Aqueous extract from leaf of Artocarpus altilis provides cardio-protection from isoproterenol induced myocardial damage in rats: Negative chronotropic and inotropic effects

Nwokocha, Chukwuemeka R.; Palacios, Javier; Simirgiotis, Mario J.; Thomas, Jemesha; Nwokocha, Magdalene; Young, Lauriann; Thompson, Rory; Cifuentes, Fredi; Paredes, Adrián; Delgoda, Rupika

doi:10.1016/j.jep.2017.03.037

Cited by 32 publications

(22 citation statements)

References 30 publications

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“…The authors observed that myocardial infarction could modify the pharmacokinetic process of GA and thereby determine its potential activity. Similarly, Nwokocha et al [108] concluded that GA can present negative chronotropic and inotropic effects in isoproterenol induced myocardial damage.…”

Section: Gallic Acidmentioning

confidence: 90%

Phenolic Acids of Plant Origin—A Review on Their Antioxidant Activity In Vitro (O/W Emulsion Systems) Along with Their in Vivo Health Biochemical Properties

Kiokias

Proestos

Oreopoulou

2020

Foods

164

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Nature has generously offered a wide range of herbs (e.g., thyme, oregano, rosemary, sage, mint, basil) rich in many polyphenols and other phenolic compounds with strong antioxidant and biochemical properties. This paper focuses on several natural occurring phenolic acids (caffeic, carnosic, ferulic, gallic, p-coumaric, rosmarinic, vanillic) and first gives an overview of their most common natural plant sources. A summary of the recently reported antioxidant activities of the phenolic acids in o/w emulsions is also provided as an in vitro lipid-based model system. Exploring the interfacial activity of phenolic acids could help to further elucidate their potential health properties against oxidative stress conditions of biological membranes (such as lipoproteins). Finally, this review reports on the latest literature evidence concerning specific biochemical properties of the examined phenolic acids.

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Section: Gallic Acidmentioning

confidence: 90%

Phenolic Acids of Plant Origin—A Review on Their Antioxidant Activity In Vitro (O/W Emulsion Systems) Along with Their in Vivo Health Biochemical Properties

Kiokias

Proestos

Oreopoulou

2020

Foods

164

View full text Add to dashboard Cite

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“…It is now well understood that oxidative stress, produced by isoproterenol (ISO) is mediated through free radicals or reactive oxygen species (ROS), as evidenced by marked increase in tissue lipid peroxidation (LPO) and decreased levels of antioxidants such as superoxide dismutase (SOD), catalase (CAT) and reduced glutathione (GSH), which play a major role in the protection from myocardial infarction (MI) 6 . Therefore, any compound known as strong antioxidant is believed to protect the cardiac tissues from MI.…”

Section: Introductionmentioning

confidence: 99%

Preventive effect of Agnucastoside C against Isoproterenol-induced myocardial injury

Panda

Kar

Biswas

2017

Sci Rep

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An iridoid glycoside, agnucastoside C (ACC) was isolated from the leaves of Moringa oliefera and its cardio protective potential was investigated in adult rats by examining the effects of this test compound, ACC at 30 mg/kg for 14 days in isoproterenol (100 mg/kg)-induced myocardial injury. Isoproterenol (ISO) administration induced the myocardial injury as evidenced by the altered ECG pattern with ST-segment elevation and an increase in the levels of cardiac injury markers including troponin-I, creatine kinase-MB, alanine transaminase, aspartate transaminase, lactate dehydrogenase; inflammatory markers, interleukine-6 and tumor necrosis factor. In this group, there was also an increase in cardiac lipid peroxidation and a decrease in cellular antioxidants. However, pretreatment with ACC maintained the normal ECG pattern and nearly normal levels of all the cardiac markers in ISO-induced animals. Electron microscopic and histological studies also showed marked reduction in ISO-induced cardiac damages including infarct size by ACC. Analysis by 2-DE revealed the involvement of 19 different cardiac proteins, associated with energy metabolism, oxidative stress and maintenance of cytoskeleton. The expression of those proteins were altered by ISO, but maintained in ACC pretreated rats. Our findings reveal the potential of isolated ACC in the prevention of myocardial damage.

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“…Another report showed that GA could protect the heart by directly combination with free radicals and lead to inactivate them, which may suppress the intracellular concentration of free radicals ( Priscilla and Prince, 2009 ). In addition, GA was proved to present negative chronotropic and inotropic effects in isoproterenol induced myocardial damage, which is similar to propranolol ( Nwokocha et al, 2017 ).…”

Section: Introductionmentioning

confidence: 85%

Comparative Pharmacokinetics of Gallic Acid After Oral Administration of Gallic Acid Monohydrate in Normal and Isoproterenol-Induced Myocardial Infarcted Rats

Fan

Jin

et al. 2018

Front. Pharmacol.

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Gallic acid (GA) is a polyphenolic natural product widely distributed in food, beverage, and traditional Chinese herbs with beneficial effects on the cardiovascular system. In this research, a comparative study was conducted to investigate the possible difference of pharmacokinetic process in normal and isoproterenol-induced myocardial infarcted rats after oral administration of GA monohydrate with the dose of 50 and 100 mg/kg, respectively. Quantification of GA in rat plasma was achieved by using a simple and rapid high-performance liquid chromatographic method. The results revealed that pharmacokinetics of GA were greatly different between normal and pathological state. GA exhibited slower absorption into the bloodstream, and yielded 1.7-fold (50 mg/kg GA) and 1.3-fold (100 mg/kg GA) less values of area under concentration–time curve as well as 2.5-fold lower of maximum blood concentration (Cmax) in MI rats than those in normal rats. In addition, significant prolonged T1/2 and MRT as well as decreased CL were also registered in MI rats. Our findings suggest that myocardial infarction could alter the pharmacokinetic process of GA, and thus the potential pharmacokinetic differences of herbal preparations (or dietary nutrition) containing GA between normal and pathological conditions should be brought to the forefront seriously in clinical practice.

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Aqueous extract from leaf of Artocarpus altilis provides cardio-protection from isoproterenol induced myocardial damage in rats: Negative chronotropic and inotropic effects

Cited by 32 publications

References 30 publications

Phenolic Acids of Plant Origin—A Review on Their Antioxidant Activity In Vitro (O/W Emulsion Systems) Along with Their in Vivo Health Biochemical Properties

Phenolic Acids of Plant Origin—A Review on Their Antioxidant Activity In Vitro (O/W Emulsion Systems) Along with Their in Vivo Health Biochemical Properties

Preventive effect of Agnucastoside C against Isoproterenol-induced myocardial injury

Comparative Pharmacokinetics of Gallic Acid After Oral Administration of Gallic Acid Monohydrate in Normal and Isoproterenol-Induced Myocardial Infarcted Rats

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