Aqueous Cichorium intybus L. seed extract may protect against acute palmitate-induced impairment in cultured human umbilical vein endothelial cells by adjusting the Akt/eNOS pathway, ROS: NO ratio and ET-1 concentration

Abdolahipour, Raziyeh; Nowrouzi, Azin; Khalili, Masoumeh; Meysamie, Alipasha; Ardalani, Samin

doi:10.1007/s40200-020-00603-3

Cited by 4 publications

(3 citation statements)

References 92 publications

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“…Ischemic stroke is a common brain disease, whose pathogenesis is closely related to external environment, psychological factors, and self-immunity. Clinically, the symptoms of ischemic stroke are coma, blurred consciousness, language function, and sensory nerve disorders, which may cause severe loss of activity [13][14][15]. Patients with ischemic stroke are very prone to ischemia, resulting in hypoxic necrosis of neurons in brain tissue, damage to neurons, and irreversible cell death, which will have a huge impact on the patient's neurological function, and the disease develops rapidly.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Standardized Health Education in Patients with Ischemic Stroke on Patient Management Satisfaction and Quality of Clinical Management Services

Chen

Xiang

2022

Computational and Mathematical Methods in Medicine

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Aim. Ischemic stroke is a common brain disease, which seriously affects the quality of life of patients. The purpose of this study was to evaluate the impact of the application of standardized health education in ischemic stroke patients on patient management satisfaction and clinical management service quality. Methods. 220 patients with ischemic stroke were chosen for study target. The research objects were randomly divided into control group ( n = 110 ) and education group ( n = 110 ) by odd even number draw lots. The control group conducted conventional treatment; on the basis of the control group, the education group received standardized health education. The impact of the application of standardized health education in patients with ischemic stroke on patient management satisfaction and clinical management service quality was analyzed. Results. The number of health error items in the two groups decreased significantly after 2 months and 3 months of treatment, contrast to before admission, and the number of health error items in the education group was lower than that in the control group, and the difference was statistically significant. After 3 months of treatment, the daily activity score increased and the neurological function score decreased in the two groups, and the daily activity score in the education group was higher than that in the control group, and the neurological function score was lower than that in the control group; the difference was statistically significant. The satisfaction scores of patients in the education group in different aspects such as staff working attitude, health management, diet management, and environmental management were higher than those in the control group, and the disparity was obvious. Conclusion. The application of standardized health education in patients with ischemic stroke has certain clinical value.

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Section: Discussionmentioning

confidence: 99%

The Impact of Standardized Health Education in Patients with Ischemic Stroke on Patient Management Satisfaction and Quality of Clinical Management Services

Chen

Xiang

2022

Computational and Mathematical Methods in Medicine

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“…The higher the score, the more severe the pain. (II) Mandibular movement: the standard of mandibular movement [ 10 ] was used to evaluate the painless maximum vertical opening (MVO), left lateral excursion (LLE), and right lateral excursion (RLE) before and after therapy. (III) Clinical curative impact evaluation: Excellent: after therapy, the low back pain disappeared, the movement was unimpeded, and the sufferers were able to work and live normally; Good: the pain almost disappeared, the activity was slightly limited, but had little impact on work and life; Fair: the symptoms were improved to a certain extent, but the pain existed, affecting work and life; Poor: the symptoms were not improved or even aggravated.…”

Section: Methodsmentioning

confidence: 99%

“…Small incision reduction and suture can effectively reduce the pain of sufferers, thus effectively reduce the difficulty of operation, thus improve the clinical impact, promote the growth and repair of joints, and improve the healthy life and ability of sufferers. The recovery of neurological function plays a very important role [10][11][12]. This study formulated the relevant therapy methods for the ADD of the TMJ and could explore the therapy methods of the sufferers with ADD of the TMJ.…”

