Aqueous extract of black tea (Camellia sinensis) prevents ethanol+cholecystokinin-induced pancreatitis in a rat model

Das, Dolan; Mukherjee, Sandip; Das, A. S.; Mukherjee, Maitrayee; Mitra, Chandan

doi:10.1016/j.lfs.2005.09.020

Cited by 26 publications

(28 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also, they indicated that exposure of hepatocytes to ethanol alters the membrane structure and functions by increasing the leakage of enzymes into the circulation [18]. On the other hand, some of them reported that, excess alcohol consumption has been linked with altered liver metabolism and liver damage [19]. At reverse, the results obtained by others found a decrease in serum total proteins and albumin in ethanol administered rats [20].…”

Section: Discussionmentioning

confidence: 99%

Protective Activity of Camel’s Milk and Urine Mixture (<i>Camelus dromedaries</i>) against Ethanol-Induced Hepatotoxicity in Rats

Elhag¹,

Bernard²,

Badwi³

2017

ABB

View full text Add to dashboard Cite

This study was implemented at the University of Khartoum to investigate the protective effect of camel milk mixed with camel urine against alcohol-induced liver damage in Wistar albino rats. The reasons for combining camel milk and urine together are because that in Sudan this combination is used extensively in traditional medicine and they claimed that this combination cures a lot of diseases including liver disease and jaundice; 25 Wister Albino rats of both sexes were brought and divided into 5 groups. Group 1 (control group) received normal saline, group 2 received ethanol 10% at dose of (0.5 g/100g body weight) and group 3 rats received Silymarin (5 mg/100g body weight) plus ethanol 10% (0.5 g/100g). Group 4 received a mixture of camel milk and urine (1:1) at the rate of 2 ml/100g and group 5 rats were administered with the mixture of camel's milk and urine as in group 4 plus ethanol 10% (0.5 g/100g). All treatments given by an oral intubation, experiment lasts for 28 days, rats were euthanized, serum samples and liver sections obtained. Oral administration of 10% ethanol (0.5 g/100g) induced liver damage which was clear in group 2 in a form of generalized necrosis, fatty change and congestion, beside high elevation of serum enzymes (AST, ALT, and ALP). Giving camel's milk and urine mixture to group 5 with ethanol 10% (0.5 g/100g), resulted in significant reduction of levels of serum enzymes (AST, ALT, and ALP) and in stabilization of serum metabolites (total protein, albumin and bilirubin). The degree of reduction was lower when significantly compared to (Silymarin + ethanol) group, and all results were verified by the histopathological changes. Hepatoprotective effects of camel's milk and urine mixture were recorded and this could be attributed to antioxidant activity or to its chelate effects on toxicants. Drinking raw camel milk and urine mixture,

show abstract

Section: Discussionmentioning

confidence: 99%

Protective Activity of Camel’s Milk and Urine Mixture (<i>Camelus dromedaries</i>) against Ethanol-Induced Hepatotoxicity in Rats

Elhag¹,

Bernard²,

Badwi³

2017

ABB

View full text Add to dashboard Cite

show abstract

“…GTE has been found to quench reactive oxygen species such as singlet oxygen, superoxide and hydroxyl radicals [14]. The anti-platelet cohesion action of catechin enables the kidney malfunctions resulting from diabetes to return to a normal state [15].…”

Section: Discussionmentioning

confidence: 99%

Effect of Green Tea Extract on Histological Structure of Kidney, Pancreas and Adrenal Gland in Alloxan-Induced DiabeticMale Albino Rats

Al-Hilfy

2013

JNUS

View full text Add to dashboard Cite

Histological structure of kidney, pancreas and adrenal gland in alloxan-induced diabetic rats was investigatedafter daily oral administration of green tea water extract for 4 weeks. Forty adultmale albino rats Rattusnorvegicus, 12 weeks old, weighing 150-160 g were divided into 4 experimental groups: The first group was considered as negative control group. The second groups were affected by inducing experimental diabetes by intraperitonial injection of (150 mg/kg b.w) alloxan. The third group was considered as positive control and treated with water extract of the green tea (200 mg/kg b.w), and the fourth group was affected by inducing diabetes and treated with green teaextract. Kidney, adrenal gland and pancreatic samples were obtained and processed for microscopic evaluation after staining the prepared sections with both Heamatoxylin and Eosin. No histological changes were found in the examined organs belong to rats treated with green tea, (+ve control) while there was a severe histopatholoigical changes like aggregation of inflammatory, neutrophil and monocytes around the blood vessels in kidney tissue, severe fatty degenerative in the adrenal gland and destruction of Island of Langerhans of diabetic rats group. The results showed less extensive histological changes like degeneration of the cells lining the kidney tubules, vaculation of glumerules, and weak fatty degeneration in cellslining of kidney tubules, also moderate fatty degenerative in pancreas tissue and adrenal gland were found in diabetic rat treated with green tea group. From these results it can be conclude that the consumption of green tea extract reduced the degenerative effects of alloxan in histological structures.

