Aquilide A, a new mutagenic compound isolated from bracken fern (Pteridium aquilibrium) (L.) Kuhn

Hoeven, J.C.M. van der; Lagerweij, W.J.; Jongen, W.M.F.; Posthumus, M.A.; Veldhuizen, A. van; Holterman, H.A.J.

doi:10.1016/0165-1161(84)90267-x

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“…Ptaq was later isolated and identified as the principal bracken carcinogen and the cause of the retinal degeneration [29], clastogenicity [35], and mutagenicity [38,39,51]. It was hypothesized that ptaq was transferred through milk to calves and possibly humans from bracken-fed lactating cows [53,54].…”

Section: Introductionmentioning

confidence: 99%

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Excretion, through milk, of ptaquiloside in bracken-fed cows. A quantitative assessment

Alonso‐Amelot

Castillo

Smith³

et al. 1998

Lait

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-The content of ptaquiloside (ptaq), a major Pteridium aquilinum carcinogen found in milk from cows fed bracken in Venezuela, has been estimated quantitatively in ils passage through bovines into milk. Six cows were given 6 kg/animal/d of fresh bracken fronds whose ptaq content was determined. Ptaq first appeared in milk 38 h after initially feeding this plant to the cows and continued to be excreted at a relatively constant level, after an induction period, for 62-70 h after the bracken diet had ceased. The average value of total ptaq excreted ([ptaq]e) from milk amounted to 8.60 ± 1.16 % of the total ptaq ingested ([ptaq]) during the entire feeding period.[ptaq]e was linearly dose dependent in the 2 400 to 10 000 mg/animal/d range of ptaq given to the test animais and the ratio [ptaqle/jptaq], remained relatively constant at various ptaq dosages. In a two-pulse feeding sequence with a 72-h interlude when no bracken was given, a bimodal ptaq excretion curve was obtained. The implications to human health are discussed. © InralElsevier, Paris ptaquiloside / bracken fern / cow's milk Résumé -Excrétion du ptaquiloside dans le lait de vaches alimentées avec de la fougère Bracken, Évaluation quantitative. La quantité de ptaquiloside (ptaq), le principal carcinogène de Pteridium aquilinum, retrouvé dans le lait de vaches alimentées avec la fougère bracken au Venezuela, a été estimée quantitativement. On a donné à six vaches 6 kglj de frondes fraîches de fougère, dont le contenu en ptaq a été deterrniné. Le ptaq est apparu d'abord dans le lait 38 heures après la première prise et a continué à être excrété à une concentration plus ou moins constante après une période d'induction, jusqu'à 62-70 heures après que l'alimentation en fougère a cessé. Ensuite, le ptaq a graduellement diminué jusqu'à ce qu'il ait disparu du lait. La valeur moyenne de ptaq excrétée dans le * Correspondence and reprints.

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Section: Introductionmentioning

confidence: 99%

“…Ptaquiloside (ptaq), a norsesquiterpene glucoside ofbracken fem (genus Pteridium) and sorne other related fems, with an illudane skeleton [40,51] is one of the most potent known carcinogens of natural origin [26]. It has been shown in vitro to bind covalently to nucleotides hence splitting the uncoiled DNA chain [33,41].…”

Section: Introductionmentioning

confidence: 99%