Aralia continentalis kitagawa Extract Attenuates the Fatigue Induced by Exhaustive Exercise through Inhibition of Oxidative Stress

Abstract

The present study aimed to evaluate the anti-fatigue effects of Aralia continentalis kitagawa (AC) extract during exhaustive exercise of rats by forced swimming. Rats were subjected to forced swimming until exhausted after pre-treatment with AC extract for 21 days. Exhaustion time significantly increased in rats treated with AC extract. AC treatment also preserved blood homeostasis during fatigue due to exhaustive exercise. For fatigue-related serum biomarkers, AC extract significantly fail to decrease glucose and triglyceride (TG), but ameliorated increased lactate levels compared with levels in control rats. Metabolic acidosis, a major cause of fatigue, was effectively attenuated by AC extract, according to metabolic acidosis-related blood parameters. AC extract suppressed muscle injury and attenuated gastrocnemius muscle apoptotic responses due to exhaustive exercise. To investigate the mechanisms behind the AC extract anti-fatigue effect, we evaluated its effect on oxidative stress-related fatigue. We showed that pro-oxidants were inhibited, while antioxidants were preserved by AC extract treatment. Therefore, the anti-fatigue effect of AC extract was mediated by suppression of oxidative stress. Overall, the study demonstrated that AC extract effectively attenuates fatigue from exhaustive exercise through oxidative stress inhibition. AC extract, as an antioxidant, could be utilized as a therapeutic or preventive strategy against exhaustive exercise fatigue.

Next-Generation Ultrasol Curcumin Boosts Muscle Endurance and Reduces Muscle Damage in Treadmill-Exhausted Rats

“…The beneficial effects of regular physical activity on improving insulin sensitivity, limiting metabolic syndrome, reducing blood pressure, and improving muscle metabolic activity and antioxidant function have been previously established [ 1 , 2 , 3 , 4 ]. However, exercise-induced fatigue and muscle-soreness, if ignored, may negatively affect health and wellbeing.…”

A Dose-Dependent Effect of Carnipure® Tartrate Supplementation on Endurance Capacity, Recovery, and Body Composition in an Exercise Rat Model

“…The importance of physical training in promoting various health benefits, such as increased insulin sensitivity, diminished risk factors for metabolic syndrome, reduced blood pressure (preventing hypertension), and improved muscle metabolism and antioxidant capacity have been demonstrated [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 ]. Physical exercise promotes muscle mass and muscle functions by increasing muscle protein synthesis and stimulating mitochondrial biogenesis [ 9 , 10 ].…”

A Comparative Study on Relieving Exercise-Induced Fatigue by Inhalation of Different Citrus Essential Oils

“…Effective ATP resynthesis is needed to match the dramatically increased ATP consumption in response to strenuous exercise [ 29 ]. Liver glycogen, muscle glycogen, and blood glucose are related to energy supply during exercise [ 5 , 30 ]. High-intensity strenuous exercise can activate the sympathetic nervous system of the body.…”

“…To date, various natural agents and/or substances have been utilized in preventing exercise fatigue since they are natural, environmentally friendly, and have low adverse effects on the body when compared with other ingredients. In particular, it has been demonstrated that some phytogenic active ingredients, especially polysaccharides [ 4 ], polyphenols [ 5 ], and polypeptides [ 6 ], exhibit excellent fatigue-relieving activities. Although significant efforts have been made to develop natural active ingredients with fatigue-relieving functions, it would be still beneficial to develop novel efficient compounds to overcome the fatigue induced by exercise.…”