AQUAVAN® Injection, a Water-soluble Prodrug of Propofol, as a Bolus Injection: A Phase I Dose-escalation Comparison with DIPRIVAN® (Part 2): Pharmacodynamics and Safety: Retracted

Abstract

Bolus administration of AQ achieves LOCverbal at a similar time as an equipotent amount of PropofolD but shows a longer time to BISpeak and prolonged pharmacodynamics. For both drugs, excellent drug safety was achieved, although there was a tendency of fewer and shorter duration of apneas for AQ.

Pharmacokinetics and Pharmacodynamics of GPI 15715 or Fospropofol (Aquavan Injection) — A Water-Soluble Propofol Prodrug

“…In summary, GPI 15715 or fospropofol has been extensively studied in human volunteers. The pharmacokinetic differences for propofol G we found are in agreement with the results of other study groups Struys et al 2005), but the higher pharmacodynamic potency of propofol G compared to propofol L that we found has not been proved in other investigations.…”

“…Besides the studies presented above, which were the first two investigating possible PK/PD differences after infusion and TCI-infusion of GPI 15715 or fospropofol in volunteers (Fechner et al 2004;Fechner et al 2003), two other combined studies presenting the PK/PD results after bolus dosing of GPI 15715 or fospropofol compared to lipid-formulated propofol in human volunteers have been published Struys et al 2005). They found a combined pharmacokinetic model with three compartments for GPI 15715 and three compartments for propofol G best described their data.…”

Comparasion between effects of lidocaine, magnesium- sulfate and ondansetron on propofol injection pain (lidocaine, magnesium- sulfate, ondasentrone and propofol application)

“…Međutim, samo je fospropofol dinatrijum odobren za korišcenje od strane Američke agencije za hranu i lekove 6 . Fospropofol izaziva manji lokalni bol prilikom aplikacije 16 . Ondansetron je poznat kao centralni antiemetik i najčešće se koristi kod postoperativne mučni-ne i povraćanja.…”

Understanding modes of moderate sedation during gastrointestinal procedures: a current review of the literature

“…Fospropofol disodium (Aquavan Injection) is a novel sedative/hypnotic, water-soluble prodrug of propofol with pharmacokinetic and pharmacodynamic properties that differ from those of propofol emulsion [62][63][64]. Aquavan is hydrolyzed by alkaline phosphatase to release propofol [62][63][64][65].…”

“…Aquavan is hydrolyzed by alkaline phosphatase to release propofol [62][63][64][65]. The pharmacokinetic profile of Aquavan is characterized by avoidance of the high peak plasma concentrations seen with the lipid emulsion formulation of propofol (Fig.…”