Aqueous extracts of avocado pear (<i>Persea americana</i> Mill.) leaves and seeds exhibit anti-cholinesterases and antioxidant activities in vitro

Oboh, Ganiyu; Odubanjo, Veronica O.; Bello, Fatai; Ademosun, Ayokunle O.; Oyeleye, Sunday I.; Nwanna, Emem E; Ademiluyi, Adedayo O.

doi:10.1515/jbcpp-2015-0049

Cited by 66 publications

(39 citation statements)

References 41 publications

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“…) and the seed and leaf of Avocado (Oboh et al . ). The phenolic compositions and quantification by HPLC–DAD of the studied plants revealed the presence of five phenolic acids and six flavonoids which was higher when compared to the number of phenolic components found in the Prunus spinosa as reported by Aliyazicioglu et al .…”

Section: Discussionmentioning

confidence: 97%

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Cognitive Enhancing and Antioxidative Potentials of Velvet Beans (Mucuna pruriens) and Horseradish (Moringa oleifera) Seeds Extracts: A Comparative Study

Adefegha

Oboh

Oyeleye

et al. 2016

Journal of Food Biochemistry

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Velvet beans and Horseradish seeds are widely consumed as food, and use in folklore for the treatment of cognitive dysfunction although with limited information on their mechanisms of action. This study investigated and compared the effects of aqueous extracts of these seeds on the cholinergic [acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)] and monoaminergic [monoamine oxidase (MAO)] enzymes and FeSO4‐induced thiobarbituric acid reactive species (TBARS) in isolated rat brain homogenate. Results revealed that both extracts inhibited AChE, BChE, MAO and TBARS in a dose‐dependent manner. However, Horseradish seeds extract had higher AChE, BChE and MAO inhibitory abilities with IC50 values of 0.27, 0.18 and 0.14 mg/mL, respectively, relatively to Velvet beans (AChE = 0.39; BChE = 0.39; MAO = 0.29 mg/mL) extract but displayed lower TBARS inhibitory ability. These biological properties of the seeds explain possible mechanisms for their neuroprotective abilities. However, Horseradish seeds showed better promising potentials than Velvet beans seeds. Practical Application Edible seeds are well known for their various health benefits due to their bioactivity. The findings from this study will add valuable preliminary information regarding the potential use of Velvet beans seeds and Horseradish seeds as cheap, natural, alternative and/or complementary sources of antioxidative and neuroprotective agents. The findings will provide scientific evidence on health advantages of these seeds that might result from their consumption; thereby enabling consumers and patients with neurodegeneration to make better choices.

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Section: Discussionmentioning

confidence: 97%

“…) but more potent than that from the seeds of avocado pear (Oboh et al . ) on their ChEs inhibitory properties.…”

Section: Discussionmentioning

confidence: 99%

Cognitive Enhancing and Antioxidative Potentials of Velvet Beans (Mucuna pruriens) and Horseradish (Moringa oleifera) Seeds Extracts: A Comparative Study

Adefegha

Oboh

Oyeleye

et al. 2016

Journal of Food Biochemistry

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“…The anticholinesterases and antioxidant activities of P. americana leaf and seed aqueous extracts were investigated via the activities of acetylcholinesterase and butyrylcholinesterase enzymes which are linked with Alzheimer disease, and DPPH, hydroxyl and nitric oxide scavenging ability, respectively. The leaf extract showed the highest phenolic content and radical scavenging activity (Oboh et al , ). Different phytoconstituents of the leaves of P. americana were isolated, and their antioxidant activity were evaluated using DPPH and H 2 O 2 assays.…”

Section: Antioxidant Activitymentioning

confidence: 99%

Effects of Avocado (Persea americana)on Metabolic Syndrome: A Comprehensive Systematic Review

2017

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Metabolic syndrome (MetS) is a clustering of risk factors including high blood glucose, dyslipidemia, hypertension, and obesity that lead to the increased risk of type 2 diabetes mellitus and cardiovascular diseases (CVDs), which are among leading causes of death in the world. Metabolic syndrome increases the risk of type 2 diabetes mellitus and CVDs by approximately five and three folds, respectively. Therefore, it is of vital importance to manage such conditions with herbal options which have less undesirable adverse effects and may be more efficacious in comparison with synthetic options. Avocado is a well-known source of carotenoids, minerals, phenolics, vitamins, and fatty acids. The lipid-lowering, antihypertensive, antidiabetic, anti-obesity, antithrombotic, antiatherosclerotic, and cardioprotective effects of avocado have been demonstrated in several studies. In this review, we aimed to find out avocado's pharmacological effects on different components of MetS. Moreover, this review report is performed on the MetS effects of peel, seed, flesh, and leaves of avocado. Copyright © 2017 John Wiley & Sons, Ltd.

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“…Also, avocado leaves contain persin which is a toxin for lactating livestock [16]. In vitro activity studies such as anticancer, anticholinesterase, antimicrobial, antioxidant, antityrosinase have been performed on the leaves [11,14,[17][18][19][20][21][22][23]. P. americana leaf has exhibited pharmacological activities such as analgesic, anti-inflammatory, anticonvulsant, antihyperlipidemic, hypocholesterolemic, hypoglycemic, hypotensive properties [24][25][26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Avocado (Persea americana Mill.) Leaves in Terms of Public Health

Kendir¹,

Köroğlu²

2018

jrp

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Persea americana Mill. (Lauraceae) originated in Central and Southern of South America, is an evergreen tree. The tree is commonly known as avocado. Avocado is cultivated in all tropical and subtropical regions in the world. This tree has been usually grown in the southern coastal region of Turkey due to its commercial importance. Its fruit is a drupe which consumed as food. Except this, the leaves are widely used for pass kidney stone and against the urinary tract infections as therapeutic among the people in Turkey and Cyprus.The present study, 13 different samples from 5 diverse cities (Ankara, Hatay, İstanbul, Kayseri and Aydın) were purchased. The sample to be used as standard was obtained from the culture form (Dörtyol, Hatay). The morphological properties of leaves, which are part of the plant used as a drug, were determined both in the standard sample and in the purchased samples. Anatomical features of cross and surface sections from standard avocado leaves with cross sections from the petiole of natural avocado leaves were investigated and determined. Besides, the distinctive anatomical structures of the powdered samples (standard sample and samples purchased from the market) were demonstrated. The avocado leaf is bifacial. The hairs are only located the lower surface of the leaf and mostly unicellular. Secretory cells and crytals were observed in the avocado leaf and petiole. Crystals are simple in various sizes and small raphids. The stomata confined to the lower surface and anomocytic type (3-6 subsidiary cells). In cross section taken from the petiole, the hairs were observed to be gathered on the upper surface of the petiole.

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Aqueous extracts of avocado pear (Persea americana Mill.) leaves and seeds exhibit anti-cholinesterases and antioxidant activities in vitro

Cited by 66 publications

References 41 publications

Cognitive Enhancing and Antioxidative Potentials of Velvet Beans (Mucuna pruriens) and Horseradish (Moringa oleifera) Seeds Extracts: A Comparative Study

Cognitive Enhancing and Antioxidative Potentials of Velvet Beans (Mucuna pruriens) and Horseradish (Moringa oleifera) Seeds Extracts: A Comparative Study

Effects of Avocado (Persea americana)on Metabolic Syndrome: A Comprehensive Systematic Review

Evaluation of Avocado (Persea americana Mill.) Leaves in Terms of Public Health

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