Aqueous Extract of <i>Oldenlandia diffusa</i> Suppresses LPS-Induced iNOS, COX-2 and TNF-α Expression in RAW 264.7 Cells via the NF-κB Activity

Abstract

Purpose: To elucidate the anti-inflammatory mechanisms of aqueous extract of Oldenlandia diffusa (AEOD) in cells. LPS-induced mRNA and protein expression of iNOS, COX-2 and TNF-α were attenuated by treatment with AEOD. These data imply that AEOD tightly regulates the expression of these inflammatory mediators at the transcriptional level. Therefore, we determined the effects of AEOD on nuclear factor-κB (NF-κB) activity, which has been considered to be a potential transcriptional factor for regulating the expression of iNOS, COX-2 and TNF-α. As expected, AEOD suppressed the LPS-induced degradation and phosphorylation of

Allicin Protects against Lipopolysaccharide-Induced Acute Lung Injury by Up-Regulation of Claudin-4

“…Among them, TNF-α and IL-6 were considered as the most important inflammatory mediators in innate immune response [11]. Transforming growth factor β (TGF-β) has been shown to play an anti-inflammatory role in immunity and autoimmunity [12].…”

Usage of <em>Oldenlandia diffusa</em> for skin diseases and skin-care

“…Oldenlandia diffusa also suppressed the LPS-induced DNA binding activity of NF-κB to induce the production of NO, PGE2, and TNF-α by regulating the activation of NF-κB. 7 Deng et al reported the use of Oldenlandia diffusa in phytotherapy for the management of psoriasis. Phytotherapy (PT) interventions included oral administration of single or multiple PTs or extracts thereof.…”