Aqueous and Ethanolic Valeriana officinalis Extracts Change the Binding of Ligands to Glutamate Receptors

Valle-Mojica, Lisa M. Del; Cordero-Hernández, José M.; González-Medina, Giselle; Ramos-Vélez, Igmeris; Berríos-Cartagena, Nairimer; Torres-Hernández, Bianca A.; Ortíz, José G.

doi:10.1155/2011/891819

Cited by 17 publications

(14 citation statements)

References 43 publications

(35 reference statements)

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“…This study, for first time, showed that the effects of valerian and valerenic acid were significantly antagonized in the presence of L-AP3 and EGLU (mGluR antagonists). Our in vivo results clearly demonstrated that Valeriana officinalis and valerenic acid interact with zebrafish group I and II mGluR, confirming our previous in vitro studies [8,9]. Zebrafish are a valuable in vivo biological tool for large screens of phytochemical (natural products) and for studying their physiological response.…”

supporting

confidence: 88%

“…Previous research demonstrated that valerian interacts with and modulates GABA receptors [4], is a partial agonist of the 5-HT(5a) receptor [5] and mediates the activation of adenosine receptors [6,7] but the exact mechanism of action of valerian is still unknown. Studies from our lab reveal that valerian extracts also interact with metabotropic glutamate receptors [8,9]. During the past decades, zebrafish have emerged as a useful model species and a powerful bioassay tool in different research areas [10,11].…”

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confidence: 99%

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Anxiolytic Properties of Valeriana officinalis in the Zebrafish: A Possible Role for Metabotropic Glutamate Receptors

Valle-Mojica

Ortíz

2012

Planta Med

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Valerian extract is used in complementary and alternative medicine for its anxiolytic and sedative properties. Our previous research demonstrated valerian interactions with glutamate receptors. The purpose of this study was to determine if valerian anxiolytic properties are mediated by metabotropic glutamate receptors (mGluR) such as mGluR (1/5) (mGluR I) and mGluR (2/3) (mGluR II). Adult wild-type zebrafish (Danio rerio) prefer the black compartment and avoid the white compartment in the dark/light preference task. Zebrafish exposed to 1 mg/mL of valerian extract or 0.00117 mg/mL valerenic acid increased their residence time in the white side by 84.61 ± 6.55 % and 58.30 ± 8.97 %, respectively. LAP3 (mGluR I antagonist) and EGLU (mGluR II antagonist) significantly inhibited the effects of valerian and valerenic acid. These results demonstrated that valerian and valerenic acid have anxiolytic properties in the zebrafish. Moreover, the selective interaction of valerian with mGluR I and II represent an alternative explanation for the anxiolytic properties of this plant and support the role of mGluR in anxiety.

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confidence: 88%

mentioning

confidence: 99%

Anxiolytic Properties of Valeriana officinalis in the Zebrafish: A Possible Role for Metabotropic Glutamate Receptors

Valle-Mojica

Ortíz

2012

Planta Med

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“…Other studies indicate that VE has antioxidant and neuroprotective effects [6,7,8,9]. Furthermore, VE modulates brain neurotransmitters [10,11,12,13,14], and shows antianxiety, antidepressant, and antiepileptic activity in animal models [15,16]. …”

Section: Introductionmentioning

confidence: 99%

Valeriana officinalis Root Extract Modulates Cortical Excitatory Circuits in Humans

