Arachidonic Acid, but Not Omega‐3 Index, Relates to the Prevalence and Progression of Abdominal Aortic Aneurysm in a Population‐Based Study of Danish Men

Lindholt, Jes Sanddal; Kristensen, Katrine Lawaetz; Burillo, Elena; Martínez-López, Diego; Calvo, Carlos; Ros, Emilio; Martı́n-Ventura, José Luis; Sala‐Vila, Aleix

doi:10.1161/jaha.117.007790

Cited by 17 publications

(12 citation statements)

References 23 publications

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“…Numerous biological factors have been identified that contribute to AAA occurrence, e.g., serum elastin peptides (SEP), plasmin-antiplasmin (PAP) complexes, metalloproteinase-2 (MMP-2), metalloproteinase-9 (MMP-9), P-elastase, cystein C, tissue plasminogen activator (tPA), interferon-gamma (IFN-gamma), tumor necrosis factor alpha (TNF-alpha), interleukin-8 (Il-8), interleukin-6 (Il-6), macrophage migration inhibitory factor (MIF), osteopontin, osteoprogerin, fibrynogen, homocysteine, Staphylococcus sp., Chlamydophila pneumoniae, Treponema pallidum, and arachidonic acid [3]. Moreover, in some cases, biomarkers such as arachidonic acid [4] and MMP-9 [5] have also been evaluated as indicators of possible success of the AAA therapy.…”

Section: Introductionmentioning

confidence: 99%

Calprotectin and Receptor for Advanced Glycation End Products as a Potential Biomarker in Abdominal Aortic Aneurysm

Hauzer¹,

Witkiewicz

Gnus

2020

JCM

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Experiments conducted in recent years on animals and research works worldwide show a linkage between calprotectin and occurrence and development of the abdominal aortic aneurysm (AAA). Additionally, a correlation between the level of the receptor for advanced glycation end products (RAGE) and the diameter of the abdominal aorta was found. The purpose of this study was to investigate whether calprotectin and the RAGE plasma level may be a biomarker of human AAA occurrence. We determined two groups of research participants: a group of 32 patients aged 53–88 undergoing primary endovascular aneurysm repair and a control group of 43 volunteers aged 59–82 without the AAA. All the patients from the study group had their blood samples drawn in order to determine the level of calprotectin and RAGE in plasma. The second follow-up examination was carried out after three months. The concentration of calprotectin and RAGE in plasma was determined with the use of the immunoenzymatic method (ELISA). The study showed that patients with the AAA had significantly higher mean calprotectin and RAGE plasma levels (p = 0.0001 and p = 0.0002, respectively) as compared to the control group. After the AAA repair operations, the level of concentration of the calprotectin decreased significantly (p = 0.0002). So far, no studies on the connection between the increase of the calprotectin and RAGE in the patient’s plasma with the AAA have been published. Calprotectin may be a promising biomarker related to the occurrence of AAA. Larger studies are needed to fully elucidate and confirm the role of calprotectin in the development and progression of the aneurysm.

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Section: Introductionmentioning

confidence: 99%

Calprotectin and Receptor for Advanced Glycation End Products as a Potential Biomarker in Abdominal Aortic Aneurysm

Hauzer¹,

Witkiewicz

Gnus

2020

JCM

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“…It would be interesting to test the variation of MCE in two sequential samples of the same small/medium AAA patients at two time points of their follow-up (at least on those who progress and would not require surgery) to evaluate whether the changes in MCE are correlated to changes in aortic diameter. In addition, it is important to note that to obtain correlation with AAA growth or time to surgery, we previously tested the whole VIVA cohort [27,28], so in this case, lack of power could also account for the obtained negative results. However, considering alpha = 0.05 and power = 80%, it was estimated that a difference of 2% in MCE could be detected by studying a minimum of 20 subjects in each group.…”