show abstract

Section: Antioxidants and Herbal Supplementsmentioning

confidence: 99%

“…76,77 In rats with ethanol-induced and cholecystokinin-induced pancreatitis, feeding with black tea extract allowed for improved amylase and lipase levels with increased anti-inflammatory, antioxidant, and antiapoptotic activity. 76 Polyphenols from green tea were studied in mice with cerulein-induced pancreatitis. 77 The study group observed that intraperitoneal administration of green tea polyphenols caused attenuation of the effect of pancreatitis through modification of inflammatory submit your manuscript | www.dovepress.com and oxidative stress pathways.…”

Section: Antioxidants and Herbal Supplementsmentioning

confidence: 99%

Nutritional advice for prevention of acute pancreatitis: review of current opinion

Lowe¹,

Sevilla²

2012

NDS

View full text Add to dashboard Cite

Pancreatitis is inflammation of the pancreas that can be acute and self-limiting or, in a small percentage of patients, recurrent. Patients with recurrent episodes of acute pancreatitis (RAP) often progress to chronic pancreatitis. Pancreatitis in all forms causes significant economic and social burdens. Prevention of RAP may decrease those burdens and halt progression to chronic disease. Unfortunately, no therapy has proven effective at altering the course of RAP. While enteral nutritional therapy plays an important role in the treatment of acute pancreatitis during episodes, nutritional advice provided to patients in an attempt to prevent recurrent episodes has not proven effective in most cases. Discontinuing alcohol consumption and treating dyslipidemia with diet and medication can help patients with these issues. In patients whose pancreatitis is associated with celiac disease or eosinophilic gastroenteritis, a gluten-free diet and avoidance of food allergens can be effective in stopping RAP. Advice to take pancreatic enzyme replacement therapy, lose weight, control diabetes, decrease dietary sucrose, decrease dietary fat or avoid monosodium glutamate has little to no evidence of efficacy. Some studies suggest that an antioxidant cocktail may decrease the frequency of RAP and the intensity of chronic pain, but the evidence is weak. Nutritional therapy may have a role in the treatment of patients with RAP. At present, there are no clear guidelines for nutritional advice to give these patients. More studies are needed to identify nutritional interventions that will benefit patients with RAP.

show abstract

Aqueous extract of black tea (Camellia sinensis) prevents ethanol+cholecystokinin-induced pancreatitis in a rat model

Cited by 26 publications

References 46 publications

Protective Activity of Camel’s Milk and Urine Mixture (<i>Camelus dromedaries</i>) against Ethanol-Induced Hepatotoxicity in Rats

Protective Activity of Camel’s Milk and Urine Mixture (<i>Camelus dromedaries</i>) against Ethanol-Induced Hepatotoxicity in Rats

Effect of Green Tea Extract on Histological Structure of Kidney, Pancreas and Adrenal Gland in Alloxan-Induced DiabeticMale Albino Rats

Nutritional advice for prevention of acute pancreatitis: review of current opinion

Contact Info

Product

Resources

About

Aqueous extract of black tea (Camellia sinensis) prevents ethanol+cholecystokinin-induced pancreatitis in a rat model

Cited by 26 publications

References 46 publications

Protective Activity of Camel’s Milk and Urine Mixture (&lt;i&gt;Camelus dromedaries&lt;/i&gt;) against Ethanol-Induced Hepatotoxicity in Rats

Protective Activity of Camel’s Milk and Urine Mixture (&lt;i&gt;Camelus dromedaries&lt;/i&gt;) against Ethanol-Induced Hepatotoxicity in Rats

Effect of Green Tea Extract on Histological Structure of Kidney, Pancreas and Adrenal Gland in Alloxan-Induced DiabeticMale Albino Rats

Nutritional advice for prevention of acute pancreatitis: review of current opinion

Contact Info

Product

Resources

About

Protective Activity of Camel’s Milk and Urine Mixture (<i>Camelus dromedaries</i>) against Ethanol-Induced Hepatotoxicity in Rats

Protective Activity of Camel’s Milk and Urine Mixture (<i>Camelus dromedaries</i>) against Ethanol-Induced Hepatotoxicity in Rats