“…The high concentration of ascorbate in the aqueous humor (1 . 1 mM) is certainly suf®cient to support the reaction (Berman, 1991). In vitro studies have shown that AL-3037A is able to degrade hyaluronan at ascorbate concentrations 10 times lower than that found in the aqueous humor.…”
“…The high concentration of ascorbate in the aqueous humor (1 . 1 mM) is certainly suf®cient to support the reaction (Berman, 1991). In vitro studies have shown that AL-3037A is able to degrade hyaluronan at ascorbate concentrations 10 times lower than that found in the aqueous humor.…”
“…Tables 1, 2 Adapted from: (Cooper et al, 1984) ; a (Trope and Rumley, 1985). (Tripathi et al, 1989); b (Inada et al, 1984); c (Berman, 1991) Adapted from: (Riley, 1983); a (Spector and Garner, 1981); b (Davson, 1969) …”
Section: Composition Of the Aqueous Humormentioning
“…26 -29 In addition, aqueous humor also contains proteins and other molecules secreted from anterior segment tissues. 26,30,31 Aqueous humor also differs from fetal bovine serum in both the types and proportions of proteins and growth factors. The use of aqueous humor as a medium supplement in vitro for primary trabecular cell culture models is not a common practice.…”
Addition of human aqueous humor rather than FBS to trabecular monolayer cell cultures triggers significant changes in cellular and molecular characteristics. The protein component of aqueous humor is responsible for these changes. Aqueous humor supplementation may maintain cultured trabecular cells in a more physiologic state.
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