Aqueous Microgels for the Growth of Hydroxyapatite Nanocrystals

Abstract

In present article, we demonstrate that aqueous microgels can be used as containers for the in-situ synthesis of hydroxyapatite. The hydroxyapatite nanocrystals (HAp NCs) become integrated into microgels forming hybrid colloids. The HAp NCs loaded in the microgel can be varied over a broad range. The HAp NCs are localized within the microgel corona. The deposition of the inorganic nanocrystals decreases the colloidal stability of the microgels and leads to particle aggregation at high HAp NCs loading. Because of the strong interactions between HAp NCs and polymer chains, the swelling degree of microgels decreases, and temperature-sensitive properties disappear at high loading of the inorganic component. We demonstrate that hybrid colloids can be used as building blocks for the preparation of nanostructured films on solid substrates.

Microgels by Precipitation Polymerization: Synthesis, Characterization, and Functionalization

“…It can be assumed that the efficient fixation of the metal NPs on the PEDOT nanorods is due to the presence of sulfur in the thiophene ring, famous for its strong affinity to Au 0 . Aqueous microgels were modified by hydroxyapatite (HAp) nanocrystals [149]. During the first step, an appropriate amount of Ca(NO 3 ) 2 was dissolved in microgel dispersion and the pH value adjusted to 10 by addition of 25% NH 4 OH.…”

High temporal resolution nanocalorimetry and its combination with micro- and nanofocus x-ray diffraction for study of functional nanostructured materials

“…Микрогели могут находить широкое практическое применение после моди фикации реакционными группами [16,17], поли мерными цепями [18,19], белками [20][21][22], благо родными металлами и оксидами [23][24][25][26][27], а также биоминералами. При помощи модификации водных микрогелей амфифильными лигандами, обладающими клиноподобной формой (рис.4), раз рабатываются новые адаптивные композиционные наноматериа лы (АКНМ).…”

“…The microgels can find wide practical applica tion after modification by the reaction groups [16,17], polymer chains [18,19], proteins [20][21][22], noble metals and oxides [23][24][25][26][27], a nd a l so by biom inera l s. By modification of aqueous micro gels using amphiphilic ligands, having a Vlike shape (Fig.4), the new adaptive composite nano materials (ACNM) are developed. They can be used, for example, for drug delivery.…”

Calcium phosphate/microgel composites for 3D powderbed printing of ceramic materials

“…Our hypothesis is that a combination of calcium phosphate granulate with microgels could have such advantages. In the presence of water, microgels may act as a soft water-based polymer-binding system to connect the calcium phosphate particles via intermolecular-interparticular-hydrogen bonding interactions [40] . Furthermore, the microgels could enhance the mechanical characteristics of printed scaffolds by improving particle bonding and because of their elasticity.…”

“…(B) Schematic illustration of possible interactions between β -TCP and microgels adapted from Schachschal et al[40] . (C) Electrophoretic mobility of 5% VIm MG and pure β -TCP as a function of pH.…”