Arachidonic acid metabolism in renal disease

Lear, S.; Kelley, Vicki Rubin

doi:10.1007/978-94-009-1285-4_3

Eicosanoids in the Cardiovascular and Renal Systems 1988

DOI: 10.1007/978-94-009-1285-4_3

|View full text |Cite

Arachidonic acid metabolism in renal disease

S. Lear¹,

Vicki Rubin Kelley²

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1991

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 207 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

'Low sodium' diuresis and ileal loss in patients with ileostomies: effect of desmopressin.

Sutters

Carmichael²,

Unwin³

et al. 1991

Gut

View full text Add to dashboard Cite

Patients with ileostomies show an early diuresis when sodium restricted; this, together with an obligatory ileal sodium loss, predisposes them to severe salt and water depletion. The role of arginine vasopressin in this circumstance and whether it is natriuretic, or antinatriuretic, is unclear. There is also controversy over its likely effect on smali bowel fluid reabsorption. We have examined the effect of the non-pressor (V,) synthetic vasopressin analogue 1-deamino-8-D-arginine (desmopressin) on renal and ileal sodium and water excretion in ileostomy patients during acute adaptation to a low sodium diet. Patients were studied on two separate occasions (nonrandomised) with and without the administration of desmopressin (0.75 [ig intramuscular, three times a day). In eight subjects without desmopressin there was pronounced diuresis on the first low sodium day, associated with a fall in renal sodium excretion and no change in ileal output or composition. In five (of the original) subjects with desmopressin there was pronounced antidiuresis, no change in renal sodium excretion, and no change in ileal output or composition. In both studies rises in plasma renin activity and salivary aldosterone concentration lagged behind the early decline in renal sodium excretion. We have confirmed the phenomenon of 'low sodium' diuresis after sodium restriction in ileostomy patients and shown that it can be prevented by desmopressin. Desmopressin has no direct or indirect effect on renal sodium excretion or ileal fluid and electrolyte loss in humans.

show abstract

'Low sodium' diuresis and ileal loss in patients with ileostomies: effect of desmopressin.

Sutters

Carmichael²,

Unwin³

et al. 1991

Gut

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Arachidonic acid metabolism in renal disease

Cited by 1 publication

References 207 publications

'Low sodium' diuresis and ileal loss in patients with ileostomies: effect of desmopressin.

'Low sodium' diuresis and ileal loss in patients with ileostomies: effect of desmopressin.

Contact Info

Product

Resources

About