Section: Discussionmentioning

confidence: 99%

Macrophage Cholesterol Efflux Downregulation Is Not Associated with Abdominal Aortic Aneurysm (AAA) Progression

et al. 2020

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Recent studies have raised the possibility of a role for lipoproteins, including high-density lipoprotein cholesterol (HDLc), in abdominal aortic aneurysm (AAA). The study was conducted in plasmas from 39 large size AAA patients (aortic diameter > 50 mm), 81 small/medium size AAA patients (aortic diameter between 30 and 50 mm) and 38 control subjects (aortic diameter < 30 mm). We evaluated the potential of HDL-mediated macrophage cholesterol efflux (MCE) to predict AAA growth and/or the need for surgery. MCE was impaired in the large aortic diameter AAA group as compared with that in the small/medium size AAA group and the control group. However, no significant difference in HDL-mediated MCE capacity was observed in 3 different progression subgroups (classified according to growth rate < 1 mm per year, between 1 and 5 mm per year or >5 mm per year) in patients with small/medium size AAA. Moreover, no correlation was found between MCE capacity and the aneurysm growth rate. A multivariate Cox regression analysis revealed a significant association between lower MCE capacity with the need for surgery in all AAA patients. Nevertheless, the significance was lost when only small/medium size AAA patients were included. Our results suggest that MCE, a major HDL functional activity, is not involved in AAA progression.

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“…The statistical tests were defined a priori and in a similar way as in previous publications. 19,26,27 Nonparametric statistics were used for descriptive and univariate analyses. The assumption of normality of continuous measurements was confirmed by visual inspection of residual log-log plots.…”

Section: Methodsmentioning

confidence: 99%

“…As previously described, predefined logistic regression analysis was used to identify whether the upper tertile pMFAP4 at baseline was independently associated with AAA after adjustment for potential confounders identified in the univariate analyses by a P value below 0.10. 27 Multiple linear regression analysis was used to identify whether the level of pMFAP4 at baseline was independently associated with aneurysmal growth rate after similar adjustment for potential confounders. We constructed a Cox proportional hazard model to study whether AAA patients at the upper tertile at baseline had an altered likelihood of receiving later surgical repair.…”

Section: Methodsmentioning

confidence: 99%

High plasma microfibrillar-associated protein 4 is associated with reduced surgical repair in abdominal aortic aneurysms

Lindholt

Madsen

Kirketerp-Møller

et al. 2020

Journal of Vascular Surgery

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Objective: Identifying biomarkers for abdominal aortic aneurysms (AAA) could prove beneficial in prognosis of AAA and thus the selection for treatment. Microfibrillar-associated protein 4 (MFAP4) is an extracellular matrix protein that is highly expressed in aorta. MFAP4 is involved in several tissue remodeling-related diseases. We aimed to investigate the potential role of plasma MFAP4 (pMFAP4) as a biomarker of AAA. Methods: Plasma samples and data were obtained for 504 male AAA patients and 188 controls in the Viborg Vascular (VIVA) screening trial. The pMFAP4 levels were measured by Alphalisa. The Mann-Whitney U test assessed differences in pMFAP4 levels between the presence and absence of different exposures of interest. The correlation between pMFAP4 and aorta growth rate were investigated through spearman's correlation analysis. Immunohistochemistry and multiple logistic regression adjusted for potential confounders assessed the association between pMFAP4 and AAA. Multiple linear regression assessed the correlation between pMFAP4 and aorta growth rate. Cox regression and competing risk regression were used to investigate the correlation between AAA patients with upper tertile pMFAP4 and the risk of undergoing later surgical repair. Results: A significant negative correlation between pMFAP4 and aorta growth rate was observed using spearman's correlation analysis (r ¼ À0.14; P ¼ .0074). However, this finding did not reach significance when applying multiple linear regression. A tendency of decreased pMFAP4 was observed in AAA using immunohistochemistry. Competing risk regression adjusted for potential confounders indicated that patients with upper tertile pMFAP4 had a hazard ratio of 0.51 (P ¼ .001) for risk of undergoing later surgical repair. Conclusions: High levels of pMFAP4 are associated with a decreased likelihood of receiving surgical repair in AAA. This observation warrants confirmation in an independent cohort.

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Arachidonic Acid, but Not Omega‐3 Index, Relates to the Prevalence and Progression of Abdominal Aortic Aneurysm in a Population‐Based Study of Danish Men

Cited by 17 publications

References 23 publications

Calprotectin and Receptor for Advanced Glycation End Products as a Potential Biomarker in Abdominal Aortic Aneurysm

Calprotectin and Receptor for Advanced Glycation End Products as a Potential Biomarker in Abdominal Aortic Aneurysm

Macrophage Cholesterol Efflux Downregulation Is Not Associated with Abdominal Aortic Aneurysm (AAA) Progression

High plasma microfibrillar-associated protein 4 is associated with reduced surgical repair in abdominal aortic aneurysms

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