Aqueous Methanol Extracts of Cochlospermum tinctorium (A. Rich) Possess Analgesic and Anti-inflammatory Activities

Ahmed, Tauqeer; Magaji, Mohammed Garba; Yaro, Alpha Seydou; Musa, A. M.; Adamu, A. K.

doi:10.4103/0975-1483.83774

Cited by 17 publications

(17 citation statements)

References 23 publications

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“…Intraperitoneal injection of acetic acid has been reported to significantly increase level of prostanoids, particularly PGE 2 and PGF 2α as well as lipoxygenase products in the peritoneal fluid (Ahmed et al, 2011;Ricciotti and FitzGerald, 2011). Regarding this test, our results clarified that the hexane extract from H. brasiliana (Figure 1) presented antinociceptive property by reducing abdominal writhing based on this explanation.…”

Section: Discussionsupporting

confidence: 64%

Antinociceptive and anti-inflammatory activities of the hexane extract from Hortia brasiliana Vand. leaves on experimental animal models

Magalhatilde;es¹

2013

Afr. J. Pharm. Pharmacol.

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Antinociceptive and anti-inflammatory activities of the hexane extract from Hortia brasiliana Vand. leaves were investigated by experimental animal models. Guaiol (9.72%), nonacosane (25.57%) and eicosane (10.80%) were the most abundant components identified by GC/MS. The extract, with LD 50 of 2.40 g/kg, reduced the number of abdominal contortions by 13.86 (100 mg/kg) and 18.51% (200 mg/kg). Doses of 100 and 200 mg/kg inhibited both phases of the time paw licking: First phase (9.44% and 16.32%) and the second phase (11.97 and 23.49%), respectively. The extract increased the reaction time on a hot plate at doses of 100 (24.92%) and 200 mg/kg (55.69%) after 90 min of treatment. The paw edema was reduced by the hexane extract at doses of 100 (10.42 and 8.23%) and 200 mg/kg (15.62 and 17.65%) after 3 to 4 h of application of carrageenan, respectively. At the dose of 200 mg/kg, the extract reduced the exudate volume by 19.44%, while the leucocyte migration was inhibited at the doses of 100 and 200 mg/kg (6.13 and 13.84%, respectively). These results suggest that H. brasiliana can be an active source of substances with antinociceptive and anti-inflammatory activities supporting the use in the Brazilian folk medicine.

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Section: Discussionsupporting

confidence: 64%

Antinociceptive and anti-inflammatory activities of the hexane extract from Hortia brasiliana Vand. leaves on experimental animal models

Magalhatilde;es¹

2013

Afr. J. Pharm. Pharmacol.

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“…11 (3) 2016 341 dependently inhibited the acetic acid induced writhing in mice. The highest protection was produced by the aqueous methanol extract (80 mg/kg); the same extract significantly and dose-dependently inhibited carrageenan-induced hind paw edema in the rat [40].…”

