Aquatic toxicity of ivermectin in cattle dung assessed using microcosms

Mesa, Leticia Mariana; Lindt, I.; Negro, Leandro; Gutiérrez, María Florencia; Mayora, Gisela; Montalto, Luciana; Ballent, Mariana; Lifschitz, Adrián Luis

doi:10.1016/j.ecoenv.2017.06.016

Cited by 40 publications

(22 citation statements)

References 53 publications

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“…4). Further, the concentration of IVM in the sediment of wetlands were stable during the entire study period, and this result was in accordance with previous works (Kövecses and Marcogliese, 2005;Sanderson et al, 2007;Egeler et al, 2010.;Schweitzer et al, 2010;Mesa et al, 2017). High values of IVM in macrophytes and invertebrates found in the days before injection of cattle with IVM and after a high-water period (more than three months) reinforce this statement.…”

Section: Discussionsupporting

confidence: 92%

“…Only a few laboratory studies have addressed exposure of aquatic assemblages via dung (Schweitzer et al, 2010;Mesa et al, 2017) and sediment spiked with IVM (Davies et al, 1998;Allen et al, 2007;Egeler et al, 2010). Consistently, these laboratory experiments have documented concentrations of IVM sediment, Salvinia sp., and invertebrates such as Pomacea sp.…”

Section: Introductionmentioning

confidence: 97%

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Concentration and environmental fate of ivermectin in floodplain wetlands: An ecosystem approach

Mesa

Gutiérrez

Montalto

et al. 2020

Science of The Total Environment

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 97%

Concentration and environmental fate of ivermectin in floodplain wetlands: An ecosystem approach

Mesa

Gutiérrez

Montalto

et al. 2020

Science of The Total Environment

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“…There are eight different isolated avermectins which comprise four pairs of homologues. One of these pairs, abamectin (ABA) (also referred to as avermectin B1, AVM), a mixture of avermectin B1a (>80%) and B1b (<20%), is one of the most widely used compounds in agriculture . However, a large number of studies show that the excessive application of ABA leads to an increase in ABA residues in crops .…”

Section: Introductionmentioning

confidence: 99%

Abamectin induces apoptosis and autophagy by inhibiting reactive oxygen species‐mediated PI3K/AKT signaling in MGC803 cells

Zhu

Zhou

et al. 2019

J Biochem & Molecular Tox

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Abamectin (ABA) is one of the most widely used compounds in agriculture and veterinary medicine. However, the cytotoxicity of ABA in human gastric cells is utterly unknown. In this study, ABA suppressed the proliferation of MGC803 cells by arresting the cell cycle at the G0/G1-phase. Moreover, ABA induced mitochondrialmediated apoptosis by inducing the loss of mitochondrial membrane potential, upregulation of Bax/Bcl-2, and activation of caspase-3. ABA significantly improved the LC3-II/LC3-I ratio and reduced P62 protein expression in a dose-dependent manner. Through detection of the reactive oxygen species (ROS) levels, we found ABA induced the accumulation of intracellular ROS and then reduced PI3K/AKT signaling activation related to MGC803 cell apoptosis and autophagy. Our results indicate that ABA exerts cytotoxic effects on human MGC803 cells through apoptosis and autophagy by inhibiting ROS-mediated PI3K/AKT signaling. Furthermore, ABA may be a potential risk to human gastric health. K E Y W O R D S abamectin, AKT, apoptosis, autophagy, PI3K, reactive oxygen species

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“…In the case of ivermectin, only a few studies addressed its bioaccumulation in aquatic invertebrates, such as the sediment-dwelling worm Lumbriculus variegatus Müller (Oligochaeta) 23 , the zooplanktonic microcrustacean 24 . The present study is thus the first to analyse the bioaccumulation of an organic chemical, such as ivermectin, in dung beetles.…”

Section: Discussionmentioning

confidence: 99%

Biomagnification and body distribution of ivermectin in dung beetles

Verdú

Cortez

Ortiz

et al. 2020

Sci Rep

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A terrestrial test system to investigate the biomagnification potential and tissue-specific distribution of ivermectin, a widely used parasiticide, in the non-target dung beetle Thorectes lusitanicus (Jekel) was developed and validated. Biomagnification kinetics of ivermectin in T. lusitanicus was investigated by following uptake, elimination, and distribution of the compound in dung beetles feeding on contaminated faeces. Results showed that ivermectin was biomagnified in adults of T. lusitanicus when exposed to non-lethal doses via food uptake. Ivermectin was quickly transferred from the gut to the haemolymph, generating a biomagnification factor (BMF k) three times higher in the haemolymph than in the gut after an uptake period of 12 days. The fat body appeared to exert a major role on the biomagnification of ivermectin in the insect body, showing a BMF k 1.6 times higher than in the haemolymph. The results of this study highlight that the biomagnification of ivermectin should be investigated from a global dung-based food web perspective and that the use of these antiparasitic substances should be monitored and controlled on a precautionary basis. Thus, we suggest that an additional effort be made in the development of standardised regulatory recommendations to guide biomagnification studies in terrestrial organisms, but also that it is necessary to adapt existing methods to assess the effects of such veterinary medical products.

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Aquatic toxicity of ivermectin in cattle dung assessed using microcosms

Cited by 40 publications

References 53 publications

Concentration and environmental fate of ivermectin in floodplain wetlands: An ecosystem approach

Concentration and environmental fate of ivermectin in floodplain wetlands: An ecosystem approach

Abamectin induces apoptosis and autophagy by inhibiting reactive oxygen species‐mediated PI3K/AKT signaling in MGC803 cells

Biomagnification and body distribution of ivermectin in dung beetles

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