Aqueous extracts of two tropical ethnobotanicals (Tetrapleura tetraptera and Quassia undulata) improved spatial and non-spatial working memories in scopolamine-induced amnesic rats: Influence of neuronal cholinergic and antioxidant systems

Odubanjo, Veronica O.; Ibukun, Emmanuel Oluwafemi; Oboh, Ganiyu; Adefegha, Stephen A.

doi:10.1016/j.biopha.2018.01.043

Cited by 28 publications

(17 citation statements)

References 35 publications

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“…However, A. paniculata extract inhibited AChE and BChE activities which could be partly related to some of the phytochemicals present. This supports earlier reports where medicinal plants inhibited cholinesterase activities in vitro and in vivo (Ajiboye et al, 2018;Odubanjo et al, 2017).…”

Section: Discussionsupporting

confidence: 92%

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Effect of Andrographis paniculata leaves extract on neurobehavioral and biochemical indices in scopolamine‐induced amnesic rats

et al. 2020

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The brain plays a major role in the central nervous system (CNS) and an important organ of the body that controls the functions of all other organs with the aid of neurons through signal transmission, whereas, in neurodegeneration, the functions of these neurons are impaired or altered (Ortman, Velkoff, & Hogan, 2014). Neurodegeneration is a process that refers to any pathology that mainly affects the neurons gradually. This condition alters the structure and function of neurons which leads to increased neuronal death, poor decision making, loss

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Section: Discussionsupporting

confidence: 92%

“…All procedures were approved by the Ethical Committee, Federal University of Technology, Akure, Nigeria (Ethical number: FUTA/SOS/1414). The behavioral test (Morris Water Maze and Y‐maze) was done 1 hr after scopolamine administration (Odubanjo, Ibukun, Oboh, & Adefegha, 2017).…”

Section: Methodsmentioning

confidence: 99%

Effect of Andrographis paniculata leaves extract on neurobehavioral and biochemical indices in scopolamine‐induced amnesic rats

et al. 2020

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“…All of these compounds have already been detected in aqueous, methanol and ethanol extracts of T. tetraptera (Sokamte et al, 2019;Odubanjo et al, 2018;Amadi et al, 2016), but the amounts recorded are lower than the quantities already published for aqueous extracts. Among the phenolic and aromatic compounds identified and quantified for the plant species, the presence of Kojic acid, Cyanidin chloride, Myricetin, Salicylic acid, Mangeferin, Naringin and Protocatechic acid has not yet been reported for the two plant species.…”

Section: Identification and Quantification Of Phenolic And Heterocyclmentioning

confidence: 58%

Hypoglycaemic activity of preheated (roasting) Aframomum citratum (C. Pereira) K. Schum and Tetrapleura tetraptera (Schumach Thonn.) fruits beverage on Streptozotocin-induced rats

Eyenga¹,

Takuissu²,

Ziyyat³

et al. 2020

J. Pharmacognosy Phytother.

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Tetrapleura tetraptera and Aframomum citratum fruits are used as spices and in the traditional pharmacopeia in Cameroon. They are mostly combined and preheated for many purposes while cooking. The effects of roasting on the phenolic content of spices, phenolic profile of a beverage made with the mix of roasted spices and its hypoglycaemic activity on diabetes complications were investigated. Aqueous extract (infusion: 100°C; 1/5 g/ml) was prepared, and the total polyphenols and flavonoids contents before and after heat treatment were quantified. Four formulations of T. tetraptera/A. citratum (95/5; 90/10; 85/15; 80/20) were assessed and the in vitro glucose adsorption capacity of the extracts was studied to retain the most effective formulation (AEF). Phenolic and derivatives compounds of AEF were analysed using HPLC-DAD methodology. The AEF hypoglycaemic activity (250 mg/kg bw) and the various complications of hyperglycaemia after Streptozotocin induction (55 mg/kg) were examined on rats. Significant (p<0.05) improvements in phytochemical content were noticed for T. tetraptera and AEF extracts after heat treatment. Among the phenolic compounds identified, flavone, protocatechic, chlorogenic, p-Coumaric acids, and naringin showed the highest concentrations. Significantly, the effect of AEF is the same as the administration of AEF-Glibenclamide (Glibenclamide) and Acarbose after 4 h when assessing the anti-hyperglycaemic test. The influence of Glibenclamide (the reference drug) is significantly improved by AEF, and this synergy has the best antihyperglycaemic, hypoglycaemic, hypotriglyceridaemic potential and boosts catalase, superoxide dismutase activities while reducing Malondialdehyde (liver, pancreas, haemolysates) and hydroperoxide (liver, plasma, and kidney) contents compared with the use of single AEF.

