Aqueous extracts from Menyanthes trifoliate and Achillea millefolium affect maturation of human dendritic cells and their activation of allogeneic CD4+ T cells in vitro

Jonsdottir, Gudbjorg; Ómarsdóttir, Sesselja; Vikingsson, Arnor; Harðardóttir, Ingibjörg; Freysdóttir, Jona

doi:10.1016/j.jep.2011.04.006

Cited by 16 publications

(11 citation statements)

References 26 publications

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“…Apart from being rich in LC n-3 PUFAs, cod liver oil is also naturally rich in vitamin D3. As previously described, 31,62 studies have found that vitamin D3 can promote tolerogenic dendritic cells, e.g. by down-regulating CD86 and IL-12, but without affecting IL-10 secretion, thus preventing inflammation.…”

Section: Immunomodulation Of Dendritic Cellsmentioning

confidence: 57%

“…Monocyte-derived dendritic cells, obtained as previously described, 31 were matured with IL-1 at 10 ng mL −1 and tumour necrosis factor alpha (TNF-) at 50 ng mL −1 (both from R&D Systems, Abingdon, UK) and stimulated with lipopolysaccharides (Sigma, St. Louis, MO, USA) for 2 days. At the same time the dendritic cells were treated with freeze-dried digests at 1, 10 and 100 μg DW mL −1 (equivalent to 0.015, 0.15 and 1.5 μL non-dried digest mL −1 ) diluted in 0.002% dimethyl sulfoxide (DMSO) or 0.002% DMSO alone as the solvent control.…”

Section: Determination Of Immunomodulation Using Monocyte-derived Denmentioning

confidence: 99%

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Effect ofin vitrodigested cod liver oil of different quality on oxidative, proteomic and inflammatory responses in the yeastSaccharomyces cerevisiaeand human monocyte-derived dendritic cells

Larsson

Istenič

Wulff

et al. 2015

J. Sci. Food Agric.

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Section: Immunomodulation Of Dendritic Cellsmentioning

confidence: 57%

Section: Determination Of Immunomodulation Using Monocyte-derived Denmentioning

confidence: 99%

Effect ofin vitrodigested cod liver oil of different quality on oxidative, proteomic and inflammatory responses in the yeastSaccharomyces cerevisiaeand human monocyte-derived dendritic cells

Larsson

Istenič

Wulff

et al. 2015

J. Sci. Food Agric.

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“…It is widely used in folk medicine (Wichtl, 1997). In Europe, it has been used as a remedy to treat digestive problems, diabetes, hepatobiliary diseases, amenorrhea, and also consumed for its antitumor and anti-inflammatory properties (Baretta et al, 2012;Cavalcanti et al, 2006;Jonsdottir, Omarsdottird, Vikingssona, Hardardottirc, Freysdottir, 2011). In addition, antimicrobial and antioxidant properties of yarrow have also been reported (Candan et al, 2003;Potrich et al, 2010;Trumbeckaite et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Encapsulation of yarrow essential oil in hydroxypropyl-beta-cyclodextrin: physiochemical characterization and evaluation of bio-efficacies

Rakmai

Cheirsilp

Agrasar

et al. 2017

CyTA - Journal of Food

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Essential oil from yarrow (Achillea millefolium L. s. l.) has a broad spectrum of pharmacological activities. However, active chemical components of yarrow oil are sensitive to environmental factors such as, light, oxygen and temperature. Encapsulation of essential oil offers solutions for the limitation. Yarrow oil was encapsulated in hydroxypropyl-β-cyclodextrin (HPβCD) through freezedrying technique with encapsulation efficiency of 45%. Inclusion complex formation was examined by scanning electron microscope, Fourier transformed infrared spectroscopy and UV-vis analysis and phase solubility study. Yarrow oil gave strong antioxidant activity of 72% DPPH scavenging at 50 μg/mL. HPβCD could protect active compounds of essential oil and retained antioxidant activity after sunlight exposure. Yarrow oil also exhibited antibacterial activity against Staphylococcus aureus and Escherichia coli with the minimum inhibitory concentration (MIC) values of 250 μg/mL and 500 μg/mL, respectively. The antibacterial efficacy was much improved after encapsulation against both S. aureus and E. coli with the MIC value of 62.5 μg/mL.Encapsulación de aceite esencial de milenrama en hidroxipropil-beta-ciclodextrina. Caracterización fisicoquímica y evaluación de bioeficiencia. RESUMENEl aceite esencial de la milenrama (Achillea millefolium L. s. l.) presenta un amplio espectro de actividades farmacológicas. Sin embargo, los componentes químicos activos del aceite son sensibles a factores ambientales tales como, luz, oxígeno y temperatura. La encapsulación del aceite esencial ofrece soluciones para esta limitación. El aceite se encapsuló en hidroxipropil-β-ciclodextrina (HPβCD) mediante la técnica de liofilización con un rendimiento del 45%. La formación del complejo de inclusión se analizó mediante técnicas de SEM, FT-IR y UV-vis y se realizó un estudio de solubilidad. El aceite presentó una fuerte actividad antioxidante de 72% de DPPH. HPβCD protege los compuestos activos de aceite esencial y retoene la actividad antioxidante después de la exposición a luz solar. El aceite también exhibió actividad antibacteriana contra Staphylococcus aureus y Escherichia coli con valores mínimos de concentración inhibitoria (MIC) de 250 μg/mL y 500 μg/mL, respectivamente. La eficacia antibacteriana mejoró mucho después de la encapsulación contra S. aureus y E. coli con un valor de CIM de 62,5 μg /ml. ARTICLE HISTORY