Section: Introductionmentioning

confidence: 99%

Impact of Small Incision Reduction and Suture Linked with Functional Appliance of Sufferers with Irrecoverable TMJ Anterior Disc Displacement

Wei

Yan

Sun

et al. 2022

Computational and Mathematical Methods in Medicine

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Background and Aim. Irrecoverable anterior disc displacement (ADD) of temporomandibular joint (TMJ) seriously affects the quality of life of patients. This research was aimed to explore the recovery effect of small incision reduction and suture on patients. Methods. 90 patients with irreducible ADD of TMJ treated from August 2020 to August 2021 were acquired in our hospital. They were randomly divided into control group and trial group randomly. There were 45 patients in each group. The sufferers in the control group were treated with oral drug therapy and small incision reduction and suture, while those in the trial group were treated with small incision reduction and suture linked with functional appliance. The pain score, dysfunction, joint function recovery, facial improvement, and clinical impacts of the two groups were contrasted. Results. Compared with that in the control group at 1 week, 4 weeks, and 6 months after therapy, the pain score in the trial group was markedly higher. After therapy, in the two groups, maximum vertical opening (MVO), left lateral excursion (LLE), and right lateral excursion (RLE) levels were markedly higher than those in the control group. The MRI score of the trial group was markedly higher than that of the control group at 1 week, 4 weeks, and 6 months after therapy, and the total effective rate of the trial group was markedly higher than that of the control group. Conclusion. The use of small incision reduction and suture linked with functional appliance in the therapy of sufferers with irreducible ADD of TMJ is beneficial to relieve pain, promote the recovery of body function, and contribute to the recovery of joint function.

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Recent advances in molecular biology of metabolic syndrome pathophysiology: endothelial dysfunction as a potential therapeutic target

Marzoog

2022

J Diabetes Metab Disord

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Current advances in molecular pathobiology of endotheliocytes dysfunctions are promising in finding the pathogenetic links to the emergence of insulin resistance syndrome. Physiologically, human organism homeostasis is strictly controlled to maintain metabolic processes at the acquainted level. Many factors are involved in maintaining these physiological processes in the organism and any deviation is undoubtedly accompanied by specific pathologies related to the affected process. Fortunately, the body’s defense system can solve and compensate for the impaired function through its multi-level defense mechanisms. The endothelium is essential in maintaining this homeostasis through its ability to modulate the metabolic processes of the organism. Pathological activity or impairment of physiological endothelium function seems directly correlated to the emergence of metabolic syndrome. The most accepted hypothesis is that endothelium distribution is due to endoplasmic reticulum stress and unfolded protein response development, which includes inhibition of long non-coding RNAs expression, cytokines disbalance, Apelin dysregulation, glycocalyx degradation, and specific microparticles. Clinically, the enhancement or restoration of normal endothelial cells can be a target for novel therapeutic strategies since the distribution of its physiological activity impairs homeostasis and results in the progression of metabolic syndrome, and induction of its physiological activity can ameliorate insulin resistance syndrome. Novel insights on the molecular mechanisms of endothelial cell dysfunction are concisely represented in this paper to enhance the present therapeutic tactics and advance the research forward to find new therapeutic targets.

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Aqueous Cichorium intybus L. seed extract may protect against acute palmitate-induced impairment in cultured human umbilical vein endothelial cells by adjusting the Akt/eNOS pathway, ROS: NO ratio and ET-1 concentration

Cited by 4 publications

References 92 publications

The Impact of Standardized Health Education in Patients with Ischemic Stroke on Patient Management Satisfaction and Quality of Clinical Management Services

The Impact of Standardized Health Education in Patients with Ischemic Stroke on Patient Management Satisfaction and Quality of Clinical Management Services

Impact of Small Incision Reduction and Suture Linked with Functional Appliance of Sufferers with Irrecoverable TMJ Anterior Disc Displacement

Recent advances in molecular biology of metabolic syndrome pathophysiology: endothelial dysfunction as a potential therapeutic target

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