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“…Indeed, an aqueous decoction of mango ( Mangifera indica L.) stem bark has been developed on an industrial scale to be used as a nutritional supplement, cosmetic, and as a nutraceutical with neuroprotective effects [68,85,86]. Furthermore, neuroprotective effects of Moringa oleifera seed extract [52,53] and likewise T. tetraptera have also been demonstrated [48].…”

Section: Discussionmentioning

confidence: 99%

“…The dried fruit is used as a seasoning spice in the Southern part of Nigeria [46,47] and in the Niger Delta areas, the pod, fruit, and seeds are used as spices. A neuroprotective effect of T. tetraptera has been reported in scopolamine-induced amnesic rats [48].…”

Section: Introductionmentioning

confidence: 99%

An Investigation of Potential Sources of Nutraceuticals from the Niger Delta Areas, Nigeria for Attenuating Oxidative Stress

et al. 2019

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Background: Diets rich in fruits, vegetables, and medicinal plants possess antioxidants potentially capable of mitigating cellular oxidative stress. This study investigated the antioxidant, anti-acetylcholinesterase (AChE), and total phenolic and flavonoids contents (TPC/TFC) of dietary sources traditionally used for memory enhancing in Niger Delta, Nigeria. Methods: Dacroydes edulis methanolic seed extract (DEMSE), Cola lepidota methanolic seed extract (CLMSE), Terminalia catappa methanolic seed extract (TeCMSE), Tricosanthes cucumerina methanolic seed extract (TrCMSE), Tetrapleura tetraptera methanolic seed extract (TTMSE), and defatted Moringa oleifera methanolic seed extract (DMOMSE); Dennettia tripetala methanolic fruit extract (DTMFE), Artocarpus communis methanolic fruit extract (ACMFE), Gnetum africana methanolic leaf extract (GAMLE), Musa paradisiaca methanolic stembark extract (MPMSE), and Mangifera indica methanolic stembark extract (MIMSE) were evaluated for free radical scavenging antioxidant ability using 2,2-Diphenyl-1-picrylhydrazyl (DPPH), reducing power capacity (reduction of ferric iron to ferrous iron), AChE inhibitory potential by Ellman assay, and then TPC/TFC contents determined by estimating milli-equivalents of Gallic acid and Quercetin per gram, respectively. Results: The radical scavenging percentages were as follows: MIMSE (58%), MPMSE (50%), TrCMSE (42%), GAMLE (40%), CLMSE (40%), DMOMSE (38%), and DEMFE (37%) relative to β-tocopherol (98%). The highest iron reducing (antioxidant) capacity was by TrCMSE (52%), MIMSE (40%) and GAMLE (38%). Extracts of MIMSE, TrCMSE, DTMFE, TTMSE, and CLMSE exhibited concentration-dependent AChE inhibitory activity (p < 0.05–0.001). At a concentration of 200 µg/mL, the AChE inhibitory activity and IC50 (µg/mL) exhibited by the most potent extracts were: MIMSE (≈50%/111.9), TrCMSE (≈47%/201.2), DTMFE (≈32%/529.9), TTMSE (≈26%/495.4), and CLMSE (≈25%/438.4). The highest TPC were from MIMSE (156.2), TrCMSE (132.65), GAMLE (123.26), and CLMSE (119.63) in mg gallic acid equivalents/g, and for TFC were: MISME (87.35), GAMLE (73.26), ACMFE (69.54), CLMSE (68.35), and TCMSE2 (64.34) mg quercetin equivalents/gram. Conclusions: The results suggest that certain inedible and edible foodstuffs, most notably MIMSE, MPMSE, TrCMSE, GAMLE, and CLMSE may be beneficial to ameliorate the potentially damaging effects of redox stress.

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Aqueous extracts of two tropical ethnobotanicals (Tetrapleura tetraptera and Quassia undulata) improved spatial and non-spatial working memories in scopolamine-induced amnesic rats: Influence of neuronal cholinergic and antioxidant systems

Cited by 28 publications

References 35 publications

Effect of Andrographis paniculata leaves extract on neurobehavioral and biochemical indices in scopolamine‐induced amnesic rats

Effect of Andrographis paniculata leaves extract on neurobehavioral and biochemical indices in scopolamine‐induced amnesic rats

Hypoglycaemic activity of preheated (roasting) Aframomum citratum (C. Pereira) K. Schum and Tetrapleura tetraptera (Schumach Thonn.) fruits beverage on Streptozotocin-induced rats

An Investigation of Potential Sources of Nutraceuticals from the Niger Delta Areas, Nigeria for Attenuating Oxidative Stress

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