Aqueous Extract of Dacryodes edulis (Burseraceae) Leaves Inhibited Tumor Growth in Female Wistar Rats with 7,12-Dimethylbenz[a]anthracene-Induced Breast Cancer

Mvondo, Marie Alfrede; Kamgaing, Marius Trésor Wego; Ngnokam, Sylvie Lea Wansi

doi:10.1155/2021/9960950

Cited by 7 publications

(4 citation statements)

References 47 publications

(81 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Oestrogens can lead to an increase in ROS, potentially causing oxidative damage. 37 In line with the findings of Mvondo et al 37 this study also observed an increase in mammary gland estradiol levels in female rats after exposure to DMBA. The presence of breast tumours leads to an elevation in estradiol levels, which can be attributed to the invasion of cancer cells and the growth of lobules.…”

Section: Resultssupporting

confidence: 90%

See 1 more Smart Citation

Anticancer Activity of Ethyl Acetate Fraction and Ethanol Leaf Extract of Olax subscorpioidea against DMBA-Induced Female Rats

2024

TJNPR

View full text Add to dashboard Cite

Oxidative stress can cause cell damage, trigger inflammation, and contribute to the development of cancer. 6 There is evidence suggesting that exposure to environmental pollutants, such as PAHs, can potentially elevate the risk of breast cancer. This is thought to occur through mechanisms involving oxidative stress and the activation of oestrogen receptors. 7 7, 12-Dimethylbenz(α)anthracene (DMBA), a polycyclic aromatic hydrocarbon, is commonly employed to induce breast cancer in rats. The DNA is damaged by DMBA-3,4-diol-1,2epoxide through the addition of adenine and guanine residues because of liver and breast tissue metabolism. 8 Breast cancer can be treated through various methods, such as targeted therapy, surgery, chemotherapy, radiation, and hormone therapy. These medicines come with challenges such as resistance, recurrence, high cost, toxicity, and adverse effects. It is crucial to identify alternative or complementary therapies that offer improved efficacy, safety, and cost-effectiveness. 9 Medicinal plant alkaloids, flavonoids, terpenoids, phenolics, and saponins exhibit a variety of biological effects. Some examples are anticancer, antioxidant, anti-inflammatory, and immunomodulatory. 10 There is a significant body of research supporting the preventive effects of medicinal herbs and their derivatives on breast cancer. 11 A recent study highlights the significant impact of curcumin, a phenolic component of turmeric (Curcuma longa), on inhibiting breast cancer cell invasion, metastasis, and proliferation. It achieves this by modulating key signalling pathways such as NF-κB, PI3K/Akt, MAPK, and nt/β-catenin. 12 Vinblastine and vincristine are alkaloids found from the Madagascar periwinkle (Catharanthus roseus). They disrupt the movement of microtubules, which stops cells from growing and killing themselves. These properties make them highly effective chemotherapies for breast cancer. 13 There are several Nigerian medicinal plants that have been found to treat various diseases,

show abstract

Section: Resultssupporting

confidence: 90%

“…Cell development is dependent on the presence of estrogens. 37 cancer prognosis. This marker is highly indicative of patient disease progression, regression, or stability.…”

Section: Resultsmentioning

confidence: 99%

Anticancer Activity of Ethyl Acetate Fraction and Ethanol Leaf Extract of Olax subscorpioidea against DMBA-Induced Female Rats

2024

TJNPR

View full text Add to dashboard Cite

show abstract

“…Dacryodes edulis (Safou) is known for its dietary properties via its edible fruit; its curative and suppressive properties on a mouse model infected with Plasmodium berghei were demonstrated by maximum inhibition of Plasmodium at 57% and chemosuppression of the parasite at 71% [ 66 ]. In addition, this plant has antioxidant [ 67 ], anticancer [ 68 ], antidiabetic [ 69 ] properties that make it a good research model for its multiple effects. The limitation of this review is that it does not allow to conclude on the effect of these molecules on artemisinin-resistant strains which for several years has been considered as a first-line drug instead of chloroquine.…”

Section: Discussionmentioning

confidence: 99%

The Antiplasmodial Potential of Medicinal Plants Used in the Cameroonian Pharmacopoeia: An Updated Systematic Review and Meta-Analysis

