Aquaporins in Reproductive System

Zhang, Hang; Yang, Baoxue

doi:10.1007/978-981-19-7415-1_12

Cited by 2 publications

(1 citation statement)

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“…Bull seminal plasma has high levels of SPP1 protein which greatly influences the sperm fertility (Rodríguez et al., 2000). Aquaporins ( AQPs ) gene family incriminated in sperm cell production, maturation and fertilization as well as mediating water and tiny solutes transport along the male reproductive tract (Zhang & Yang, 2023). Progressive fluid resorption, driven by aquaporins, facilitates the interactions between sperm surface and the epididymal secretory products, and influences the time of sperm storage (Da Silva et al., 2006).…”

Section: Discussionmentioning

confidence: 99%

Region‐specific gene expression profile in the epididymis of high‐ and low‐fertile dromedary camels

Rashad,

Ibrahim,

El‐Sokary

et al. 2024

Reprod Domestic Animals

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The scenario of the fertile spermatozoa with high fertilizing capability is basically dependent on gene expression‐based epididymal function. The current investigation aimed to declare the varied expression of different candidate genes (PLA2G4D, LCN15, CLUAP1, SPP1, AQP12B, DEFB110 and ESR1) relevant to spermatozoa features between the different epididymal segments in the mature dromedary camels (n = 30). Scrotal contents were collected post‐slaughtering, during the breeding season and the epididymis was separated from the testicles and divided into three segments (caput, corpus and cauda) based on its morphology and anatomical characteristics. Epididymal spermatozoa were harvested from each epididymal portion and evaluated for motility, count, viability and morphology. Samples were grouped depending on their epididymal sperm cells features into high‐fertile (n = 15) and low‐fertile (n = 15) groups. The gene expression of the candidate genes was defined in the isolated RNA from each epididymal portion tissue. The segmental sperm motion and count were significantly (p < .05 and p < .01) higher in the three epididymal parts of high‐fertile camels than the lower ones. There were some candidate genes markedly up‐regulated in its expression in epididymal head of high‐fertile camels (PLA2G4D and LCN15) and low fertile (CLUAP1), while others in the body region of the high‐fertile group (SPP1, AQP12B and DEFB110). Nevertheless, ER1 did not differ in the expression among the epididymal segments. In conclusion, the variant expression patterns of these epididymal genes in relation to the regional spermatozoa features might suggest important roles of these genes in sperm maturation process in the epididymis and focusing more interest on their potential utility as markers for male camel fertility prediction.

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Section: Discussionmentioning

confidence: 99%