Aqueous extract from pecan nut [Carya illinoinensis (Wangenh) C. Koch] shell show activity against breast cancer cell line MCF-7 and Ehrlich ascites tumor in Balb-C mice

Hilbig, Josiane; Policarpi, Priscila de Britto; Grinevicius, Valdelúcia M.A.S.; Mota, Nádia S.R.S.; Toaldo, Isabela Maia; Luiz, Marilde Terezinha Bordignon; Pedrosa, Rozangela Curi; Block, Jane Mara

doi:10.1016/j.jep.2017.08.012

Cited by 51 publications

(40 citation statements)

References 43 publications

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“…Hydroxycinnamic acid derivatives of mulberry fruits were reported to increase the production of reactive oxygen species production by acting as pro-oxidants and hence killing the cancer cells [159]. Hilbig et al (2017) [160] reported that an aqueous extract from pecan nut (particularly rich in GA, CA and VA) showed clear inhibitory effects against breast cancer cell line MCF-7, as well as against tumor growth in Balb-C mice. Simin et al (2019) [161] provided an overview of the beneficial biological activities of less known wild onions (A. sect.…”

Section: Natural Extracts As Mixtures Of Phenolic Acidsmentioning

confidence: 99%

Phenolic Acids of Plant Origin—A Review on Their Antioxidant Activity In Vitro (O/W Emulsion Systems) Along with Their in Vivo Health Biochemical Properties

Kiokias

Proestos

Oreopoulou

2020

Foods

136

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Nature has generously offered a wide range of herbs (e.g., thyme, oregano, rosemary, sage, mint, basil) rich in many polyphenols and other phenolic compounds with strong antioxidant and biochemical properties. This paper focuses on several natural occurring phenolic acids (caffeic, carnosic, ferulic, gallic, p-coumaric, rosmarinic, vanillic) and first gives an overview of their most common natural plant sources. A summary of the recently reported antioxidant activities of the phenolic acids in o/w emulsions is also provided as an in vitro lipid-based model system. Exploring the interfacial activity of phenolic acids could help to further elucidate their potential health properties against oxidative stress conditions of biological membranes (such as lipoproteins). Finally, this review reports on the latest literature evidence concerning specific biochemical properties of the examined phenolic acids.

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Section: Natural Extracts As Mixtures Of Phenolic Acidsmentioning

confidence: 99%

Phenolic Acids of Plant Origin—A Review on Their Antioxidant Activity In Vitro (O/W Emulsion Systems) Along with Their in Vivo Health Biochemical Properties

Kiokias

Proestos

Oreopoulou

2020

Foods

136

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“…Ethnobotanical uses of pecan by-products include the consumption of infusions made from the leaves or nutshells for the treatment and prevention of diabetes, obesity, hypertension, hypercholesterolemia, cancer, tuberculosis, and other oxidative stress-related diseases (Caxambú et al, 2016;Gad et al, 2007;Hilbig et al, 2018;Trevisan et al, 2014). Several studies have been carried out using pecan by-products, mainly as antimicrobial, antidiabetic and cell protective ( Table 7).…”

Section: Biological Activity Of Pecan By-productsmentioning

confidence: 99%

“…Other biological actions that pecan by-products have demonstrated include anticancer, antidiabetic, antinflammatory, enzyme inhibition and protection against oxidative stress in liver brain and other tissues. Hilbig et al (2018) studied the anticancer activity of aqueous nutshell extracts on a breast cancer cell line (MCF-7) and in Ehrlich ascites carcinoma in Balb-C mice. The extract showed 4.7 times higher cytotoxicity against MCF-7 cells against than non-cancerous cells (3T3 cells); it showed antiproliferative and apoptotic effects as well as cell cycle arrest, decreasing cell viability in a dose-dependent way, while no effect was observed inthe number of necrotic cells.…”

Section: Biological Activity Of Pecan By-productsmentioning

confidence: 99%

Bioactive components and health effects of pecan nuts and their byproducts: a review

́Álvarez-Parrilla¹,

Urrea-López²,

Rosa³

2018

JFB

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Pecan is a North American native tree that produces a stone fruit or kernel, commonly known as pecan nut,which is highly valuable worldwide due to its sensory quality, and health promoting properties derived from the presence of mono- and polyunsaturated fatty acids, tocopherols and monomeric and polymeric polyphenolic compounds. The increase in the demand for pecan nut leads to an increase in by-products such as leaves, cake and principally nutshell, which have high contents of bioactive components, making them interesting raw materials to produce nutraceuticals with health benefits. The phytochemical content of pecan oil and kernel, as well as that of the main pecan by-products is discussed in detail, paying special attention to the presence of individual polyphenols with monomeric and polymeric structures. Finally, studies regarding the biological activity and potential use of pecan oil, kernel and by-products are summarized and discussed.

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“…It is estimated that the concentration of these elements can reach 167 mg/ g gallic acid [4]. In this context, studies have shown that aqueous extracts of pecan shells (rich in acids such as gallic, 4-hydroxybenzoic, vanillic, chlorogenic, caelic and ellagic) have the ability to induce breast cancer cell death and increase breast cancer survival time of patients with certain tumors [18,27]. Also, shell in fresh condition has been used in nutraceutical products against obesity, hypercholesterolemia and as a source for the precaution of metabolic and inflammatory diseases, neurological disorders, gastric ulcers, and cancer [28].…”

Section: Disease Preventionmentioning

confidence: 99%

Potential applications of pecan residual biomasses: a review

2020

Biointerface Res Appl Chem

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Considering a large amount of high potential materials coming from the processes to obtaining pecan nut, there are important future perspectives to enable an increase of using pecan materials. For this, structural support and the development of scientific research are needed to reuse the wastes in an environmentally friendly way. Thus, the aim of this scientific research is to present a detailed literature overview regarding the characterization of pecan waste materials, the main applications and technologies used to add value to these materials. The study is fundamentally based on the scientific literature related to obtaining products from pecan wastes and their application in food-related areas. The lack of sufficient data on the proposed theme requires a properly structured approach to provide a clear perspective on the subject and to highlight the current limitations. It is evident that pecan culture has presented a prosperous context with respect to the world and Brazilian production. The scientific literature presented many studies that employ the approach of using remaining pecan materials. Thus, it is clear the range of fields that apply the residuals for the most diverse purposes, which enables them to add value to pecan coproducts.

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Aqueous extract from pecan nut [Carya illinoinensis (Wangenh) C. Koch] shell show activity against breast cancer cell line MCF-7 and Ehrlich ascites tumor in Balb-C mice

Cited by 51 publications

References 43 publications

Phenolic Acids of Plant Origin—A Review on Their Antioxidant Activity In Vitro (O/W Emulsion Systems) Along with Their in Vivo Health Biochemical Properties

Phenolic Acids of Plant Origin—A Review on Their Antioxidant Activity In Vitro (O/W Emulsion Systems) Along with Their in Vivo Health Biochemical Properties

Bioactive components and health effects of pecan nuts and their byproducts: a review

Potential applications of pecan residual biomasses: a review

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