Aqueous solubility of permethylsiloxanes (silicones)

Varaprath, Sudarsanan; Frye, Cecil L.; Hamelink, Jerry L.

doi:10.1002/etc.5620150803

Cited by 105 publications

(63 citation statements)

References 7 publications

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“…As stated in the Introduction , limited data are available regarding the experimentally determined H c values for siloxanes. However, data regarding saturation aqueous solubility and pure component vapor pressure for most siloxanes are available in the literature [5,6]. Varaprath et al [5] obtained the solubility values of several permethylsiloxanes (i.e., silicones) using a carefully designed experimental setup that avoided the formation of colloidal dispersions in water.…”

Section: Resultsmentioning

confidence: 99%

“…However, data regarding saturation aqueous solubility and pure component vapor pressure for most siloxanes are available in the literature [5,6]. Varaprath et al [5] obtained the solubility values of several permethylsiloxanes (i.e., silicones) using a carefully designed experimental setup that avoided the formation of colloidal dispersions in water. Flaningam [6] reported the experimental data and correlation of vapor pressure data for several oligomers.…”

Section: Resultsmentioning

confidence: 99%

“…Silicones have low aqueous solubility and are highly hydrophobic. Because of their tendency to form colloidal dispersions, the aqueous solubility measurement is problematic [5]. Data regarding vapor pressures exist over wide temperature ranges [6].…”

Section: Introductionmentioning

confidence: 99%

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Air‐water partition constants for volatile methyl siloxanes

Кочетков

Smith

Ravikrishna

et al. 2001

Enviro Toxic and Chemistry

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Silicones are an important class of hydrophobic compounds in widespread use. To evaluate their fate in the environment, an accurate value of the air-water partition (Henry's law) constant is necessary, which, unfortunately, is lacking at present. A static head space and a newly developed dynamic vapor entry loop method were used to obtain the air-water partition constant for six volatile methyl siloxanes. Internally consistent data were obtained. The value of Henry's constant, as calculated from pure component vapor pressure and aqueous solubility, was 10- to 170-fold greater than the experimental values. A correction to the Henry's constant that involves the ratio of the thermodynamic activity coefficient for a methyl siloxane at infinite dilution to that at saturation solubility in the aqueous phase is proposed.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Air‐water partition constants for volatile methyl siloxanes

Кочетков

Smith

Ravikrishna

et al. 2001

Enviro Toxic and Chemistry

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“…[10] The molecular weight of HMDS is 162.38 with a density of 0.764 g/ml at 20°C. It can be produced by the hydrolysis of trimethylsilyl chloride.…”

Section: Introductionmentioning

confidence: 99%

Influence of silane‐modified Vinyl ester on the properties of Abaca fiber reinforced composites

et al. 2017

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The versatility of the fiber reinforced composites has significantly replaced some of the sophisticated metal components in certain sectors of industries. The matrix could be altered to improve self-properties via silane modifiers by forming chemical linkages with the matrix in harmony with the reinforcing agents. This research work is an endeavor to enhance the traits of Vinyl ester by scrutinizing the influence of silane chemical agents using Hexamethyldisiloxane (HMDS). The dispersion time and concentration of these chemicals in matrix were optimized and henceforth a natural reinforcement, Abaca fabric was incorporated to constitute Natural fiber composite via Vacuum Assisted Resin Transfer Molding (VARTM) technique. The effect of resin modification on mechanical, thermal, and physical properties of Vinyl ester/Abaca (VE/AF) composite was examined. HMDS resin modified composite showed an improvement in the mechanical and flame retardant properties when compared to the pristine composite due to the formation of siloxane bonding which is compatible with the functional groups of both the matrix and the fabric. FT-IR and FESEM characterizations have showed imperative evidences to support the results. This investigation provides a channel for enhancing the properties of natural fiber composites via chemical modification technique. K E Y W O R D SAbaca fibers, flame retardancy, Hexamethyldisiloxane, mechanical properties, Vinyl ester

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“…To allow for smooth plunger movement, these syringes typically are lubricated with silicone oil, which is sprayed onto the interior surfaces of the syringe during the syringe manufacturing process [11]. Although the solubility of silicone oil in typical protein formulations is quite low [12], silicone oil may be present in the formulation in the form of an emulsion. Droplets of emulsified silicone oil may be detected by various optical techniques, but it is often difficult to distinguish silicone oil droplets from aggregates of protein.…”

Section: Introductionmentioning

confidence: 99%

Flow cytometry: A promising technique for the study of silicone oil-induced particulate formation in protein formulations

Ludwig

Trotter

Gabrielson

et al. 2011

Analytical Biochemistry

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Subvisible particles in formulations intended for parenteral administration are of concern in the biopharmaceutical industry. However, monitoring and control of subvisible particulates can be complicated by formulation components, such as the silicone oil used for the lubrication of prefilled syringes, and it is difficult to differentiate microdroplets of silicone oil from particles formed by aggregated protein. In this study, we demonstrate the ability of flow cytometry to resolve mixtures comprising subvisible bovine serum albumin (BSA) aggregate particles and silicone oil emulsion droplets with adsorbed BSA. Flow cytometry was also utilized to investigate the effects of silicone oil emulsions on the stability BSA, lysozyme, abatacept or trastuzumab formulations containing surfactant, sodium chloride or sucrose. To aid in particle characterization, the fluorescence detection capabilities of Flow cytometry were exploited by staining silicone oil with BODIPY® 493/503 and model proteins with Alexa Fluor® 647. Flow cytometric analyses revealed that silicone oil emulsions induced the loss of soluble protein via protein adsorption onto the silicone oil droplet surface. Addition of surfactant prevented protein from adsorbing onto the surface of silicone oil droplets. There was minimal formation of homogeneous protein aggregates due to exposure to silicone oil droplets, although oil droplets with surface-adsorbed trastuzumab exhibited flocculation. The results of this study demonstrate the utility of flow cytometry as an analytical tool for monitoring the effects of subvisible silicone oil droplets on the stability of protein formulations.

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Aqueous solubility of permethylsiloxanes (silicones)

Cited by 105 publications

References 7 publications

Air‐water partition constants for volatile methyl siloxanes

Air‐water partition constants for volatile methyl siloxanes

Influence of silane‐modified Vinyl ester on the properties of Abaca fiber reinforced composites

Flow cytometry: A promising technique for the study of silicone oil-induced particulate formation in protein formulations

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