Tepa

Ambassa

Ayong

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Malaria is a real public health problem. It is the leading cause of morbidity and mortality in the world. Research in herbal medicine has so far shown that the use of plants against malaria is not to be neglected. This review aims to highlight the antiplasmodial potential of Cameroonian plants. In order to achieve this objective, we conducted a bibliographic search in April 2022 using the PubMed search engine. This research included both the published and unpublished studies. A narrative approach was used to describe the antiplasmodial potential of the various species of plants investigated. Quantitative data were analyzed using R studio 4.1.1 software and random effects model was used to estimate the effect size. The research of the antiplasmodial activity of Cameroonian plants dates back to 2000. This area of research has since provided extensive data to indicate the antiplasmodial potential of several plants, most of which originate from the central region. Despite the heterogeneity observed between the different plant families studied in Cameroon for their in vitro antiplasmodial effect, there is strong evidence that 17 active compounds from these plants would be ideal candidates for the synthesis of new antimalarial drugs. The Dacryodes edulis species could be considered as the best natural alternative in the treatment of uncomplicated malaria according to its properties. It is clear that the traditional Cameroonian pharmacopoeia has many species that contain compounds with antiplasmodial activity. More studies need to be conducted to explore the multitude of unexplored plants that are used in traditional medicine. These studies should take into account the nature of the cell model used for cytotoxicity assessment.

show abstract

“…There have been numerous reports indicating that estrogen receptors are linked to approximately 80% of breast cancers [ 87 ]. Mvondo et al, showed that the aqueous extract of D. edulis leaves reduced the tumor volume in female rats with breast cancer induced by 7,12-dimethylbenz[α]anthracene (DMBA; 50 mg/kg BW) [ 88 ]. In vitro, the cytotoxic potential of D. rostrata peels on breast cancer cell lines was determined using the MTT method.…”

Section: Bioactivity Studiesmentioning

confidence: 99%

The Genus Dacryodes Vahl.: Ethnobotany, Phytochemistry and Biological Activities

Swana,

Tsakem,

Tembu

et al. 2023

Pharmaceuticals

View full text Add to dashboard Cite

Dacryodes Vahl. species, belonging to the Burseraceae family, are widely used in traditional medicine in tropical regions to treat a range of ailments including malaria, wounds, tonsillitis, and ringworms. This review discusses the distribution, ethnobotanical uses, phytochemistry, and bioactivities of Dacryodes species. The intent is to spur future research into isolating and identifying key active principles, secondary metabolites, and crude extracts, and evaluating their pharmacological and toxicological effects, as well as the mechanism of actions to understand their medicinal benefits. A systematic review of scientific electronic databases from 1963 to 2022 including Scifinder, Scopus, Pubmed, Springer Link, ResearchGate, Ethnobotany Research and Applications, Google Scholar, and ScienceDirect was conducted with a focus on Dacryodes edulis (G.Don) H.J. Lam and Dacryodes rostrata (Blume) H.J. Lam. Pharmacological data revealed that D. edulis isolates contain secondary metabolites and other phytochemical groups belonging to the terpenoids class with anti-microbial, anticancer, antidiabetic, antiinflammatory and hepatoprotective activities, highlighting its pharmacological potential in the therapy or management of diverse cancers, cardiovascular, and neurological diseases. Thus, phytochemicals and standardized extracts from D. edulis could offer safer and cost-effective chemopreventive and chemotherapeutic health benefits/regimen, or as alternative therapeutic remedy for several human diseases. Nevertheless, the therapeutic potential of most of the plants in the genus have not been exhaustively explored with regard to phytochemistry and pharmacology, but mostly complementary approaches lacking rigorous, scientific research-based knowledge. Therefore, the therapeutic potentials of the Dacryodes genus remain largely untapped, and comprehensive research is necessary to fully harness their medicinal properties.

show abstract

Aqueous Extract of Dacryodes edulis (Burseraceae) Leaves Inhibited Tumor Growth in Female Wistar Rats with 7,12-Dimethylbenz[a]anthracene-Induced Breast Cancer

Cited by 7 publications

References 47 publications

Anticancer Activity of Ethyl Acetate Fraction and Ethanol Leaf Extract of Olax subscorpioidea against DMBA-Induced Female Rats

Anticancer Activity of Ethyl Acetate Fraction and Ethanol Leaf Extract of Olax subscorpioidea against DMBA-Induced Female Rats

The Antiplasmodial Potential of Medicinal Plants Used in the Cameroonian Pharmacopoeia: An Updated Systematic Review and Meta-Analysis

The Genus Dacryodes Vahl.: Ethnobotany, Phytochemistry and Biological Activities

Contact Info

Product

Resources

About