Aqueous core microcapsules as potential long-acting release systems for hydrophilic drugs

Abuhamdan, Raghad; Al-Anati, Bayan; Thaher, Yazan Al; Shraideh, Z.; Alkawareek, Mahmoud Y.; Abulateefeh, Samer R.

doi:10.1016/j.ijpharm.2021.120926

Cited by 9 publications

(6 citation statements)

References 63 publications

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“…The PGla-PPBP copolymer was synthesized by RAFT using trithiocarbonate as an initiator while MAGlaAc and MAPBP as hydrophilic and hydrophobic blocks. 29 The synthesis routes and typical 1 H NMR spectra of the PGla-PPBP block copolymers are illustrated in Figures 2 and 3 . All chemical shifts were expressed in parts per million (δ) relative to the tetramethylsilane signal.…”

Section: Resultsmentioning

confidence: 99%

“…The PGla-PPBP copolymer was synthesized by RAFT using trithiocarbonate as an initiator while MAGlaAc and MAPBP as hydrophilic and hydrophobic blocks. 29 The synthesis routes and typical 1 Intravenous administration is the mostly used route for nanomedicines in cancer treatment and therefore the hemolysis induced by nanoparticles should be of concern. 30 As shown in Figure 3F, PGla-PPBP nanoparticles had no obvious hemolysis at each tested concentration, showing good safety for intravenous injection.…”

Section: Characterization Of Pgla-ppbpmentioning

confidence: 99%

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ROS-responsive Galactosylated-nanoparticles with Doxorubicin Entrapment for Triple Negative Breast Cancer Therapy

Zhou¹,

Li²,

Zang³

et al. 2023

IJN

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Background Triple negative breast cancer (TNBC) is one of the most aggressive tumors with high metastasis and mortality, which constitutes 15~20% of all breast cancers. Chemotherapy remains main therapeutic option in the treatment of patients with TNBC. Methods We developed reactive oxygen species (ROS)-responsive galactosylated nanoparticles (DOX@NPs) as an efficiently targeted carrier for doxorubicin (DOX) delivery to inhibit the growth of TNBC in vitro and in vivo. DOX@NPs were composed of polyacrylate galactose and phenylboronic derivatives conjugation. The in vitro cytotoxicity, cellular uptake, cell apoptosis and cycle distribution of tumor cells treated with different formulations were investigated. Meanwhile in vivo biodistribution and antitumor effects were investigated in a 4T1 tumor-bearing mouse model. Results DOX@NPs showed good ROS responsiveness and rapid DOX release in the presence of H 2 O 2 . Furthermore, our data suggested that DOX@NPs could effectively trigger tumor cells apoptosis and cycle arrest, efficiently accumulate into tumor sites, and suppress tumor growth without adverse side effects. Conclusion Our results suggested DOX@NP with potent potential as a promising nanocarrier for TNBC therapy, which deserved further investigation for other cancer treatment.

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Section: Resultsmentioning

confidence: 99%

“…The PGla-PPBP copolymer was synthesized by RAFT using trithiocarbonate as an initiator while MAGlaAc and MAPBP as hydrophilic and hydrophobic blocks. 29 The synthesis routes and typical 1 Intravenous administration is the mostly used route for nanomedicines in cancer treatment and therefore the hemolysis induced by nanoparticles should be of concern. 30 As shown in Figure 3F, PGla-PPBP nanoparticles had no obvious hemolysis at each tested concentration, showing good safety for intravenous injection.…”

Section: Characterization Of Pgla-ppbpmentioning

confidence: 99%

ROS-responsive Galactosylated-nanoparticles with Doxorubicin Entrapment for Triple Negative Breast Cancer Therapy

Zhou¹,

Li²,

Zang³

et al. 2023

IJN

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“…Potential biodegradable polymer capsules with controllable release are not restricted to organic phase active ingredients. Aqueous core microcapsules were prepared by Abuhamdan et al 282 based on an internal phase separation method. 35,283 PLGA and PLA polymer at varying quantities and ratios were dissolved in an oil phase followed by dropwise addition of water and emulsification in mineral oil using lecithin.…”

