1990
DOI: 10.1016/0378-5173(90)90130-v
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Aqueous solubilities of some variously substituted quinolone antimicrobials

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Cited by 275 publications
(144 citation statements)
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“…Interestingly, as soon as the solutions containing chitosan were added to the suspensions of the poorly water-soluble ofloxacin, the antibiotic dissolved completely and rapidly. The solubility in aqueous media of fluoroquinolones is considerably increased by decreasing the pH from neutral to slightly acidic 9 . Indeed, Ross and Riley 9 have determined that lowering the pH from 7 to 5 increased the solubility of ofloxacin from 3.23 mg/mL to 95.4 mg/mL.…”
Section: Lachrymal Availability Of Tobramycin and Ofloxacinmentioning
confidence: 99%
See 1 more Smart Citation
“…Interestingly, as soon as the solutions containing chitosan were added to the suspensions of the poorly water-soluble ofloxacin, the antibiotic dissolved completely and rapidly. The solubility in aqueous media of fluoroquinolones is considerably increased by decreasing the pH from neutral to slightly acidic 9 . Indeed, Ross and Riley 9 have determined that lowering the pH from 7 to 5 increased the solubility of ofloxacin from 3.23 mg/mL to 95.4 mg/mL.…”
Section: Lachrymal Availability Of Tobramycin and Ofloxacinmentioning
confidence: 99%
“…The solubility in aqueous media of fluoroquinolones is considerably increased by decreasing the pH from neutral to slightly acidic 9 . Indeed, Ross and Riley 9 have determined that lowering the pH from 7 to 5 increased the solubility of ofloxacin from 3.23 mg/mL to 95.4 mg/mL. Therefore, it is proposed that this solubilization phenomenon is due to the fact that aqueous solutions of chitosan have a pH ranging from 5.5 to 6.5.…”
Section: Lachrymal Availability Of Tobramycin and Ofloxacinmentioning
confidence: 99%
“…Sufficiently sensitive computations tools are needed to fully interpret such complicated systems. Figure 1c shows the logS-pH profile of amifloxacin, an ampholyte which forms a hydrochloride salt below pH 5 [51]. The region of maximum solubility near pH 5 showed supersaturation effects, especially at equilibration times < 24 h. The data in the figure are based on 48 h equilibration time.…”
Section: Atorvastatinmentioning
confidence: 99%
“…Ofloxacin is freely soluble in acetic acid, slightly soluble in water, methanol, ethanol or acetone. The octanol/water partition coefficient for ofloxacin was reported to be -0.48 [1,2] Ofloxacin which is the focus of this review is a second generation fluoroquinolone with a 6-fluoro substituent and a 7-piperazinyl substituent on the quinolone ring structure [11] Entrapped niosomes were prepared by hand shaking and ether injection process with different ratios of (1:1, 1:2 and 1:3) cholesterol and Span-80 (Non-ionic surfactant). The niosomes prepared were in the size of 0.5-2.5 microns in case of hand shaking process and 0.5-2.5 microns in case of Ether injection process.…”
Section: Related Workmentioning
confidence: 99%