Aquaporins in cancer

Ribatti, Doménico; Ranieri, Girolamo; Annese, Tiziana; Nico, Beatrice

doi:10.1016/j.bbagen.2013.09.025

Cited by 96 publications

(93 citation statements)

References 66 publications

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“…This series of processes may also be involved in the development and progression of colon cancer [14]. Therefore, several recent studies have focused on the clinical significance of AQP expression for predicting the prognosis of colon cancer [2]. …”

Section: Discussionmentioning

confidence: 99%

“…According to each subtype, AQPs are also involved in a wide range of physiologic functions and human diseases [3]. While their mechanisms and effects on cancer are still unknown, several reports have indicated a positive correlation between the histologic tumor grade and AQP expression [2]. Furthermore, clinical studies have shown that AQP activity is associated with carcinogenesis, tumor progression, and invasion for various solid tumors, such as colorectal, breast, brain, lung, and ovarian cancer [4,5,6,7,8].…”

Section: Introductionmentioning

confidence: 99%

“…Aquaporins (AQPs), a family of 13 small hydrophobic integral transmembrane water channel proteins, play a key role in transcellular and transepithelial water movement, fluid transport and cell migration [2]. According to each subtype, AQPs are also involved in a wide range of physiologic functions and human diseases [3].…”

Section: Introductionmentioning

confidence: 99%

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Expression of Aquaporin-1, Aquaporin-3, and Aquaporin-5 Correlates with Nodal Metastasis in Colon Cancer

et al. 2015

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Objectives: The clinical significance of aquaporin-1 (AQP1), aquaporin-3 (AQP3), and aquaporin-5 (AQP5) expression was analyzed in a large number of patients with colon cancer. Methods: AQP1, AQP3, and AQP5 expression was investigated based on the immunohistochemistry of tissue microarray specimens from 486 colon cancer patients who underwent curative surgery. Scores were given to the staining intensity and percentage of positive cells, and the staining score was defined as the sum of these scores then used to categorize the AQP expression as negative, weakly AQP-positive, or strongly AQP-positive. Results: A total of 298 (61.3%) patients were identified as strongly AQP1-positive (staining score ≥6), while 38 (7.8%) were strongly AQP3-positive and 145 (29.8%) were strongly AQP5-positive. The overexpression of AQP1, AQP3, and AQP5 was significantly correlated with lymph node metastasis in a multivariate logistic analysis (AQP1, p = 0.026; AQP3, p = 0.023; AQP5, p = 0.003). While the multivariate survival analysis, which included age, histology, TNM stage, and CEA level showed that the expression of AQP1, AQP3, and AQP5 had no effect on the overall survival and disease-free survival. Conclusions: The current study found a significant correlation between AQP1, AQP3, and AQP5 expression and lymph node metastasis in patients with surgically resected colon cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Expression of Aquaporin-1, Aquaporin-3, and Aquaporin-5 Correlates with Nodal Metastasis in Colon Cancer

et al. 2015

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“…In humans, there are 13 kinds of Aquaporins members divided into three subgroups as water selective AQPs, aquaglyceroporins and superaquaporins [7]. Aquaporins are found to mainly function as molecular transporters and involve in many disease progresses such as various chronic kidney disease, systemic disease and cancers [7][8][9][10]. Recent studies suggest that Aquaporins could be a promising drug target [11,12].…”

Section: Introductionmentioning

confidence: 99%

Down-regulated aquaporin 5 inhibits proliferation and migration of human epithelial ovarian cancer 3AO cells

Cao

Zhu

Zhang

et al. 2014

Journal of Ovarian Research

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Background: Recent studies suggested that aquaporins 5 (AQP5) was associated with many kinds of cancers and regulated many processes of various kinds of cancer cells. Our previous studies also demonstrated that AQP5 was highly expressed in epithelial ovarian cancer and contributed to the progress of ovarian cancer. Methods: Lentivirus for knocking-down the expression of AQP5 was prepared and verified by qPCR and Western blotting. Cell counting kit-8 (CCK8) assay and transwell assay were performed to investigate the role of AQP5 on proliferation and migration of 3AO cells. The effects of down-regulating AQP5 on tumorigenesis were tested by tumor xenografts experiments.

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“…There are up to 13 mammalian AQPs, which are found in most tissues with functions ranging from the regulation of renal water balance [1], brain-fluid homeostasis [2], triglyceride cycling between adipocytes and the liver [3] and structural integrity of the eye lens [4]. Because of this, understanding AQP function is crucial for the study of healthy ageing as well as the onset of many disease states such as brain swelling following stroke or head injury [5], nephrogenic diabetes insipidus [6,7], cataracts [8], obesity [9], cancer cell proliferation and migration [10] and tumour angiogenesis [11]. Many of these functions and diseases involve either permeability of molecules other than water, or a function of the AQP other than facilitating membrane permeability.…”

Section: Introductionmentioning

confidence: 99%

Beyond water homeostasis: Diverse functional roles of mammalian aquaporins

Kitchen

Day

Salman

et al. 2015

Biochimica et Biophysica Acta (BBA) - General Subjects

122

109

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BACKGROUND: Aquaporin (AQP) water channels are best known as passive transporters of water that are vital for water homeostasis. SCOPE OF REVIEW:AQP knockout studies in whole animals and cultured cells, along with naturally occurring human mutations suggest that the transport of neutral solutes through AQPs has important physiological roles. Emerging biophysical evidence suggests that AQPs may also facilitate gas (CO2) and cation transport. AQPs may be involved in cell signalling for volume regulation and controlling the subcellular localization of other proteins by forming macromolecular complexes. This review examines the evidence for these diverse functions of AQPs as well their physiological relevance. MAJOR CONCLUSIONS:As well as being crucial for water homeostasis, AQPs are involved in physiologically important transport of molecules other than water, regulation of surface expression of other membrane proteins, cell adhesion, and signalling in cell volume regulation. GENERAL SIGNIFICANCE:Elucidating the full range of functional roles of AQPs beyond the passive conduction of water will improve our understanding of mammalian physiology in health and disease. The functional variety of AQPs makes them an exciting drug target and could provide routes to a range of novel therapies.3

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Aquaporins in cancer

Cited by 96 publications

References 66 publications

Expression of Aquaporin-1, Aquaporin-3, and Aquaporin-5 Correlates with Nodal Metastasis in Colon Cancer

Expression of Aquaporin-1, Aquaporin-3, and Aquaporin-5 Correlates with Nodal Metastasis in Colon Cancer

Down-regulated aquaporin 5 inhibits proliferation and migration of human epithelial ovarian cancer 3AO cells

Beyond water homeostasis: Diverse functional roles of mammalian aquaporins

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