Aqueous gold nanosols stabilized by electrostatic protection generated by X-ray irradiation assisted radical reduction

Wang, Changhai; Hua, Tzu-En; Chien, Chia‐Chi; Yu, Yanhua; Yang, Tsung-Yeh; Liu, Chi-Jen; Leng, Wei-Hua; Hwu, Y.; Yang, Yaxiong; Kim, Chong-Cook; Je, J. H.; Chen, Chih‐Hsiung; Li, Hongming; Margaritondo, G.

doi:10.1016/j.matchemphys.2007.06.024

Cited by 44 publications

(23 citation statements)

References 20 publications

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“…We used two types of AuNPs: bare AuNPs and MUA-AuNPs; both types we extensively tested33343536. The one-pot, reducing agent free synthesis produced clean and monodisperse AuNPs with high colloidal stability.…”

Section: Resultsmentioning

confidence: 99%

X-ray imaging of tumor growth in live mice by detecting gold-nanoparticle-loaded cells

Chien

Chen

Lai

et al. 2012

Sci Rep

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We show that sufficient concentrations of gold nanoparticles produced by an original synthesis method in EMT-6 and CT-26 cancer cells make it possible to detect the presence, necrosis and proliferation of such cells after inoculation in live mice. We first demonstrated that the nanoparticles do not interfere with the proliferation process. Then, we observed significant differences in the tumor evolution and the angiogenesis process after shallow and deep inoculation. A direct comparison with pathology optical images illustrates the effectiveness of this approach.

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Section: Resultsmentioning

confidence: 99%

X-ray imaging of tumor growth in live mice by detecting gold-nanoparticle-loaded cells

Chien

Chen

Lai

et al. 2012

Sci Rep

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“…Our previous work [37][38][39][40] had developed a new approach to prepare highly concentrated colloidal gold solutions free of reducing agents and stabilizers by roomtemperature synchrotron x-ray irradiation.…”

Section: Characterization Of Pegylated Gold Nanoparticlesmentioning

confidence: 99%

Optimizing the size and surface properties of polyethylene glycol (PEG)–gold nanoparticles by intense x-ray irradiation

Wang

Liu

Wang

et al. 2008

J. Phys. D: Appl. Phys.

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The polyethylene glycol (PEG) modified gold nanoparticle complex was synthesized by a one-solution synchrotron x-ray irradiation method. The impact on the structure and morphology of the gold nanoparticles of process parameters such as the PEG molecular weight, the PEG/gold molar ratio and the x-ray dosage were investigated. The size of PEG modified gold particles was found to decrease with increasing PEG addition and x-ray dosage. With the capability to monitor the absorption spectra in situ during the fast synthesis process, this opens the way to accurate control of the size and distribution. PEG chains with an intermediate length (MW6000) were found optimal for size control and colloidal stability in biologically relevant media. Our x-ray synthesized PEG-gold nanoparticles could find interesting applications in nanoparticle-enhanced x-ray tumour imaging and therapy.

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“…2(a)] where some particles have the tendency to aggregate resulting from a decrease in GNPs stability. 29,30 In fact, the optical properties of the metallic nanoparticles are mainly determined by two contributions: the properties of the particles acting as well-isolated individuals and the collective properties of the whole ensemble. When individual spherical GNPs come into close proximity to one another, the interparticle coupling becomes more effective depending on size and shape of the formed aggregates (Ref.…”

Section: Discussionmentioning

confidence: 99%

Laser-induced modifications of gold nanoparticles and their cytotoxic effect

et al. 2012

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Abstract. As nanotechnology continues to develop, an assessment of nanoparticles' toxicity becomes very crucial for biomedical applications. The current study examines the deleterious effects of pre-irradiated gold nanoparticles (GNPs) solutions on primary rat kidney cells (PRKCs). Spectroscopic and transmission electron microscopic studies demonstrated that exposure of 15 nm GNPs in size to pulsed laser caused a reduction both in optical density and mean particle diameter. GNPs showed an aggregation when added to the cell culture medium (DMEM). This aggregation was markedly decreased upon adding serum to the medium. Under our experimental conditions, trypan blue and MTT assays revealed no significant changes in cell viability when PRKCs were incubated with non-irradiated GNPs over a period of 72 h and up to 4 nM GNPs concentration. On the contrary, when cells were incubated with irradiated GNPs a significant reduction in PRKCs viability was revealed.

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Aqueous gold nanosols stabilized by electrostatic protection generated by X-ray irradiation assisted radical reduction

Cited by 44 publications

References 20 publications

X-ray imaging of tumor growth in live mice by detecting gold-nanoparticle-loaded cells

X-ray imaging of tumor growth in live mice by detecting gold-nanoparticle-loaded cells

Optimizing the size and surface properties of polyethylene glycol (PEG)–gold nanoparticles by intense x-ray irradiation

Laser-induced modifications of gold nanoparticles and their cytotoxic effect

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