepare the system in its quantum ground state 8,9 and then amplify the remaining vacuum fluctuations into real energy quanta 10 . Exploiting a superconducting qubit as an artificial atom, we measure the photon/phonon-number distributions 11-13 during these optomechanical interactions. This provides an essential non-linear resource to, first, verify the ground state preparation and second, reveal the quantum vacuum fluctuations of the macroscopic oscillator's motion. Our results further demonstrate the ability to control a long-lived mechanical oscillator using a non-Gaussian resource, directly enabling applications in quantum information processing and enhanced detection of displacement and forces.Cavity optomechanical systems have emerged as an ideal testbed for exploring the quantum limits of linear measurement of macroscopic motion 2 , as well as a promising new architecture for performing quantum computations. In such systems, a light field reflecting off a mechanical oscillator acquires a position-dependent phase shift and reciprocally, it applies a force onto the mechanical oscillator. This effect is enhanced by embedding the oscillator inside a high-quality factor electromagnetic cavity. Numerous physical implementations exist, both in the microwave and optical domain, and have been used to push the manipulation of macroscopic oscillators into the quantum regime, demonstrating laser cooling to the ground state of motion 8,14 , coherent transfer of itinerant light fields into mechanical motion 9,15 , or their entanglement 10 . Thus far, linear position measurements have provided evidence for the quantization of light fields via radiation pressure shot noise 16,17 and mechanical vacuum fluctuations via motional sideband asymmetries 3-6 . However, the use of only classical and linear tools has restricted most optomechanical experiments to the manipulation of Gaussian states.The addition of a strong non-linearity, such as an atom, has fostered tremendous progress towards exquisite control over non-Gaussian quantum states of light fields and atomic motion 11,12 . First developed in the context of cavity quantum electrodynamics, these techniques are now widely applied to engineered systems, such as superconducting quantum bits (qubits) and microwave resonant circuits 13,18-21 . In a pioneering experiment incorporating a high-frequency mechanical osci...