Aqueous Humor Erythropoietin Levels in Patients With Primary Open-angle Glaucoma

Cumurcu, Tongabay; Bulut, Yunus Emre; Demir, Helin Deniz; Yenişehirli, Gülgün

doi:10.1097/ijg.0b013e31804a5eb3

Cited by 33 publications

(25 citation statements)

References 28 publications

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“…Becerra and Amaral (93) hypothesized that identifi cation and separation of the structural determinants within the erythropoietin molecule could elucidate additional ways to minimize side effects associated with local administration of erythropoietin to the eye, an approach that offers advantages over systemic administration. Recently, the role of AH erythropoietin in POAG has been investigated, and the studies have concluded that erythropoietin is a possible biomarker for the disease (61,94,95) .…”

Section: Erythropoietinmentioning

confidence: 99%

Biomarkers in primary open angle glaucoma

Kokotas

Kroupis

Chiras

et al. 2012

Clinical Chemistry and Laboratory Medicine (CCLM)

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Glaucoma, a leading cause of blindness worldwide, is currently defi ned as a disturbance of the structural or functional integrity of the optic nerve that causes characteristic atrophic changes in the optic nerve, which may lead to specifi c visual fi eld defects over time. This disturbance usually can be arrested or diminished by adequate lowering of intraocular pressure (IOP). Glaucoma can be divided roughly into two main categories, ' open angle ' and ' closed angle ' glaucoma. Open angle, chronic glaucoma tends to progress at a slower rate and patients may not notice loss of vision until the disease has progressed signifi cantly. Primary open angle glaucoma (POAG) is described distinctly as a multifactorial optic neuropathy that is chronic and progressive with a characteristic acquired loss of optic nerve fi bers. Such loss develops in the presence of open anterior chamber angles, characteristic visual fi eld abnormalities, and IOP that is too high for the healthy eye. It manifests by cupping and atrophy of the optic disc, in the absence of other known causes of glaucomatous disease. Several biological markers have been implicated with the disease. The purpose of this study was to summarize the current knowledge regarding the non-genetic molecular markers which have been predicted to have an association with POAG but have not yet been validated.

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Section: Erythropoietinmentioning

confidence: 99%

Biomarkers in primary open angle glaucoma

Kokotas

Kroupis

Chiras

et al. 2012

Clinical Chemistry and Laboratory Medicine (CCLM)

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“…reported a statistically significant decrease in retinal EPO levels 48 and 72 h after acute ischemia-reperfusion damage in their experimental glaucoma-ischemia model in rats. Cumurcu et al [18]. showed that the aqueous humor EPO concentration in eyes with POAG (10.91 ± 4.32 mU/ml) was significantly higher than that in eyes with cataract (8.24 ± 1.77 mU/ml), and they suggested that EPO could play a role in glaucoma pathogenesis.…”

Section: Discussionmentioning

confidence: 96%

“…In the field of glaucoma there are also some studies which can be seen as proof of its neuroprotective effect [12,[22][23][24], although they were confined to animal models [22][23][24]. Only one study has investigated EPO levels in aqueous humor of primary open angle glaucoma (POAG) patients, and showed higher levels in the POAG group [18].…”

Section: Introductionmentioning

confidence: 97%

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Aqueous humor and serum erythropoietin levels in patients with pseudoexfoliation syndrome and pseudoexfoliative glaucoma

et al. 2010

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A prospective, non-randomized, comparative study was carried out to investigate aqueous humor and serum erythropoietin (EPO) levels in patients with pseudoexfoliation syndrome (PXS), pseudoexfoliative glaucoma (PXG), and, as controls, senile cataract without glaucoma. Aqueous humor was aspirated at the beginning of cataract or combined glaucoma-cataract surgery from 24 patients with PXS, 24 patients with PXG, and 24 patients with cataract only. Venous blood samples were obtained from all patients at the same time. Levels of EPO were measured in aqueous humor and venous blood using a sandwich enzyme-linked immunosorbent assay (ELISA) kit. There was no statistically significant difference between the mean aqueous humor EPO concentrations in eyes with PXS (10.70 ± 7.18 mU/ml), PXG (10.18 ± 7.20 mU/ml) and controls (9.75 ± 5.04 mU/ml) (P = 0.732). There was no statistically significant difference between the mean serum EPO concentrations in eyes with PXS (6.32 ± 2.86 mU/ml), PXG (7.06 ± 4.35 mU/ml) and controls (7.30 ± 4.15 mU/ml) (P = 0.672). Contrary to predictions based on the relation with ischemic processes, no difference was revealed between levels of EPO in aqueous humor and serum in patients with PXS and PXG.

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“…EPO is expressed at a number of sites including the kidney, liver, neural tissue, female genital tract, placenta, testis and the adult mammalian retina, which also expresses EPO receptors [4] . Furthermore, it is present in aqueous humor and vitreous, and its concentration in the eye is increased in retinopathy of prematurity [5] , branch retinal vein occlusion [6] , proliferative diabetic retinopathy [6,7] , diabetic macular edema [8,9] and primary open-angle glaucoma) [10] . Recently, an experimental study showed that the levels of EPO in detached retina increase with the duration of RD [11] , but we have not come across a study showing the vitreous EPO levels of RRD and PVR patients.…”

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confidence: 99%

Elevated Erythropoietin in Vitreous of Patients with Rhegmatogenous Retinal Detachment and Proliferative Vitreoretinopathy

et al. 2009

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Aim: Our purpose was to determine the vitreous erythropoietin (EPO) level in patients with rhegmatogenous retinal detachment (RRD) and proliferative vitreoretinopathy (PVR). Methods: The levels of EPO in vitreous were measured using a sandwich enzyme-linked immunosorbent assay kit from 64 patients, of whom 40 had RRD, 13 had PVR and 11 had idiopathic macular hole as control. Results: The mean levels of EPO in the RRD group (54.6 ± 7.3 mU/ml) and PVR group (104.1 ± 20.8 mU/ml) were significantly higher than that in the idiopathic macular hole control group (14.4 ± 3.6 mU/ml; p < 0.001, p = 0.003, respectively). The mean EPO level in PVR was higher than that in RRD, but the difference was not significant (p = 0.112). Conclusion: The vitreous EPO level was upregulated in eyes with RRD and PVR.

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Aqueous Humor Erythropoietin Levels in Patients With Primary Open-angle Glaucoma

Abstract: The aqueous humor EPO level is increased in eyes with POAG.

Cited by 33 publications

References 28 publications

Biomarkers in primary open angle glaucoma

Biomarkers in primary open angle glaucoma

Aqueous humor and serum erythropoietin levels in patients with pseudoexfoliation syndrome and pseudoexfoliative glaucoma

Elevated Erythropoietin in Vitreous of Patients with Rhegmatogenous Retinal Detachment and Proliferative Vitreoretinopathy

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