et al. 2017

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Background:Valeriana officinalis extract (VE) is a popular herbal medicine used for the treatment of anxiety and sleep disorders. Although the anxiolytic and sedative effects are mainly attributed to the modulation of GABA-ergic transmission, the mechanism of action has not been fully investigated in humans. Noninvasive brain stimulation protocols can be used to elucidate the mechanisms of action of psychoactive substances at the cortical level in humans. In this study, we investigated the effects of a single dose of VE on cortical excitability as assessed with transcranial magnetic stimulation (TMS). Methods: Fifteen healthy volunteers participated in a double-blind, randomized, cross-over, placebo-controlled study. Subjects were required to take either 900 mg of VE (valerenic acid 0.8%) or placebo (an equal dose of vitamin E). Motor cortex excitability was studied by single and paired TMS before and at 1 h and 6 h after the oral administration. Cortical excitability was assessed using different TMS parameters: resting motor threshold, motor-evoked potential amplitude, cortical silent period, short-interval intracortical inhibition, and intracortical facilitation. Furthermore, we assessed sensorimotor integration by short-latency and long-latency afferent inhibition. Results: We found a significant reduction in ICF, without any significant changes in other TMS measures of motor cortex excitability. The amount of ICF returned to baseline value 6 h after the intake of the VE. Conclusion: A single oral dose of VE modulates intracortical facilitatory circuits. Our results in healthy subjects could be predictive markers of treatment response in patients and further support the use of pharmaco-TMS to investigate the neuropsychiatric effects of herbal therapies in humans.

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“…A variety of therapeutic effects, including hypnotic, sedative, anxiolytic, anticonvulsant, and antidepressant functions, have been determined for valerian (Wagner et al, 1980;Oshima et al, 1995;Andreatini et al, 2002;Del Valle-Mojica et al, 2011;Torres-Hernández et al, 2015). Some studies have tested the effects of valerian only, or in combination with other pharmaceuticals or herbal medicines in treating neurological diseases.…”

Section: Introductionmentioning

confidence: 99%

Valeriana officinalis and melatonin: Evaluation of the effects in Drosophila melanogaster rapid iterative negative geotaxis (RING) test

Cheuczuk¹,

Freitas²,

Vaz³

et al. 2017

J. Med. Plants Res.

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The rapid iterative negative geotaxis (RING) assay is a commonly used behavioral test in Drosophila based on digital imaging of flies and requires minimal equipment and space. Larval mobility can be used to reliably determine the effect of drugs on locomotion in Drosophila larvae. The effects of Valeriana officinalis extract (VoE) and melatonin (ME) were tested in Drosophila melanogaster flies and larvae. In the RING assay, the locomotor activity of flies was reduced to 30.6, 72 and 70.4% when exposed to 10 mg/ml VoE, 8 mM ME, and a combination of 8 mM ME + 10 mg/ml VoE, respectively. The performance index (PI) was reduced to 68.9% (P = 0.0058), 33.3% (P = 0.0001), and 70% (P = 0.0013) when flies were exposed to 8 mM ME, 10 mg/ml VoE, and a combination of 8 mM ME + 10 mg/ml VoE, respectively. The number of body wall contractions of Drosophila larvae (nBWC) was reduced to 47.8, 37.7 and 38.5% when larvae were exposed to 8 mM ME, 10 mg/ml VoE, and a combination of 8 mM ME + 10 mg/ml VoE, respectively. The displacement velocity (V 0 ) of larvae decreased significantly to 67.6, 60.1 and 55.6% when larvae were exposed to 8 mM ME, 10 mg/ml VoE, and a combination of 10 mg/ml VoE + 8 mM ME, respectively (P < 0.05). The effects of the VoE extract were not synergistic with ME as demonstrated by the RING assay, nBWC, and V 0 . Based on these results, valerian root extracts have demonstrated sedative effects that are better than those of melatonin in fruit flies, but did not show any increase in sedative effect when combined with melatonin.

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Aqueous and Ethanolic Valeriana officinalis Extracts Change the Binding of Ligands to Glutamate Receptors

Cited by 17 publications

References 43 publications

Anxiolytic Properties of Valeriana officinalis in the Zebrafish: A Possible Role for Metabotropic Glutamate Receptors

Anxiolytic Properties of Valeriana officinalis in the Zebrafish: A Possible Role for Metabotropic Glutamate Receptors

<b><i>Valeriana officinalis</i></b> Root Extract Modulates Cortical Excitatory Circuits in Humans

Valeriana officinalis and melatonin: Evaluation of the effects in Drosophila melanogaster rapid iterative negative geotaxis (RING) test

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