Aqueous bark extract of Terminalia arjuna protects against cadmium-induced hepatic and cardiac injuries in male Wistar rats through antioxidative mechanisms

Bhattacharjee, Bharati; Pal, Palash Kumar; Ghosh, Arnab; Mishra, Sanatan; Chattopadhyay, Aindrila; Bandyopadhyay, Debasish

doi:10.1016/j.fct.2018.12.008

Cited by 30 publications

(15 citation statements)

References 74 publications

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“…Another study evaluating the histopathological changes in the heart of male albino rats treated with 200 mg/L Cd for 8 weeks reported focal hyaline degeneration and perivascular fibrosis with narrowed lumen of cardiac blood vessels after 4 weeks, hyaline degeneration with focal areas of coagulative necrosis and interstitial fibrosis in the left ventricle after 8 weeks [92]. The results of these studies showed that Cd mediates tissue damage in the cardiovascular system by generating ROS inducing oxidative stress and inhibiting the expression of and depleting vital antioxidant enzymes [90] [91] [92].…”

Section: Cadmium-induced Tissue Injurymentioning

confidence: 87%

“…This was further supported by the depletion of collagen fiber in cardiac tissue sections stained with picrosirius red indicating fibrosis in cardiac tissues. Also reported in the study was the crosslinking of myofibrillar collagen fibers forming an irregular branching pattern and complicated matrix network [90]. In addition to the cardiac tissues, Cd alters the aorta's histological integrity as evidenced by the induction of hypertrophic aortic wall remodeling by hyperplasia of smooth muscle cells, increased collagen deposition, decreased elastin and increased aortic medial wall matrix metalloproteinases [91].…”

Section: Cadmium-induced Tissue Injurymentioning

confidence: 93%

“…In a study, male Wistar rats treated with 0.44 mg Cd/kg b.w. every alternate day for 15 days found significant increase in the amount of Cd deposited in the heart (4 µg/g) and an increase in the levels of biomarkers of organ damage [90]. Histopathological analysis showed profound degeneration along with capillary dilatation, vascular congestion and necrosis of the myocardial fibers.…”

Section: Cadmium-induced Tissue Injurymentioning

confidence: 94%

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Cadmium Toxicity: Oxidative Stress, Inflammation and Tissue Injury

Das¹,

Al‐Naemi²

2019

ODEM

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Cadmium is a known environmental pollutant targeting various organs. Often implicated in cadmium toxicology is the formation of reactive oxygen species, overwhelming the free radical scavenging mechanisms and inducing oxidative stress. Acute cadmium intoxication has been shown to reduce antioxidant enzyme activity and induce oxidative stress. However, chronic intoxication has obscure outcomes in oxidative stress while the cell makes adjustments to overcome the toxicant load. Also linked with the occurrence of oxidative stress is inflammation. Stimulation of acute or chronic inflammation is mediated by different cascades. However, key events include activation of transcription factor, NF-κB and release of pro-inflammatory cytokines. Both oxidative stress and inflammation are implicated simultaneously in pathogenesis and induction of multi-organ tissue damage under cadmium exposure. This article reviews the impact of acute and chronic cadmium intoxication on inducing oxidative stress, inflammation and thereby inflicting tissue damage.

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Section: Cadmium-induced Tissue Injurymentioning

confidence: 87%

Section: Cadmium-induced Tissue Injurymentioning

confidence: 93%

Section: Cadmium-induced Tissue Injurymentioning

confidence: 94%

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Cadmium Toxicity: Oxidative Stress, Inflammation and Tissue Injury

