Aqueous extract of the medicinal plant Mentha crispa alters the biodistribution of the radiopharmaceutical sodium pertechnetate in Wistar rats

Abstract

Mentha crispa extract or 0.9% NaCl were (15 days) administered daily by gavage to Wistar rats. Animals then received Na 99m TcO 4 via ocular plexus and were sacrificed. Organs were isolated, radioactivity was determined, percentages of radioactivity in each organ was calculated, and statistical analyses performed. Significant (p = 0.0061) increases of radioactivity were observed in kidney, spleen, and thyroid, which could be exampled by the effects of the extract and/or by the generation of active metabolites.

Effects of broccoli extract on biodistribution and labeling blood components with 99mTc-GH

“…There are many studies about effects of herbal extracts on biodistribution of radiopharmaceuticals 7,13,15 . One of them is about the effect of the P. flavicarpa extract on the biodistribution of sodium 99m…”

“…The reason of this alteration was tried to explain that as the radiobiocomplex studied is an ion, the effect of the components of extract would also act in the transport of the pertechnetate ion through the cellular membrane of determined organs In literature, the changes at the biodistribution studies are explained by the presence of specific chemical compounds in the extract or by the generation of active metabolites capable to interfere with the biodistribution of the studied radiobiocomplex 15 .…”

Drug interaction with radiopharmaceuticals: a review

“…Hladik III et al (1987), Hesslewood and Leung (1994) and Sampson (1999) have reported that various synthetic drugs (medications) are capable of altering the bioavailability of different radiobiocomplexes. Moreover, other authors have suggested that medicinal plants (natural drugs) can be also associated with the DIR (Gomes et al, 2002a, Santos-Filho et al, 2004a, Moreno et al, 2004. Vincristine is a chemotherapeutic drug used in several protocols in oncology and (i) in an animal model, this drug has increased significantly the uptake of the radiobiocomplex 99m Tc-DTPA (diethylenetriaminepentaacetic acid) by the thymus, ovary, uterus, spleen, kidneys, heart, stomach, lungs, liver and bone (Britto et al, 1998), (ii) it modified the bioavailability of the 99m Tc-phytate in Balb/c mice (Mattos et al, 1999a), (iii) it decreased the uptake of 99m Tc-MDP (methylenediphosphonic acid) by the uterus, ovary, spleen, thymus, lymph nodes (inguinal and mesentheric), kidney, liver, pancreas, stomach, heart, brain and bone isolated from animals (Mattos et al, 1999b), (iv) it decreased the uptake of 99m Tc-PYP (sodium pyrophosphate) by the spleen, thymus, lymph nodes (inguinal and mesentheric), kidney, lung, liver, pancreas, stomach, heart and brain, and it increased the uptake by the bone and thyroid in the treated animals (Mattos et al, 1999b), (v) it decreased the uptake of the 99m Tc-GHA (glucoheptonic acid) by the uterus, ovary, spleen, thymus, lymph nodes (inguinal and mesentheric), kidney and heart isolated from animals (Mattos et al, 2001), and (vi) it increased the blood pool of the radioactivity of Ga-67 citrate (Hladik III et al, 1987).…”

Evaluation of consequences of the treatment of blood with extracts of Hypericum perforatum and Mentha crispa

“…The main pharmacodynamic effect of mint oil is a dose-related antispasmodic effect on smooth musculature due to interference of menthol with movement of calcium across the cell membrane, relevant to the gastrointestinal tract (Grigoleit and Grigoleit, 2005). We have reported that an extract of mint can alter biodistribution of radiopharmaceutical sodium pertechnetate in kidney, spleen, and thyroid of Wistar rats, and this result could be justified by effects of the extract and/or by generation of active metabolites (Santos-Filho et al, 2008).…”