1990
DOI: 10.1111/j.1471-4159.1990.tb02318.x
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Arachidonic Acid Incorporation and Redistribution in Human Neuroblastoma (SK‐N‐BE) Cell Phospholipids

Abstract: The incorporation and redistribution of [1-14C]arachidonic acid in SK-N-BE human neuroblastoma cell phospholipids were investigated. By continuous labelling in serum-enriched medium, a rapid radioactivity incorporation into phosphatidylcholine (PtdCho), phosphatidylinositol, and phosphatidylserine was observed; initially, phosphatidylethanolamine (PtdEtn) was poorly labelled, but at later stages it displayed the highest level of arachidonic acid incorporation, in comparison with other phospholipid classes. Lab… Show more

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Cited by 26 publications
(2 citation statements)
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“…The fatty acid is indeed most strongly decreased in ChoPG, a finding also reported in other tis sues [37], This is consistent with recent data suggesting initial acylation of the 2-lyso-ChoPG molecule by polyun saturated fatty acids. Subsequent transfers of these fatty acids to other phosphoglyceride classes are assumed to result from selective deacylation/reacylation processes [38][39][40][41] On the other hand, preferential conservation of AA InsPG content in AA in spite of the metabolically active nature of InsPG could be related to the importance of AA containing InsPG for transduction processes. It also sug gests preferential PLC-generated DAG rephosphorylation by the DAG kinase and low DAG lipase activity in pitu itary membranes.…”
Section: Discussionmentioning
confidence: 99%
“…The fatty acid is indeed most strongly decreased in ChoPG, a finding also reported in other tis sues [37], This is consistent with recent data suggesting initial acylation of the 2-lyso-ChoPG molecule by polyun saturated fatty acids. Subsequent transfers of these fatty acids to other phosphoglyceride classes are assumed to result from selective deacylation/reacylation processes [38][39][40][41] On the other hand, preferential conservation of AA InsPG content in AA in spite of the metabolically active nature of InsPG could be related to the importance of AA containing InsPG for transduction processes. It also sug gests preferential PLC-generated DAG rephosphorylation by the DAG kinase and low DAG lipase activity in pitu itary membranes.…”
Section: Discussionmentioning
confidence: 99%
“…Two-dimensional separation of phospholipids was carried out on high-performance t.l.c. plates as described [16]. Neutral lipids and free fatty acids were separated on high-performance t.l.c.…”
Section: Cell Culturementioning
confidence: 99%