Arabinogalactan protein from Arachis hypogaea: Role as carrier in drug-formulations

Parveen, Seema; Gupta, Ashish Deep; Prasad, Ramasare

doi:10.1016/j.ijpharm.2006.10.003

Cited by 10 publications

(5 citation statements)

References 43 publications

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“…The residual REEs (such as gadolinium) in human body results in nephrogenic systemic fibrosis (37). AGPs in human are obtained through diet, mostly plant-based diet (38,39), bind or adhere to the cell surface (40,41), and perform important functions such as reducing the cholesterol in the blood (42), regulating immunity (43), and serving as targeted-drug carriers to deliver drug to target organs rapidly (39). Therefore, we asked whether La(III) induced the activation of AGP-dependent endocytosis in human cells.…”

Section: Agp-dependent Endocytosis In the Presence Of La(iii) Also Ocmentioning

confidence: 99%

“…S6B). In mammalian cells, except for AGPs, no glycoproteins have been reported that can be inhibited by β-glucosyl Yariv (39,42,43), while fetal bovine serum containing AGPs (44,45) was added in the culture medium (46). So, it seems likely that AGPs also activate and regulate REEs' endocytosis in human cells.…”

Section: Agp-dependent Endocytosis In the Presence Of La(iii) Also Ocmentioning

confidence: 99%

See 1 more Smart Citation

Arabinogalactan protein–rare earth element complexes activate plant endocytosis

Wang

Cheng

Yang

et al. 2019

Proc. Natl. Acad. Sci. U.S.A.

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Endocytosis is essential to all eukaryotes, but how cargoes are selected for internalization remains poorly characterized. Extracellular cargoes are thought to be selected by transmembrane receptors that bind intracellular adaptors proteins to initiate endocytosis. Here, we report a mechanism for clathrin-mediated endocytosis (CME) of extracellular lanthanum [La(III)] cargoes, which requires extracellular arabinogalactan proteins (AGPs) that are anchored on the outer face of the plasma membrane. AGPs were colocalized with La(III) on the cell surface and in La(III)-induced endocytic vesicles inArabidopsisleaf cells. Superresolution imaging showed that La(III) triggered AGP movement across the plasma membrane. AGPs were then colocalized and physically associated with the μ subunit of the intracellular adaptor protein 2 (AP2) complexes. The AGP-AP2 interaction was independent of CME, whereas AGP’s internalization required CME and AP2. Moreover, we show that AGP-dependent endocytosis in the presence of La(III) also occurred in human cells. These findings indicate that extracellular AGPs act as conserved CME cargo receptors, thus challenging the current paradigm about endocytosis of extracellular cargoes.

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Section: Agp-dependent Endocytosis In the Presence Of La(iii) Also Ocmentioning

confidence: 99%

Section: Agp-dependent Endocytosis In the Presence Of La(iii) Also Ocmentioning

confidence: 99%

Arabinogalactan protein–rare earth element complexes activate plant endocytosis

Wang

Cheng

Yang

et al. 2019

Proc. Natl. Acad. Sci. U.S.A.

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“…Authors suggested that the higher degree of antiviral activity of SSFK-10RM could be linked to the high purity of the polysaccharide and its reduced cytotoxicity is caused by its shorter highly charged HG region. In addition to this, because of their high solubility and biocompatibility, AGPs have been proposed as potent carrier in amphotericin B (AmB) formulation (Parveen et al 2007).…”

Section: Agps and Biotic Stressesmentioning

confidence: 99%

Arabinogalactan proteins: actors or spectators during abiotic and biotic stress in plants?

Mareri

Romi

Cai

2018

Plant Biosystems - An International Journal Dealing with all As

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Arabinogalactan proteins (AGPs) are a family of hydroxyproline-rich glycoproteins (HRGP) ubiquitous in the plant kingdom. They are probably one of the most heterogeneous and complex families of macromolecules, making them able to perform different and multiple functions. Located at the plasma membrane-cell wall interface, AGPs are involved in several processes, from plant growth and development to reproduction. An additional function of AGPs in response to biotic and abiotic stress has been suggested by several studies. The purpose of this review is to summarize critically and analytically the available knowledge on the effects of abiotic stress (low and high temperatures, drought, flooding, anoxia and metal deficiency/toxicity) and biotic stress (bacteria, fungi, nematodes and viruses) on AGPs. A deeper understanding of the role of AGPs during these conditions can be an important tool for understanding AGP biology and for the possible development of efficient breeding strategies.

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“…It is also an appropriate polymer for coating nanocomposites of LDH-enalapril (Ribeiro, Arizaga, Wypych, & Sierakowski, 2008). Arabinogalactans also demonstrated that could be used as carrier in drug-formulations (Parveen, Gupta, & Prasad, 2007).…”

Section: Introductionmentioning

confidence: 99%