Aquaporins and Fetal Fluid Balance

Liu, Huishu; Zheng, Zhiyao; Wintour, E. M.

doi:10.1016/j.placenta.2008.07.010

Cited by 52 publications

(35 citation statements)

References 86 publications

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“…The placenta has been shown to express a spectrum of AQPs, particularly AQP1, 3, 8 and 9 (38). Importantly, AQP1 has been shown to regulate angiogenesis (39) and amniotic fluid volume (40,41,47). In this regard, our results on Aroclor1254-mediated inhibition of AQP1 are intriguing.…”

Section: Discussionmentioning

confidence: 77%

“…AQPs were first identified as water channels and are small membrane proteins (37). Although there are 13 known mammalian proteins that increase permeability of not only water but other small molecules such as glycerol and urea, their individual presence is strictly organ-specific (47). The placenta has been shown to express a spectrum of AQPs, particularly AQP1, 3, 8 and 9 (38).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Water Channel Aquaporin 1 Is a Novel Molecular Target of Polychlorinated Biphenyls for in Utero Anomalies

Tewari

Kalkunte

Murray

et al. 2009

Journal of Biological Chemistry

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Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

The Water Channel Aquaporin 1 Is a Novel Molecular Target of Polychlorinated Biphenyls for in Utero Anomalies

Tewari

Kalkunte

Murray

et al. 2009

Journal of Biological Chemistry

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“…Aquaporins (AQPs) constitute a growing family of water-specific membrane channel proteins that transport water across cell membranes [1,2] . There are currently 13 known mammalian aquaporins (AQP0-12); a subset of these molecules are capable of increasing the permeability of small molecules such as glycerol (AQP3, 7, 9) and urea (AQP3, 7,8,9).…”

Section: Introductionmentioning

confidence: 99%

Pregnant phenotype in aquaporin 8-deficient mice

et al. 2011

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Aim: Aquaporin 8 (AQP8) is expressed within the female reproductive system but its physiological function reminds to be elucidated. This study investigates the role of AQP8 during pregnancy using AQP8-knockout (AQP8-KO) mice. Methods: Homozygous AQP8-KO mice were mated, and the conception rate was recorded. AQP8-KO pregnant mice or their offspring were divided into 5 subgroups according to fetal gestational day (7, 13, 16, 18 GD) and newborn. Wild type C57 pregnant mice served as the control group. The number of pregnant mice, total embryos and atrophic embryos, as well as fetal weight, placental weight and placental area were recorded for each subgroup. The amount of amniotic fluid in each sac at 13, 16, and 18 GD was calculated. Statistical significance was determined by analysis of variance of factorial design and chi-square tests. Results: Conception rates did not differ significantly between AQP8-KO and wild type mice. AQP8-KO pregnant mice had a significantly higher number of embryos compared to wild type controls. Fetal/neonatal weight was also significantly greater in the AQP8-KO group compared to age-matched wild type controls. The amount of amniotic fluid was greater in AQP8-KO pregnant mice than wild type controls, although the FM/AFA (fetal weight/amniotic fluid amount) did not differ. While AQP8-KO placental weight was significantly larger than wild type controls, there was no evidence of placental pathology in either group. Conclusion: The results suggest that AQP8 deficiency plays an important role in pregnancy outcome.

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“…First isolated by Preston and Agre in 1991 [25], aquaporin membrane proteins play a significant role in the regulation of amniotic fluid composition and volume [26]. Aquaporins are a family of integral membrane proteins whose primary function is to dictate solute-independent transmembrane water transport [27].…”

Section: Introductionmentioning

confidence: 99%

Fetal membranes as an interface between inflammation and metabolism: Increased Aquaporin 9 expression in the presence of spontaneous labor at term and chorioamnionitis

Mittal¹,

Romero²,

Mazaki‐Tovi³

et al. 2009

The Journal of Maternal-Fetal & Neonatal Medicine

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Objective. Aquaporin 9 (AQP9) is a water channel protein characterized by its high permeability to nutrients such as lactate and glycerol, as well as urea and other small solutes. These unique properties of AQP9 suggest that this molecule may play a role in the modulation of nutrient flux through the fetal membranes in conditions associated with increased metabolic demand, such as spontaneous labor and inflammation. The objective of this study was to determine the expression of AQP9 in the chorioamniotic membranes from women with and without term labor, as well as those with preterm prelabor rupture of membranes (PPROM) with and without histologic chorioamnionitis. Study design. A cross-sectional study was performed which included patients in the following groups: (1) term not in labor (TNL; n ¼ 14); (2) term, spontaneous labor (n ¼ 14); and (3) PPROM with (n ¼ 20) and without (n ¼ 17) histologic chorioamnionitis. AQP9 mRNA expression in fetal membranes was quantified using quantitative real-time reverse transcription-polymerase chain reaction and analyzed with a linear model including gestational age as a covariate. Results. (1) AQP9 mRNA expression was identified in all chorioamniotic membrane specimens; (2) AQP9 expression in fetal membranes was significantly higher in spontaneous term labor when compared with TNL (fold change 3.6; p ¼ 0.01); and (3) Among patients with PPROM, the presence of histologic chorioamnionitis was associated with a higher expression of AQP9 in the chorioamniotic membranes compared with those from women without histologic chorioamnionitis (fold change 8.7; p 5 0.001). Conclusion. Aquaporin 9 mRNA expression is higher in the fetal membranes from patients with spontaneous term labor and those with PPROM and histologic chorioamnionitis. These findings are novel, and suggest a role for aquaporin 9 in membrane-mediated transfer of nutrients to support the increased metabolic demands associated with the host immune response of the terminal pathway of parturition and histologic chorioamnionitis.

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Aquaporins and Fetal Fluid Balance

Cited by 52 publications

References 86 publications

The Water Channel Aquaporin 1 Is a Novel Molecular Target of Polychlorinated Biphenyls for in Utero Anomalies

The Water Channel Aquaporin 1 Is a Novel Molecular Target of Polychlorinated Biphenyls for in Utero Anomalies

Pregnant phenotype in aquaporin 8-deficient mice

Fetal membranes as an interface between inflammation and metabolism: Increased Aquaporin 9 expression in the presence of spontaneous labor at term and chorioamnionitis

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