Aqueous extract of Lespedeza cuneata improves male menopause by increase of nitric oxide and dihydrotestosterone

Rhee, Yun-Hee; Yoo, Sang-Woo; Lee, Seong; Chung, Phil‐Sang

doi:10.1007/s10068-018-0434-x

Cited by 2 publications

(1 citation statement)

References 41 publications

(49 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has long been used to treat cough and asthma, low vitality, and premature ejaculation. In particular, L. cuneata has been shown to enhance vasodilation, the activity of dihydrotestosterone (DHT) and 17-β-hydroxysteroid dehydrogenases (17β-HSD), testosterone production [17][18][19][20]. This study has been planned to evaluate the effects of AESL on rat blood testosterone, muscle mass, and sperm count.…”

Section: Introductionmentioning

confidence: 99%

Sericea lespedeza (Lespedeza cuneata) whole plant extract enhances rat muscle mass and sperm production by increasing the activity of NO-cGMP pathway and serum testosterone

Mo¹,

Kim²,

Choi³

et al. 2021

Trop. J. Pharm Res

Self Cite

View full text Add to dashboard Cite

Purpose: To analyze the effects of an aqueous extract of Sericea lespedeza (SL) on rat male menopause.Methods: Levels of nitric oxide (NO), endothelial nitric oxide synthase (NOS), cGMP, and prostaglandin E2 (PGE2) in the penile corpus cavernosum of the rats were evaluated using appropriate kits. Serum levels of dihydrotestosterone (DHT), testosterone, sex hormone-binding globulin (SHBG), and 17-beta hydroxysteroid dehydrogenases (17β-HSD) were measured with enzyme-linked immunosorbent assay kits. Total and motile sperms were counted on a hemocytometer. Histological changes in rat testis and epididymis were analyzed with hematoxylin and eosin staining.Results: The levels of NO, NOS, and cGMP (but not PGE2) increased in a dose-dependent manner (p< 0.05) upon administration of an aqueous extract of SL (AESL), while levels of DHT, 17β-HSD, and testosterone increased in the group administered with 300 mg/kg of AESL. Epididymal sperm count increased by 24 % in such rats compared to controls (p < 0.05).Conclusion: The aqueous extract of SL improves sperm count and muscle mass in rats by increasing the levels of NO, NOS, cGMP and testosterone. Thus, SL extract can potentially be developed as an alternative therapeutic agent for clinical management of TDS. Keywords: NO-cGMP, Testosterone, Hormones, Sperm count, Muscle mass, Sericea lespedeza, Lespedeza cuneata

show abstract

Section: Introductionmentioning

confidence: 99%

Sericea lespedeza (Lespedeza cuneata) whole plant extract enhances rat muscle mass and sperm production by increasing the activity of NO-cGMP pathway and serum testosterone

Mo¹,

Kim²,

Choi³

et al. 2021

Trop. J. Pharm Res

Self Cite

View full text Add to dashboard Cite

show abstract

Study of the Amino Acid Composition of the Bi-Color Lespedesia Growing in the Krasnodar Region

M.R.,

T.E.

2023

Mediko-farmacevtičeskij žurnal "Pulʹs"

View full text Add to dashboard Cite

As is known, biologically active compounds in plants are in complexes easily absorbed by the human body and in biologically available concentrations, therefore they have a higher phar-macological activity compared to synthetic analogues. Plants synthesize all the amino acids necessary to build protein molecules. The ability of plant amino acids to participate in the as-similation of other biologically active substances by the body, as well as a wide range of their biochemical, and as a result, pharmacological action, attracts more and more attention of re-searchers and the study of the composition and content of amino acids in medicinal plant raw materials as potential sources of drugs. That is why the study of the qualitative and quantita-tive content of amino acids in medicinal plant raw materials and in preparations derived from it is of great practical importance and of a certain scientific interest. The experience of using shoots of Lespedeza bicolor in official and folk medicine tes-tifies to its wide therapeutic possibilities, which served as the basis for research to clarify its chemical composition in relation to amino acids. This paper presents data on the qualitative and quantitative amino acid composition of the aerial organs of Lespedeza bicolor (Lespedeza bicolor L, plant family Fabaceae) growing in the Krasnodar Territory. A comparative study of the main essential and non-essential amino acids in flowers, leaves and shoots of Lespede-za bicolor was carried out by capillary electrophoresis. It has been established that the flowers and leaves of Lespedeza bicolor contain 11 amino acids each, the dominant amino acid of both flowers and leaves is proline; Lespedeza bicolor shoots contain 12 amino acids, 6 of which are essential (threonine, valine, methionine, leucine, phenylalanine, lysine). Leucine is present only in the leaves, and cysteine only in the flowers of the studied plant

show abstract

Aqueous extract of Lespedeza cuneata improves male menopause by increase of nitric oxide and dihydrotestosterone

Cited by 2 publications

References 41 publications

Sericea lespedeza (Lespedeza cuneata) whole plant extract enhances rat muscle mass and sperm production by increasing the activity of NO-cGMP pathway and serum testosterone

Sericea lespedeza (Lespedeza cuneata) whole plant extract enhances rat muscle mass and sperm production by increasing the activity of NO-cGMP pathway and serum testosterone

Study of the Amino Acid Composition of the Bi-Color Lespedesia Growing in the Krasnodar Region

Contact Info

Product

Resources

About