Arabinogalactans from Mimosa tenuiflora (Willd.) Poiret bark as active principles for wound-healing properties: Specific enhancement of dermal fibroblast activity and minor influence on HaCaT keratinocytes

Zippel, Janina; Deters, Alexandra; Hensel, Andreas

doi:10.1016/j.jep.2009.05.034

Cited by 40 publications

(23 citation statements)

References 20 publications

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“…Some researchers reported that M. tenuiflora induced specific enhancement of dermal fibroblast activity in vitro [17]. It should be considered that this experimental study is not reproducible in animal or human models.…”

Section: Resultsmentioning

confidence: 97%

Skin Wound Healing and Phytomedicine: A Review

Pazyar

Yaghoobi²,

Rafiee³

et al. 2014

Skin Pharmacol Physiol

198

137

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Skin integrity is restored by a physiological process aimed at repairing the damaged tissues. The healing process proceeds in four phases: hemostasis, inflammation, proliferation and remodeling. Phytomedicine presents remedies, which possess significant pharmacological effects. It is popular amongst the general population in regions all over the world. Phytotherapeutic agents have been largely used for cutaneous wound healing. These include Aloe vera, mimosa, grape vine, Echinacea, chamomile, ginseng, green tea, jojoba, tea tree oil, rosemary, lemon, soybean, comfrey, papaya, oat, garlic, ginkgo, olive oil and ocimum. Phytotherapy may open new avenues for therapeutic intervention on cutaneous wounds. This article provides a review of the common beneficial medicinal plants in the management of skin wounds with an attempt to explain their mechanisms.

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Section: Resultsmentioning

confidence: 97%

Skin Wound Healing and Phytomedicine: A Review

Pazyar

Yaghoobi²,

Rafiee³

et al. 2014

Skin Pharmacol Physiol

198

137

View full text Add to dashboard Cite

show abstract

“…In a recent trial by Zippel et al (16), the authors found that the polyphenols present in the cortex of M. tenuiflora are toxic to fibroblasts in vitro but did not show any apparent toxicity to keratinocytes. They also report very good antimicrobial efficacy.…”

Section: Discussionmentioning

confidence: 99%

“…Sibbald et al (1) suggested in a trial, where the inflammatory infiltrate was evaluated, that a failure of the ulcers to heal correlated with a persistant neutrophilic infiltrate, while the presence of a lymphocitic infiltrate showed faster healing. The effect on the inflammatory infiltrate may very well be explained by the antiinflammatory properties of the tepescohuite bark (7,11,16). Unfortunately, the relevance of this finding did not correlate with the clinical outcomes either.…”

Section: Key Pointsmentioning

confidence: 99%

A randomised comparative trial on the use of a hydrogel with tepescohuite extract (Mimosa tenuiflora cortex extract‐2G) in the treatment of venous leg ulcers

Lammoglia-Ordiales

Vega‐Memije

Herrera-Arellano

et al. 2011

International Wound Journal

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Tepescohuite is an extract obtained from the bark of the Mimosa tenuiflora tree and is used as an empirical treatment in wounds for its healing and antiseptic properties. Venous leg ulcers (VLUs) are a common health care problem in most countries with a high rate of morbidity. The standard of care is moist interactive healing and compression; however, the ideal topical treatment is yet to be established. This study is designed to evaluate the effectiveness and safety of M. tenuiflora cortex extract (MTC-2G) in the treatment of VLUs in an Interdisciplinary Wound and Ostomy Care Center (IWOCC). A randomised, placebo-controlled, double blind clinical trial was conducted to compare the use of a hydrogel containing MTC-2G with the hydrogel alone in VLUs. The study included all patients with venous ulcers referred to the IWOCC. Laboratory tests and tissue biopsies were performed at the beginning and at the end of the study. The patients were instructed to daily cleansing followed by topical application of the hydrogel and compression. Forty-one patients were included, 22 patients received the MTC-2G and 19 patients received the hydrogel only. Of the 41 patients, 32 completed the study, 18 in the experimental arm and 14 in the control group, 19 were women and 13 men. The mean age of the subjects was 60 years. The mean time from presentation was 38 months. The mean surface reduction was 6·29 cm(2) [confidence interval (IC) 95%: 3·28-9·29] (P = 0·0001) in the MTC-2G group and 5·85 cm(2) (95% CI: 3·58-8·12) (P = 0·001) in the hydrogel group. There was no significant difference between the groups (P = 0·815). No changes in the laboratory parameters were noted. In the histology, there were not any differences between groups either. A hydrogel containing MTC-2G was not superior to a hydrogel alone in the treatment of VLUs.

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“…Pharmacological studies showed that M . tenuiflora extracts show antimicrobial, antiplasmolytic, anti-inflammatory, hemolytic and wound healing activities [47,49]. It contains diverse classes of secondary metabolites -indole alkaloids, tannins, chalcones, steroids, saponins and flavonoids [48].…”

Section: Illegal Plant Species Descriptionmentioning

confidence: 99%

Psychoactive plants used in designer drugs as a threat to public health

2015

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S u m m a r yBased on epidemiologic surveys conducted in [2007][2008][2009][2010][2011][2012][2013], an increase in the consumption of psychoactive substances has been observed. This growth is noticeable in Europe and in Poland. With the 'designer drugs' launch on the market, which ingredients were not placed on the list of controlled substances in the Misuse of Drugs Act, a rise in the number and diversity of psychoactive agents and mixtures was noticed, used to achieve a different state of mind. Thus, the threat to the health and lives of people who use them has grown. In this paper, the authors describe the phenomenon of the use of plant psychoactive substances, paying attention to young people who experiment with new narcotics. This article also discusses the mode of action and side effects of plant materials proscribed under the

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Arabinogalactans from Mimosa tenuiflora (Willd.) Poiret bark as active principles for wound-healing properties: Specific enhancement of dermal fibroblast activity and minor influence on HaCaT keratinocytes

Cited by 40 publications

References 20 publications

Skin Wound Healing and Phytomedicine: A Review

Skin Wound Healing and Phytomedicine: A Review

A randomised comparative trial on the use of a hydrogel with tepescohuite extract (Mimosa tenuiflora cortex extract‐2G) in the treatment of venous leg ulcers

Psychoactive plants used in designer drugs as a threat to public health

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