Arbidol inhibits viral entry by interfering with clathrin-dependent trafficking

Blaising, Julie; Lévy, Pierre; Polyak, Stephen J.; Stanifer, Megan L.; Boulant, Steeve; Pécheur, Eve Isabelle

doi:10.1016/j.antiviral.2013.08.008

Cited by 77 publications

(82 citation statements)

References 21 publications

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“…Viruses from the Rhabdoviridae family are known to induce neurological disorders, encephalitis or, more recently reported, hemorrhagic fever (Grard et al, 2012). The only study addressing the effect of ARB against a virus of this family was conducted in our laboratory on the vesicular stomatitis virus (VSV) (Blaising et al, 2013). This enveloped RNA virus mainly infects cattle and pigs, causing oral lesions, anorexia and lethargy.…”

Section: Viruses Causing Hemorrhagic Fever and Encephalitismentioning

confidence: 99%

Arbidol as a broad-spectrum antiviral: An update

2014

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Arbidol (ARB) is a Russian-made small indole-derivative molecule, licensed in Russia and China for prophylaxis and treatment of influenza and other respiratory viral infections. It also demonstrates inhibitory activity against other viruses, enveloped or not, responsible for emerging or globally prevalent infectious diseases such as hepatitis B and C, gastroenteritis, hemorrhagic fevers or encephalitis. In this review, we will explore the possibility and pertinence of ARB as a broad-spectrum antiviral, after a careful examination of its physico-chemical properties, pharmacokinetics, toxicity, and molecular mechanisms of action. Recent studies suggest that ARB's dual interactions with membranes and aromatic amino acids in proteins may be central to its broad-spectrum antiviral activity. This could impact on the virus itself, and/or on cellular functions or critical steps in virus-cell interactions, thereby positioning ARB as both a direct-acting antiviral (DAA) and a host-targeting agent (HTA). In the context of recent studies in animals and humans, we will discuss the prospective clinical use of ARB in various viral infections.

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Section: Viruses Causing Hemorrhagic Fever and Encephalitismentioning

confidence: 99%

Arbidol as a broad-spectrum antiviral: An update

2014

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“…La libération de son matériel géné-tique a ensuite lieu après abaissement du pH dans les endosomes et fusion des membranes virale et endosomale [9] (Figure 2). Nous avons montré que l'arbidol ralentissait l'endocytose des virions VHC et inhibait la fixation de la petite GTPase Rab5 sur les endosomes impliqués dans le trafic des virions [10,11] (➜). Ceci a pour effet de différer le moment auquel prend place la fusion virale ; les virions, n'ayant pas pu libérer leur nucléocapside, seraient alors dirigés vers des compartiments de dégrada-tion de type lysosome [10].…”

Section: L'arbidol Inhibe Les éTapes Précoces De L'infection Par Le Vunclassified

“…Nous avons montré que l'arbidol ralentissait l'endocytose des virions VHC et inhibait la fixation de la petite GTPase Rab5 sur les endosomes impliqués dans le trafic des virions [10,11] (➜). Ceci a pour effet de différer le moment auquel prend place la fusion virale ; les virions, n'ayant pas pu libérer leur nucléocapside, seraient alors dirigés vers des compartiments de dégrada-tion de type lysosome [10]. L'arbidol inhibe également la scission membranaire induite par la dynamine-2, ce qui altère la formation des vésicules recouvertes de clathrine et donc l'endocytose dépendante de la clathrine.…”

Section: L'arbidol Inhibe Les éTapes Précoces De L'infection Par Le Vunclassified

La molécule antivirale arbidol inhibe des virus pathogènes de prévalence mondiale

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Polyak

2016

Med Sci (Paris)

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“…It was established that classical Clatrin and v-ATPhase inhibitors are effective viral reproduction inhibitors and belong to broad-spectrum class of medicines. It turned out that Arbidol also belongs to this group of inhibitors [25]. Thus, one more mechanism of Arbidol action was revealed, which could explain its wide spectrum antiviral activity.…”

Section: Mir-journalorgmentioning

confidence: 99%