Aqueous extract of <i>Hibiscus sabdariffa</i> L. decelerates acetaminophen‐induced acute liver damage by reducing cell death and oxidative stress in mouse experimental models

Liu, Liang‐Chih; Wang, Chau‐Jong; Lee, Ching‐Chih; Su, Sheng-Chi; Chen, Huei-Lin; Hsu, Jane Lu; Lee, Huei-Jane

doi:10.1002/jsfa.3821

Cited by 42 publications

(22 citation statements)

References 102 publications

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“…These ameliorative effects of H. sabdariffa extract may be mediated by inhibition of hepatic stellate cell activation. In accord with the preventive effects of H. sabdariffa extract’s components during the development of chemically induced hepatic damage [20, 21, 43, 49] the present study shows that H. sabdariffa extract is effective in the amelioration of STZ-induced liver fibrosis, which would confer a highly significant therapeutic advantage. Hibiscus sabdariffa extract is a composite of several antioxidants, such as protocatechuic acid [20, 50] and anthocyanins [21, 22] which prevents peroxidative liver damage.…”

Section: Discussionsupporting

confidence: 79%

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Anti-hepatotoxic activities of Hibiscus sabdariffa L. in animal model of streptozotocin diabetes-induced liver damage

Adeyemi

Ukwenya

Obuotor

et al. 2014

BMC Complement Altern Med

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BackgroundFlavonoid-rich aqueous fraction of methanolic extract of Hibiscus sabdariffa calyx was evaluated for its anti-hepatotoxic activities in streptozotocin-induced diabetic Wistar rats.MethodsDiabetes Mellitus was induced in Wistar rats by a single i.p injection of 80 mg/kg b.w. streptozotocin (STZ) dissolved in 0.1 M citrate buffer (pH 6.3).ResultsThe ameliorative effects of the extract on STZ-diabetes induced liver damage was evident from the histopathological analysis and the biochemical parameters evaluated in the serum and liver homogenates. Reduced levels of glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) (3.76 ± 0.38 μM, 0.42 ± 0.04 U/L, 41.08 ± 3.04 U/ml, 0.82 ± 0.04 U/L respectively) in the liver of diabetic rats were restored to a near normal level in the Hibiscus sabdariffa -treated rats (6.87 ± 0.51 μM, 0.72 ± 0.06 U/L, 87.92 ± 5.26 U/ml, 1.37 ± 0.06 U/L respectively). Elevated levels of aspartate amino transferase (AST), alanine amino transferase (ALT) and alkaline phosphatase (ALP) in the serum of diabetic rats were also restored in Hibiscus sabdariffa -treated rats. Examination of stained liver sections revealed hepatic fibrosis and excessive glycogen deposition in the diabetic rats. These pathological changes were ameliorated in the extract-treated rats.ConclusionThe anti-hepatotoxic activity of Hibiscus sabdariffa extract in STZ diabetic rats could be partly related to its antioxidant activity and the presence of flavonnoids.

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Section: Discussionsupporting

confidence: 79%

“…This potent antioxidation is thought to form the basis of many of the other healing activities of HSCE including its hepatoprotective activities. Compounds proven to have this antioxidant activity include anthocyanins and protocatechuic acid [43]. …”

Section: Discussionmentioning

confidence: 99%

Anti-hepatotoxic activities of Hibiscus sabdariffa L. in animal model of streptozotocin diabetes-induced liver damage

Adeyemi

Ukwenya

Obuotor

et al. 2014

BMC Complement Altern Med

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“…17) Our previous investigation has also indicated that a water extract of Hibiscus sabdariffa L. could protect individuals from acetaminophen-induced liver injury by reducing oxidative stress. 18) We have shown in this study the functional components in Hibiscus sabdariffa L., and propose that HPE might be the major contributor to improving the oxidative status in AAP-induced liver damage. We have also previously demonstrated that HPE could inhibit lipopolysaccharide-induced inflammation by improving the antioxidative conditions and decelerating the inflammatory responses.…”

Section: Discussionmentioning

confidence: 57%

A Polyphenol Extract ofHibiscus sabdariffaL. Ameliorates Acetaminophen-Induced Hepatic Steatosis by Attenuating the Mitochondrial Dysfunctionin Vivoandin Vitro

Lee¹,

Kuo²,

Wang³

et al. 2012

Bioscience, Biotechnology, and Biochemistry

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Oxidative stress is the major contributor to acetaminophen (AAP)-caused liver damage. It promotes mitochondrial oxidative stress and collapses the mitochondrial membrane potential to cause cell death. We have previously shown that a polyphenol extract of Hibiscus sabdariffa L. (HPE) potentiated the antioxidative effect. We further examined in this study the possible mechanism of HPE against AAP-caused liver damage. BABL/c mice were orally fed with HPE (100, 200 or 300 mg/kg) for two weeks prior to an i.p. injection of 1000 mg/kg of AAP. The mice were decapitated 6 h after the AAP injection to collect the blood and liver for further determination. The results show that pretreating with HPE increased the level of glutathione (GSH), decreased the level of lipid peroxidation, and increased catalase activity in the liver. A histopathological evaluation shows that HPE could decrease AAP-induced liver sterosis accompanied by a decreased expression of AIF, Bax, Bid, and p-JNK in the liver. An in vitro assay revealed that HPE could reduce AAP-induced death of BABL/c normal liver cells (BNLs), reverse the lost mitochondrial potency and improve the antioxidative status, similarly to the results of the in vivo assay. We show in this study that HPE possessed the ability to protect the liver from AAP-caused injury. The protective mechanism might be regulated by decreasing oxidative stress and attenuating the mitochondrial dysfunction.

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“…Total phenolic compounds were determined with the Folin-Ciocalteu reagent and expressed as mg gallic acid equivalent per 100 g fresh BB. 24 The total flavonoid levels were measured with aluminum chloride colorimetric method. The results are presented as mg quercetin equivalents per 100 g fresh BB.…”

Section: Total Phenolic and Total Flavonoid Assay In Fresh Bbmentioning

confidence: 99%

Blueberry treatment attenuates D‐galactose‐induced oxidative stress and tissue damage in rat liver

Çoban

Betül-Kalaz

Küçükgergin

et al. 2013

Geriatrics Gerontology Int

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Aqueous extract of Hibiscus sabdariffa L. decelerates acetaminophen‐induced acute liver damage by reducing cell death and oxidative stress in mouse experimental models

Abstract: It has been demonstrated that HSE can protect the mouse liver from AAP-induced injury and that the protective mechanism might involve decreasing oxidative stress and reducing cell death.

Cited by 42 publications

References 102 publications

Anti-hepatotoxic activities of Hibiscus sabdariffa L. in animal model of streptozotocin diabetes-induced liver damage

Anti-hepatotoxic activities of Hibiscus sabdariffa L. in animal model of streptozotocin diabetes-induced liver damage

A Polyphenol Extract ofHibiscus sabdariffaL. Ameliorates Acetaminophen-Induced Hepatic Steatosis by Attenuating the Mitochondrial Dysfunctionin Vivoandin Vitro

Blueberry treatment attenuates D‐galactose‐induced oxidative stress and tissue damage in rat liver

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