Aqueous Colloidal Mesoporous Nanoparticles with Ethenylene-Bridged Silsesquioxane Frameworks

Urata, Chihiro; Yamada, Hironori; Wakabayashi, Ryutaro; Aoyama, Yuko; Hirosawa, Shota; Arai, Soichi; Takeoka, Shinji; Yamauchi, Yusuke; Kuroda, Kazuyuki

doi:10.1021/ja201779d

Cited by 178 publications

(161 citation statements)

References 39 publications

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“…Furthermore, the key event being considered responsible for the hemolysis is the interaction with RBC membranes, while secondary metabolic effects induced by the presence of porous silica nanoparticles are being neglected by the approaches reported so far in the literature. [14][15][16]18 As it has been recently reported, 21,22,27 the dynamic interaction phenomenon occurring in biological media in which biomolecules may adsorb on a nanoparticle surface (and also desorb from it) results in a corona coating (illustrated in Figure 3b) that will play a key role in all further biological effects manifested in a living organism. In a more specific case, the influence of these coatings on Results from the N 2 adsorption branch using the BET method; b evaluated through the single-point value adsorbed at the relative pressure (P/ Positive and negative controls were taken with DI water and PBS.…”

Section: Resultsmentioning

confidence: 95%

“…Firstly, it was observed that silanol groups on mesoporous silica structures induce less hemolytic effect compared to rigid spherical nanoparticles possibly due to shape-induced effects, which determine the spatial availability of silanols on the nanoparticle-cell interface. 13 Further, it was observed that: (i) smaller Stöber silica nanoparticles (24 nm) induce a pronounced hemolytic effect when compared with bigger ones (263 nm); 14 (ii) nanostructures with high aspect ratio (nanorods) are more cytotoxic than spherical nanoparticles; 15 (iii) mesoporous silica nanostructures (MSNs) with ordered pores (MCM-41) induce a stronger hemolytic effect compared with non-ordered; 14 (iv) small mesoporous nanoparticles (20 nm) consisted of ethenylenebridged silsesquioxane present very low toxicity 16 and (v) polymers such as PEG (polyethylene glycol) can be used to coat particles in order to greatly reduce the hemolysis. 17 Furthermore, an extensive assessment of the interaction of bare and functionalized porous silica nanomaterials with RBCs concluded that SBA-15-type MSNs cause the deformation of RBCs and consequently lead to their disruption.…”

Section: Introductionmentioning

confidence: 99%

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Suppression of the hemolytic effect of mesoporous silica nanoparticles after protein corona interaction: independence of the surface microchemical environment

Paula¹,

Martinez²,

Júnior³

et al. 2012

J. Braz. Chem. Soc.

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Nanopartículas mesoporosas de sílica são conhecidas por induzirem hemólise de células vermelhas do sangue (RBCs) humano quando ensaios de citotoxicidade são feitos em solução-tampão de fosfato (PBS). Entretanto, em uma abordagem mais realista, a presença de biomoléculas do plasma sanguíneo precisa ser considerada em qualquer avaliação nanotoxicológica de nanopartículas porosas de SiO 2 quando se objetiva a sua utilização em aplicações biomédicas através de administração intravenosa. Nesse contexto, demonstrou-se neste trabalho que nanopartículas porosas de sílica não induzem nenhum efeito citotóxico em células vermelhas do sangue quando ensaios de hemólise são feitos na presença de plasma sanguíneo, independentemente da carga superficial (positiva ou negativa) da nanopartícula. A ausência de hemólise está principalmente associada à adsorção de proteínas do plasma sobre a superfície das nanopartículas, levando à formação de um recobrimento proteico estável (denominado protein corona ou PC) que blinda o ambiente microquímico original das nanopartículas.Mesoporous silica nanoparticles are known to induce the hemolysis of human red blood cells (RBCs) when citotoxicity assays are performed in a phosphate buffer solution (PBS). However, in a more realistic approach, the presence of blood plasma biomolecules must be considered in any nanotoxicological evaluation of porous SiO 2 nanoparticles when biomedical applications through intravenous administration are aimed. In this context, it is demonstrated in this work that porous silica nanoparticles do not induce any cytotoxic effect on RBCs when hemolysis assay is done in the presence of blood plasma, regardless the surface charge (positive or negative) of the nanoparticle. The absence of hemolysis is mainly associated with the adsorption of plasma proteins on the nanoparticle surface, which leads to the formation of a stable protein coating (called protein corona or PC) that shields the original microchemical environment of bare nanoparticles.Keywords: nanoparticles, SiO 2 , mesopores, hemolytic effect, protein corona IntroductionSince porous silica nanoparticles were elected as possible protagonists in a future revolution of several medical processes of theranosis, they have been widely studied during the last decade through the host-guest approach, thus resulting in promising perspectives mainly in the areas of detection 1-3 and treatment of tumors. [4][5][6][7] While part of the scientific community creatively advances towards the engineering of porous silica nanostructures, others are acting in a proactive approach by considering environmental and toxicological effects of nano-based silica materials. In the latter context, several in vitro citotoxicity assays indicated a very high biocompatibility of porous silica nanoparticles. [8][9][10] However, a desirable in vivo biocompatibility is not straightforward. For instance, it is well known that amorphous silica particles induce toxicity on human red blood cells (RBCs) and, consequently, this test is being used as a ke...