Section: Promising Microcapsules: a Feat Of Microengineeringmentioning

confidence: 99%

Current Challenges in Microcapsule Designs and Microencapsulation Processes: A Review

Lobel,

Baiocco,

Al-Sharabi

et al. 2024

ACS Appl. Mater. Interfaces

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Microencapsulation is an advanced methodology for the protection, preservation, and/or delivery of active materials in a wide range of industrial sectors, such as pharmaceuticals, cosmetics, fragrances, paints, coatings, detergents, food products, and agrochemicals. Polymeric materials have been extensively used as microcapsule shells to provide appropriate barrier properties to achieve controlled release of the encapsulated active ingredient. However, significant limitations are associated with such capsules, including undesired leaching and the nonbiodegradable nature of the typically used polymers. In addition, the energy cost of manufacturing microcapsules is an important factor to be considered when designing microcapsule systems and the corresponding production processes. Recent factors linked to UN sustainability goals are modifying how such microencapsulation systems should be designed in pursuit of "ideal" microcapsules that are efficient, safe, cost-effective and environmentally friendly. This review provides an overview of advances in microencapsulation, with emphasis on sustainable microcapsule designs. The key evaluation techniques to assess the biodegradability of microcapsules, in compliance with recently evolving European Union requirements, are also described. Moreover, the most common methodologies for the fabrication of microcapsules are presented within the framework of their energy demand. Recent promising microcapsule designs are also highlighted for their suitability toward meeting current design requirements and stringent regulations, tackling the ongoing challenges, limitations, and opportunities.

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“…Artificial microcapsules can be used in various industrial applications, such as in cosmetics (Miyazawa et al 2000;Casanova & Santos 2016), the food industry (Yun, Devahastin & Chiewchan 2021) and biotechnology, where drug targeting is a high-potential application (Ma & Su 2013;Abuhamdan et al 2021;Ghiman et al 2022). Once in suspension in an external fluid, capsules are subjected to hydrodynamics forces, which may lead to large membrane deformation, wrinkle formation or damage.…”

Section: Introductionmentioning

confidence: 99%

“…2000; Casanova & Santos 2016), the food industry (Yun, Devahastin & Chiewchan 2021) and biotechnology, where drug targeting is a high-potential application (Ma & Su 2013; Abuhamdan et al. 2021; Ghiman et al. 2022).…”

Section: Introductionmentioning

confidence: 99%

Data-driven kinematics-consistent model-order reduction of fluid–structure interaction problems: application to deformable microcapsules in a Stokes flow

Dupont

Vuyst²,

Salsac³

2023

J. Fluid Mech.

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In this paper, we present a generic approach of a dynamical data-driven model-order reduction technique for three-dimensional fluid–structure interaction problems. A low-order continuous linear differential system is identified from snapshot solutions of a high-fidelity solver. The reduced-order model uses different ingredients, such as proper orthogonal decomposition, dynamic mode decomposition and Tikhonov-based robust identification techniques. An interpolation method is used to predict the capsule dynamics for any values of the governing non-dimensional parameters that are not in the training database. Then a dynamical system is built from the predicted solution. Numerical evidence shows the ability of the reduced model to predict the time evolution of the capsule deformation from its initial state, whatever the parameter values. Accuracy and stability properties of the resulting low-order dynamical system are analysed numerically. The numerical experiments show very good agreement, measured in terms of modified Hausdorff distance between capsule solutions of the full-order and low-order models, in the case of both confined and unconfined flows. This work is a first milestone to move towards real-time simulation of fluid–structure problems, which can be extended to nonlinear low-order systems to account for strong material and flow nonlinearities. It is a valuable innovation tool for rapid design and for the development of innovative devices.

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Aqueous core microcapsules as potential long-acting release systems for hydrophilic drugs

Cited by 9 publications

References 63 publications

ROS-responsive Galactosylated-nanoparticles with Doxorubicin Entrapment for Triple Negative Breast Cancer Therapy

ROS-responsive Galactosylated-nanoparticles with Doxorubicin Entrapment for Triple Negative Breast Cancer Therapy

Current Challenges in Microcapsule Designs and Microencapsulation Processes: A Review

Data-driven kinematics-consistent model-order reduction of fluid–structure interaction problems: application to deformable microcapsules in a Stokes flow

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