Aqueous fullerene C<sub>60</sub> solution suppresses herpes simplex virus and cytomegalovirus infections

Климова, Р. Р.; Андреев, С. М.; Momotyuk, Ekaterina; Demidova, N. A.; Федорова, Н. Е.; Chernoryzh, Yana Yu; Yurlov, K.I.; Turetskiy, Evgeniy A.; Барабошкина, Е Н; Shershakova, Nadezhda N.; Simonov, Ruslan A.; Кущ, А А; Khaitov, Musa; Gintsburg, A. L.

doi:10.1080/1536383x.2019.1706495

Cited by 18 publications

(12 citation statements)

References 41 publications

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“…The latter minimizes the amount of the initial solvent in the final aqueous system. This aqueous liquid system turned out effective for inhibiting the herpes virus and cytomegalovirus infection [85]. The anti-inflammatory effect was also demonstrated in the case of the mice model of atopic dermatitis [86].…”

Section: Toxicity Of Aqueous Liquid Systems With Fullerenes: Main Aspmentioning

confidence: 89%

Liquid Systems with Fullerenes in Organic Solvents and Aqueous Media

Kyzyma

2020

Ukr. J. Phys.

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The unique properties of nanocarbon materials – in particular, fullerenes – has led in recent years to the expansion of the spectrum of their application in various fields of the industry, including the chemical, energy, and pharmaceutical ones. The use of fullerenes in new industries poses new challenges to the scientific and research community. Thus, new methods of obtaining biocompatible liquid systems with small-sized monodisperse fullerene aggregates are still being sought. The paper focuses on the properties of fullerene solutions in mixtures of organic solvents, which serve as a basis for the development of new methods for synthesizing the aqueous liquid systems with fullerenes.

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Section: Toxicity Of Aqueous Liquid Systems With Fullerenes: Main Aspmentioning

confidence: 89%

Liquid Systems with Fullerenes in Organic Solvents and Aqueous Media

Kyzyma

2020

Ukr. J. Phys.

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“…Functionalized fullerene molecules can be utilized as platforms for drug delivery [60] , promising antiviral [61] , and antitumor drugs [62] . For example, the soluble fullerene derivatives can be used as anti-HIV drugs inhibiting viral replication [63] . Moreover, the functionalized fullerene derivatives have been widely investigated for antitumor effects on brain or lung cancer cells in recent years [52] , [58] .…”

Section: Discussionmentioning

confidence: 99%

Identification of potential descriptors of water-soluble fullerene derivatives responsible for antitumor effects on lung cancer cells via QSAR analysis

Huang

Chetyrkina

Wong

et al. 2021

Computational and Structural Biotechnology Journal

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Graphical abstract A series of water-soluble fullerene derivatives are synthesized to produce antitumor effects on three types of lung cancer cells. The fullerene compounds with sulfur-containing aromatic rings showed the most effective inhibition on cell proliferation among all fullerene compounds. The quantitative structure–activity relationship (QSAR) models illustrate that thiophene moiety in the fullerene cage has positive correlation with the antitumor effect of the fullerene derivatives.

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“…Конъюгат фуллерена с углеводами снижал патогенность вируса Эбола, связывая лектин DC-SIGN на макрофагах человека [51,52]. Водорастворимый комплекс фуллерена с N-метилпирролидоном (ВРФ) демонстрировал выраженный противовирусный эффект относительно вирусов простого герпеса (HSV) 1-го и 2-го типа, а также цитомегаловируса человека (HCMV) [53]. Несмотря на то что механизм действия фуллерена С60 остается пока не совсем ясным, есть предположение, что эффекты фуллерена могут быть связаны с его антиоксидантной активностью и частично с его способностью непосредственно взаимодействовать с белками вируса, обусловливая вирулицидный эффект.…”

Section: другие перспективные ингибиторыunclassified

Promising compounds from natural sources against COVID-19

Андреев¹,

Shershakova²,

Kozhikhova³

et al. 2020

Russian Journal of Allergy

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The epidemic associated with the new Sars-CoV-2 coronavirus has affected almost all countries of the world and no reliable treatment for this infection exists yet. Many laboratories in the world are currently conducting intensive experimental and theoretical/in silico studies to find effective drugs specific for this disease (COVID-19), but unfortunately, it may take a long time before new drugs appear in the clinical practice. One of the currently widely accepted approaches for finding active compounds is based on the possibility of using existing drugs approved by government medical organizations (as the FDA). Their choice is based on screening, based on the use of computer models that evaluate the specific binding (energy minimization) of such drugs to target molecules that are important for the life cycle. Thus, a few well-known antiviral drugs against HIV, hepatitis C and others selected on this basis exerted an antiviral effect in vitro, but their real effectiveness was far from expected. It should be emphasized that the severe clinical manifestation of the disease is an acute respiratory distress syndrome, mediated by oxidative stress and an aggressive immune attack on its own cells. In this regard, the use of compounds with high antioxidant activity could have advantages both prophylactically and medically. There is a huge range of natural compounds, including official and traditional medicine, which represent valuable unlimited potential for COVID-19 therapy, the advantage of such compounds in their low toxicity. In this review, we tried to focus on the clinical and pharmacological properties of natural substances, mainly flavonoids, which can become promising drugs for the treatment and prevention of COVID-19. The review includes information on possible virus targets and antiviral drugs. Much attention is paid to the question of inhibition of viral activity. Based on published data, including structural features of various compounds, a prediction is made about the prospects of using these compounds as inhibitors of viral activity, as well as anti-inflammatory drugs for the treatment of COVID-19. An important step in the analysis of compounds was the study of the possibility of their interaction with cellular targets of the virus, as well as the ability to bind to the proteins of the Sars-CoV-2 virus itself.

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Aqueous fullerene C₆₀ solution suppresses herpes simplex virus and cytomegalovirus infections

Cited by 18 publications

References 41 publications

Liquid Systems with Fullerenes in Organic Solvents and Aqueous Media

Liquid Systems with Fullerenes in Organic Solvents and Aqueous Media

Identification of potential descriptors of water-soluble fullerene derivatives responsible for antitumor effects on lung cancer cells via QSAR analysis

Promising compounds from natural sources against COVID-19

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Aqueous fullerene C60 solution suppresses herpes simplex virus and cytomegalovirus infections

Cited by 18 publications

References 41 publications

Liquid Systems with Fullerenes in Organic Solvents and Aqueous Media

Liquid Systems with Fullerenes in Organic Solvents and Aqueous Media

Identification of potential descriptors of water-soluble fullerene derivatives responsible for antitumor effects on lung cancer cells via QSAR analysis

Promising compounds from natural sources against COVID-19

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Aqueous fullerene C₆₀ solution suppresses herpes simplex virus and cytomegalovirus infections