Utah is one of the top producers of oil and natural gas in the United States. Over the past 18 years, more than 4.2 billion gallons of wastewater from the petroleum industry has been injected into the Navajo Sandstone, Kayenta Formation, and Wingate Sandstone in Carbon and Emery Counties, central Utah, where seismicity has increased during the same period. Previous studies have attributed this seismicity to coal mining. Here, we present evidence for wastewater injection being a major cause of the increased seismicity. We show that, in the coal mining area, seismicity rate increased significantly 1–5 years following the wastewater injection, and the earthquakes, mostly with magnitudes <3.0, are concentrated in areas seismically active prior to the injection. Using simple analytical and numerical models, we show that the injection in central Utah can sufficiently raise pore pressure to trigger seismicity within 10–20 km of the injection wells, and the time needed for the diffusion of pore pressure may explain the observed lag of seismicity increase behind the commencement of injection. The b‐value of these earthquakes increased following the wastewater injection, which is consistent with these events being injection‐induced. We conclude that the marked increase in seismicity rate in central Utah is induced by both mining activity and wastewater injection, which raised pore pressure along preexisting faults.