Arabica coffee and olive oils mitigate malathion-induced nephrotoxicity in rat: In silico, immunohistochemical and biochemical evaluation

Potential therapeutic benefits of unconventional oils: assessment of the potential in vitro biological properties of some Rubiaceae, Cucurbitaceae, and Brassicaceae seed oils

“…Coffee oil exhibited different beneficial effects, such as anti-cancerous, anti-inflammatory, anti-bacterial, antiviral, anti-diabetic, and anti-atherosclerotic (15) and also exerts protective effects against nephrotoxicity in animal models (16). Broccoli seed oil demonstrated inhibitory activity against the growth of different gram-positive and Ggam-negative bacteria (17), and, like other Brassicaceae, it can exhibit multiple health functions (18) indeed. Broccoli seed oil was recently used to develop innovative green materials due to its high content of long-chain fatty acids, such as erucic acid.…”

Effect of vinpocetine against acrylamide‐induced nephrotoxicity in rats

“…The ACR‐treated rats in this study showed lower levels of serum protein (TP, Alb, and Glo) which may be due to ACR‐induced kidney injury causing protein leakage from the kidneys associated with decreased serum proteins. Supporting this suggestion, Al‐Asmari et al [ 25 ] reported that albumin deficiency in the blood indicates a kidney or liver dysfunction. In addition, Idris et al [ 26 ] demonstrated that the administration of ACR increased proteinuria and reduced serum protein in mother rats as a result of kidney damage.…”

Exploring the Role of Phenolic Compounds in Chronic Kidney Disease: A Systematic Review

“…Further research has shown that polyphenol-rich foods, including Indian plums [ 124 ], radishes [ 125 , 126 ], green algae [ 127 ], acacia gum [ 128 ], basil leaves [ 129 , 130 ], essential oils [ 131 ], coffee and olive oils [ 132 ], and red palm oil [ 133 , 134 ], can ameliorate kidney damage induced by various toxins. Moreover, phenolic compounds have shown promising results in preventing further heavy-metal-induced kidney injury [ 135 , 136 , 137 ].…”

“…Myricetin [118] ↓ BUN, β2-MG, and Cys C ↑ GR activity, TAS and GPx, MDA ↓ TNF-α and IL-1β [118] Tannins, phenolics, flavonoids, steroid glycosides, terpenoids, and saponins [119] ↓ serum concentrations of BUN and creatinine ↓ renal tubular and glomerular alterations [119] Gallic acid, (+)-catechin, (-)-epicatechin, and ellagic acid [120] ↓ ALT and AST activities ↓ MDA, APOP and NO in plasma, heart, and kidney ↓ uric acid level, and plasma creatinine level [120] Chlorogenic acid, diosmin, and caffeic acid [122] ↓ urinary NGAL, endothelin-1, and clusterin levels ↓ BUN, creatinine, 8-OHda, isoprostane, adiponectin, and cystatin ↓ serum XOD, liver XOD, serum ADA, liver ADA, and serum UA levels [121] 6-Shogaol, 6-Paradol, and 6-Gingerol [123] ↓ plasma and blood creatinine and urea ↓ GSH level ↑ SOD level [123] Ferulic acid, caffeic acid and vanillic acid [124] ↓ MDA, APOP, uric acid and creatinine levels in the blood, IL-1, IL-6, TNF-α, TGF-β1, and NF-κB ↑ catalase and SOD activities in the kidneys [124] Chlorogenic, vanillic, caffeic, syringic, p-coumaric, and ferulic acids [126] ↓ serum urea, uric acid and creatinine levels ↑ kidney SOD, CAT, GPx, GST, and GR activities [125] Lutein and chlorophyll [127] ↑ CAT and SOD ↓ urea, creatinine, uric acid, GGT, CK, BUN, and β2-microglobulin ↓ levels of TNFα, IL-6, IL-β, and TGF-α [127] Benzoic acids [128] ↓ levels of Nrf2 and SOD1 in renal tissue Normal architecture of renal tissue (renal corpuscle, proximal and distal convoluted tubules, and collecting ducts) [128] Rosmarinic acid [130] ↓ serum creatinine, BUN, and uric acid [129] Eugenol [131] ↓ oxidative stress, inflammation, and apoptosis ↓ proinflammatory markers (IL6 and TNF-α) [131] Chlorogenic acid, hydroxytyrosol, and tyrosol [132] ↓ creatinine, uric acids, and BUN [132] Pyrogallol, 4-hydroxybenzoic acid, gallic acid, and ferulic acid [134] ↑ GSH, SOD, CAT ↓ MDA [133] Secoisolariciresinol diglucoside [135] ↓ levels of NO and MPO ↑ superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase…”