Aqueous microdroplets containing only ketones or aldehydes undergo Dakin and Baeyer–Villiger reactions

Abstract

The Dakin and Baeyer–Villiger (BV) oxidation reactions require addition of peroxides as oxidants and an acid or a base as a catalyst.

A critical analysis of electrospray techniques for the determination of accelerated rates and mechanisms of chemical reactions in droplets

“…A signicant number of studies have observed that chemical reactions conned in micro-and nano-droplets proceed at signicantly faster rates than those in macroscopic bulk solutions. Several approaches are used to study in-droplet chemistry, which include electrospray (ESI), [1][2][3][4][5][6][7] nano-ESI (nESI) [8][9][10][11][12][13][14] and electrosonic spray (ESSI) [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] ionization mass spectrometry (MS). These techniques produce droplets from a solution containing the reaction mixture, which is then directed towards a MS inlet for chemical characterization.…”

Accelerated microdroplet synthesis of benzimidazoles by nucleophilic addition to protonated carboxylic acids

“…Examples of reactions known to be accelerated in the microdroplet environment include Suzuki coupling, 33 Fisher indole synthesis, 10 Katritzky transamination, 34 Claisen-Schmidt condensation, 35 Eschenmoser coupling, 35 Dakin reaction, 36 Baeyer-Villiger oxidation, 36 N-alkylation of indoles, 37 Combes reaction, 12 Pomeranz-Fritsch synthesis, 12 and cycloaddition reactions. 38 These microdroplet accelerated reactions can be performed under ambient conditions using nESI 10 or, in larger volumes, using electrosonic spray ionization (ESSI).…”

Recent Advances of In‐Source Electrochemical Mass Spectrometry

“…Subsequently, Zare group achieved Dakin and Baeyer-Villiger reactions at room temperature in aqueous microdroplets with no need of external catalysts and peroxides by taking the advantage of in-situ formed H 2 O 2 . [93] Additionally, Dulay et al [94] used this oxidation capability as an effective disinfectant, showing that reactive oxygen species generated from sprayed water microdroplets were capable of inactivating over 98 % of Escherichia coli and Salmonella typhimurium in water.…”

“…It should be noted that H 2 O 2 production was inversely proportional to droplet size, showing the inherent difference between reactions in water microdroplets and bulk‐phase water. Subsequently, Zare group achieved Dakin and Baeyer‐Villiger reactions at room temperature in aqueous microdroplets with no need of external catalysts and peroxides by taking the advantage of in‐situ formed H 2 O 2 [93] . Additionally, Dulay et al [94] .…”