Section: Cochlospermum Tinctorium Perrex a Rich (Cochlospermaceae)mentioning

confidence: 93%

Medicinal Plants Used in Mali for the Treatment of Malaria and Liver Diseases

Haïdara

Bourdy

Tommasi

et al. 2016

Natural Product Communications

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Today, ethno-pharmacology is a very important resource in order to discover new therapies for the current diseases. Moreover, another good justification for the ethno-pharmacological approach is to obtain new, effective, less expensive and simple therapies, limiting at the same time the cost of pharmaceutical research. Two major anti-malarial drugs widely used today, i.e. quinine and artemisinin, came respectively from Peruvian and Chinese ancestral treatments reported in the traditional medicines. In this contest, there is an urgent need for the discovery of new drugs, due to the critical epidemiological situation of this disease and to the growth of resistances. In Mali, malaria and liver diseases remain one of the leading public health problems. Many medicinal plants are often used, in local traditional medicine, for the treatment at the same time of malaria and liver diseases, including hepatic syndromes, jaundice, hepatitis and other hepatic disorders. Moreover, in the local language Bamanan, the word “ Sumaya” is used both for malaria and some liver diseases. In addition, we noted that some of the improved traditional phytomedicines produced by the Department of Traditional Medicine are prescribed by modern doctors both for malaria and liver diseases. In this review, pharmacological, toxicological and phytochemical data on Argemone mexicana L. (Papaveraceae), Cochlospermum tinctorium Perr. ex A. Rich (Cochlospermaceae), Combretum micranthum G.Don (Combretaceae), Entada africana Guillet Perr. (Mimosaceae), Erythrina senegalensis A. DC (Fabaceae), Mitragyna inermis (Willd) Kuntze (Rubiaceae), Nauclea latifolia Smith syn. Sarcocephalus latifolius (Smith) Bruce (Rubiaceae), Securidaca longepedunculata Fresen (Polygalaceae), Trichilia emetica Vahl. (Meliaceae), and Vernonia colorata (Willd) Drake (Asteraceae) are reported. Some of the collected data could be used to improve the actual herbal drugs and to propose new phytomedicines for the management of malaria and liver diseases.

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“…[ 32 ] Increased level of eicosanoids (Prostaglandin E 2 , Prostaglandin F 2 α and Leukotrienes) has been found in the peritoneal fluid after intraperitoneal injection of acetic acid. [ 33 ] The analgesic effect of the extract may therefore be due either to its action on visceral receptors sensitive to acetic acid or to the inhibition of the production of algogenic substances or the inhibition at the central level of the transmission of painful messages.…”

Section: Discussionmentioning

confidence: 99%

Analgesic and hypnotic activities of Laghupanchamula: A preclinical study

Ghildiyal

Gautam

Joshi

et al. 2014

AYU

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Background:In Ayurvedic classics, two types of Laghupanchamula -five plant roots (LP) have been mentioned containing four common plants viz. Kantakari, Brihati, Shalaparni, and Prinshniparni and the fifth plant is either Gokshura (LPG) or Eranda (LPE). LP has been documented to have Shothahara (anti-inflammatory), Shulanashka (analgesic), Jvarahara (antipyretic), and Rasayana (rejuvenator) activities.Aim:To evaluate the acute toxicity (in mice), analgesic and hypnotic activity (in rats) of 50% ethanolic extract of LPG (LPGE) and LPE (LPEE).Materials and Methods:LPEG and LPEE were prepared separately by using 50% ethanol following the standard procedures. A graded dose (250, 500 and 1000 mg/kg) response study for both LPEE and LPGE was carried out for analgesic activity against rat tail flick response which indicated 500 mg/kg as the optimal effective analgesic dose. Hence, 500 mg/kg dose of LPEE and LPGE was used for hot plate test and acetic acid induced writhing model in analgesic activity and for evaluation of hypnotic activity.Results:Both the extracts did not produce any acute toxicity in mice at single oral dose of 2.0 g/kg. Both LPGE and LPEE (250, 500, and 1000 mg/kg) showed dose-dependent elevation in pain threshold and peak analgesic effect at 60 min as evidenced by increased latency period in tail-flick method by 25.1-62.4% and 38.2-79.0% respectively. LPGE and LPEE (500 mg/kg) increased reaction time in hot-plate test at peak 60 min analgesic effect by 63.2 and 85.8% and reduction in the number of acetic acid-induced writhes by 55.9 and 65.8% respectively. Both potentiated pentobarbitone-induced hypnosis as indicated by increased duration of sleep in treated rats.Conclusion:The analgesic and hypnotic effects of LP formulations authenticate their uses in Ayurvedic system of Medicine for painful conditions.

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Aqueous Methanol Extracts of Cochlospermum tinctorium (A. Rich) Possess Analgesic and Anti-inflammatory Activities

Cited by 17 publications

References 23 publications

Antinociceptive and anti-inflammatory activities of the hexane extract from Hortia brasiliana Vand. leaves on experimental animal models

Antinociceptive and anti-inflammatory activities of the hexane extract from Hortia brasiliana Vand. leaves on experimental animal models

Medicinal Plants Used in Mali for the Treatment of Malaria and Liver Diseases

Analgesic and hypnotic activities of Laghupanchamula: A preclinical study

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