AR coactivators, CBP/p300, are critical mediators of DNA repair in prostate cancer
Sumaira Sardar,
Christopher M. McNair,
Lakshmi Ravindranath
et al.
Abstract:Castration resistant prostate cancer (CRPC) remains an incurable disease stage with ineffective treatments options. Here, the androgen receptor (AR) coactivators CBP/p300, which are histone acetyltransferases, were identified as critical mediators of DNA damage repair (DDR) to potentially enhance therapeutic targeting of CRPC. Key findings demonstrate that CBP/p300 expression increases with disease progression and selects for poor prognosis in metastatic disease. CBP/p300 bromodomain inhibition enhances respon… Show more
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