Das¹,

Al‐Naemi²

2019

ODEM

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“…Studies have also reported the deposition and accumulation of cadmium in the heart and arterial tissue in both humans ( Egger et al, 2019 ) as well as animal models ( Erdem et al, 2016 ; Young et al, 2019 ). Histopathological studies of cardiovascular tissues after cadmium exposure have reported alteration of tissue structure and integrity, fibrosis and depletion of collagen fiber ( Veličkov et al, 2013 ; Sangartit et al, 2014 ; Saleh and Awadin, 2017 ; Bhattacharjee et al, 2019 ). It was reported that the heart tissue accumulated the lowest amount of cadmium after the liver and kidney ( Erdem et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Chronic Cadmium Exposure Alters Cardiac Matrix Metalloproteinases in the Heart of Sprague-Dawley Rat

et al. 2021

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The aim of this study was to evaluate the role of chronic cadmium exposure in modulating cardiac matrix metalloproteinases (MMPs) in the heart of rats. Adult male Sprague-Dawley rats were exposed to 15 ppm CdCl2 in drinking water for 10 weeks followed by withdrawal of cadmium treatment for 4 weeks. Following the completion of the treatment, gene expression of inflammatory mediators (IL-1β, IL-6, IL-10, TNF-α and NF-κB), protein expression of MMP-2, MMP-9 and their respective inhibitors- TIMP-1 and TIMP-2, and gelatinolytic activity of MMP-2 and MMP-9 were determined. At the protein level, cadmium incites a differential effect on the expression and activity of gelatinases and their endogenous inhibitors in an exposure-dependent manner. Results also show that the administered cadmium dose elicits an inflammatory response until week 10 that slightly diminishes after 4 weeks. This study provides evidence of cadmium-induced imbalance in the MMP-TIMP system in the cardiac tissue. This imbalance may be mediated by cadmium-induced inflammation that could contribute to various cardiovascular pathologies.

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“…Immediately after dissection, the heart, liver and kidney tissues and the mitochondria isolated from each tissue were fixed in 2.5% cold glutaraldehyde for 24-48 h, then the SEM analysis was performed following the method of Watanabe et al (48) with some modifications (49). Briefly, the tissue sections, as well as the mitochondrial smear, were washed 3-4 times in phosphate buffer (50 mM, pH 7.2), then, the samples were dehydrated through ascending grades of alcohol treatment (30, 50, 70, 90, and 100%; each for 10 min).…”

Section: Morphological Analysis With Scanning Electron Microscopy (Sem)mentioning

confidence: 99%

Melatonin protects against cadmium-induced oxidative damage in different tissues of rat: a mechanistic insight

et al. 2019

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Cadmium (Cd) is a notorious environmental pollutant known for its wide range of toxicities to organisms. Thus, the present study is designed to examine whether melatonin, a potent antioxidant, protects against Cd-induced oxidative damage in the heart, liver and kidney of rats. Cd treatment at a dose of 0.44 mg/kg for 15 days caused severe damage in all these organs. These included significantly increased activities of SGPT, SGOT, lactate dehydrogenase- 1 and 5 and ALP and levels of total lactate, creatinine, lipid peroxidation, protein carbonyl content and reduced glutathione while the activities of superoxide dismutases, catalase, glutathione peroxidase, glutathione reductase and glutathione-S-transferase along with mitochondrial pyruvate dehydrogenase, isocitrate dehydrogenase, α-keto glutarate dehydrogenase, succinate dehydrogenase, NADH-cytochrome-c-oxidoreductase and cytochrome-c-oxidase were significantly reduced by Cd. However, if melatonin was given orally 30 min before Cd injection, all these alterations induced by Cd were significantly preserved by melatonin. Histological observations also demonstrated that Cd exposure caused cellular lesions, promoting necrotic or apoptotic changes. Notably, all these changes were significantly protected by melatonin. The results suggest that melatonin is a beneficial molecule to ameliorate Cd-induced oxidative damage in the heart, liver and kidney tissues of rats with its powerful antioxidant capacity, heavy metal chelating activity and competition of binding sites with Cd to the GSH and catalase.

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Aqueous bark extract of Terminalia arjuna protects against cadmium-induced hepatic and cardiac injuries in male Wistar rats through antioxidative mechanisms

Cited by 30 publications

References 74 publications

Cadmium Toxicity: Oxidative Stress, Inflammation and Tissue Injury

Cadmium Toxicity: Oxidative Stress, Inflammation and Tissue Injury

Chronic Cadmium Exposure Alters Cardiac Matrix Metalloproteinases in the Heart of Sprague-Dawley Rat

Melatonin protects against cadmium-induced oxidative damage in different tissues of rat: a mechanistic insight

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