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“…Achillea millefolium plants have been used for centuries for treat spasms, digestive complaints, menstruation disorders, urinary infections, anti inflammatory, spasmolytic, hemostatic, diarrhea, abdominal pain, stomach ache and other ailments 4 . Also it has been reported Achillea millefolium plants have some pharmacological effects such as antispasmodic, antimicrobial, analgesic, antipyretic, choleretic, cytotoxic, and estrogenic 5 .…”

Section: Introductionmentioning

confidence: 99%

Radiolabeling of methanol extracts of yarrow (Achillea millefolium l) in rats

Cekic

Kılçar²,

Müftüler

et al. 2012

Acta Cir. Bras.

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PURPOSE: Current study is focused on extraction with methanol, purification, labeling with 131 I using iodogen method of the yarrow plant and investigating in vivo biological activity using biodistribution and imaging studies on healthy animal models. The aim of the study is to contribute plant extracts to discover new drugs in the diagnosis and treatment of several diseases. METHODS: Nine female and nine male healthy Wistar albino rats, which were approximately 100-150 g in weight, were used for biodistribution studies. For imaging studies four healthy male Balb-C mice were used. Quality control studies were done utilizing thin layer radio chromatography (TLRC) and high performance liquid chromatography (HPLC) methods. For biodistribution studies, 131 I radiolabeled Peak 7 ( 131 I-Peak 7) was sterilized and injected into the tail veil of rats and imaging studies were obtained using Kodak FX PRO in vivo Imaging System. RESULTS: The radiolabeling yield of each purified the bioactive extracts of the yarrow plant, seven peaks was between 79 and 92%. The highest radiolabeling yield was calculated for 131 I radiolabeled seventh peak ( 131 I-Peak 7) (92.78±5.04, n=5). For this reason the biodistribution and imaging studies were done for 131 I-Peak 7. That's why; these studies with Peak 7 were carried out. CONCLUSION: Peak 7 was radiolabeled with 131 I in high yield for using imaging and therapeutic studies in nuclear medical applications. Key words: Achillea. Luteolin. Iodine Isotopes. Chromatography, Liquid. Diagnostic Imaging. Rats. RESUMO OBJETIVO:O atual estudo tem por objetivo a extração com metanol, purificação, marcação com I 131 usando o método direto de marcação da planta Achillea, para investigar in vivo a atividade biológica usando biodistribuição e estudos de imagem em modelos animais saudáveis. O objetivo do estudo é contribuir com extratos de plantas para descobrir novas drogas para o diagnóstico e tratamento de várias doenças. MÉTODOS: Nove fêmeas e nove machos ratos Wistar albino saudáveis, com aproximadamente 100 a 150g de peso foram usados para estudos de biodistribuição. Para estudos de imagem, quatro camundongos Balb-C machos e saudáveis foram usados. Estudos de controle de qualidade foram realizados usando métodos de cromatografia de camada fina e cromatografia líquida de alta performance. Para estudos de biodistribuição, pico 5 radiografado com I 131 (I 131 -Peak 7) foi esterilizado e injetado na veia da cauda dos ratos e estudos de imagem foram obtidos usando Sistema de Imagem Kodak FX PRO in vivo. RESULTADOS: O retorno radiomarcado de cada extrato bioativo purificado da planta Achillea sete picos estavam entre 79 e 92%. O retorno com maior marcação foi calculado para I 131 sétimo pico (I 131 -Peak 7) (92,78±5,04, n=5). Por esta razão os estudos de biodistribuição e de imagem foram feitos para I 131 -Peak 7. CONCLUSÃO: Peak 7 foi radiomarcado com I 131 em alto retorno para uso em estudos terapêuticos e de imagens nas aplicações médicas nucleares. Descritores: Achillea. Luteolina. Isótop...

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Aqueous extracts from Menyanthes trifoliate and Achillea millefolium affect maturation of human dendritic cells and their activation of allogeneic CD4+ T cells in vitro

Cited by 16 publications

References 26 publications

Effect ofin vitrodigested cod liver oil of different quality on oxidative, proteomic and inflammatory responses in the yeastSaccharomyces cerevisiaeand human monocyte-derived dendritic cells

Effect ofin vitrodigested cod liver oil of different quality on oxidative, proteomic and inflammatory responses in the yeastSaccharomyces cerevisiaeand human monocyte-derived dendritic cells

Encapsulation of yarrow essential oil in hydroxypropyl-beta-cyclodextrin: physiochemical characterization and evaluation of bio-efficacies

Radiolabeling of methanol extracts of yarrow (Achillea millefolium l) in rats

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