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Section: Resultsmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Suppression of the hemolytic effect of mesoporous silica nanoparticles after protein corona interaction: independence of the surface microchemical environment

Paula¹,

Martinez²,

Júnior³

et al. 2012

J. Braz. Chem. Soc.

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“…Recently, Kuroda et al reported highly dispersed mesoporous nanoparticles with silsesquioxane frameworks and ethenylene-bridged groups. 202 The particle size was extremely uniform, with an average diameter of 20 nm.…”

Section: Novelties In Surfactant-templated Mesoporous Materialsmentioning

confidence: 99%

Templated Synthesis for Nanoarchitectured Porous Materials

Malgras

Kamachi

et al. 2015

Bulletin of the Chemical Society of Japan

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520

233

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“…However, colloidal mesoporous organosiloxane nanoparticles can be prepared by using only bridged silsesquioxanes. Our group has succeeded in preparing colloidal mesoporous organosiloxane nanoparticles by using bis(triethoxysilyl)ethenylene or ethynylene as a single source (Figure 16(left)), 158 though the adsorption isotherm did not clearly show the presence of mesopores. Our ongoing research shows that an increase in the pH of the precursor solution may lead to the formation of clearer mesopores in the system.…”

Section: Preparation Of Colloidal Msns By Using Bridgedmentioning

confidence: 99%

Colloidal Mesoporous Silica Nanoparticles

Yamamoto

Kuroda

2016

Bulletin of the Chemical Society of Japan

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197

100

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IMMA. His current research interests include mesostructured materials, and several fields of inorganic materials chemistry. Some examples are intercalation chemistry, silicate chemistry, inorganic polymers, sol-gel chemistry, inorganic-organic hybrids, and self-organized materials. AbstractMesoporous silica nanoparticles (MSNs) with colloidal stability have attracted increasing interest because of their important properties, such as high transparency and cell uptake. Colloidal MSNs are comprehensively reviewed from the viewpoints of their preparation, characterization, and applications which include biomedical, catalytic, and optical materials. The following two points have been emphasized. The first point is that this review covers the widest range of introduction and discussion of the preparation and applications of both colloidal and noncolloidal MSNs. The second point is that this account contains a discussion from the viewpoints of both inorganic and colloid chemistries. After the introduction of the historical background of preparation of MSNs, preparative methods of colloidal MSNs and the major factors for the preparation of nanosized and colloidal MSNs are discussed. The methods to control the size, composition, morphology, and pore size of MSNs are also presented. Appropriate methods to obtain MSNs with high colloidal dispersibility are also discussed. Applications of colloidal MSNs are introduced with an emphasis on the colloidal stability. Issues to be addressed for further developments of colloidal MSNs are finally described.

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Aqueous Colloidal Mesoporous Nanoparticles with Ethenylene-Bridged Silsesquioxane Frameworks

Cited by 178 publications

References 39 publications

Suppression of the hemolytic effect of mesoporous silica nanoparticles after protein corona interaction: independence of the surface microchemical environment

Suppression of the hemolytic effect of mesoporous silica nanoparticles after protein corona interaction: independence of the surface microchemical environment

Templated Synthesis for Nanoarchitectured Porous Materials

Colloidal Mesoporous Silica Nanoparticles

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