Aquaporin 6 binds calmodulin in a calcium-dependent manner

Rabaud, Nicole E.; Song, Linhua; Wang, Yiding; Agre, Peter; Yasui, Masato; Carbrey, Jennifer M.

doi:10.1016/j.bbrc.2009.03.128

Cited by 26 publications

(29 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The overexpression of AQP6 in CNs remains unexplained, as aquaporin 6 (AQP6) is an anion channel expressed primarily in the kidney and in other tissues, such as the cerebellum 21 . The calcium‐dependent binding of AQP6 to calmodulin 22 or its potential role during development 21 may be involved. Slit1 has been shown to play an important role in axonal guidance and dendritic growth of developing neurons 23 and to be related to cancer development, more particularly in neuroblastomas 24 .…”

Section: Discussionmentioning

confidence: 99%

Molecular characterization of central neurocytomas: Potential markers for tumor typing and progression

Vasiljevic¹,

Champier

Figarella‐Branger

et al. 2012

Neuropathology

View full text Add to dashboard Cite

Central neurocytomas (CNs) are rare intraventricular tumors presenting a favorable prognosis after surgery. Their transcriptomic profile is poorly characterized. We performed a microarray transcriptomic study to search for molecular markers that might improve diagnostic accuracy. Microarray analysis was performed on five CNs (3 primary and 2 recurrent CNs) using CodeLink human whole genome bioarrays, and the gene expression in CNs was compared with that in four pineal parenchymal tumors, consisting of two pineocytomas (PCs) and two pineoblastomas (PBs), other periventricular tumors which may present neuronal differentiation. We identified genes that were highly expressed in CNs compared to normal brain and might be candidates for the molecular typing of CNs. Several genes are part of the Wnt/β-catenin and sonic hedgehog signaling pathways or mainly linked to calcium function or maintenance of neural progenitors. Moreover, several genes are overexpressed in both CNs and PCs and/or PBs such as INSM1 and NEUROD4, involved in neural or neuroendocrine differentiation. The overexpression of eight candidate genes in CNs (CHRDL2, IGF2, KiSS-1, CAL2, NTS, NHLH1, RGS16 and SCGN) was confirmed by real-time RT-PCR. Of the genes overexpressed in the recurrent CNs compared to the primary CNs, AQP5, KiSS-1, FZD7, AURKB, UBE2C and PTTG1 are genes which may be involved in tumor progression. Our study shows the potential involvement of various genes in the pathogenesis of CNs. These genes could be potential candidate markers for improving the characterization of CNs and some could be involved in CN tumorigenesis.

show abstract

Section: Discussionmentioning

confidence: 99%

Molecular characterization of central neurocytomas: Potential markers for tumor typing and progression

Vasiljevic¹,

Champier

Figarella‐Branger

et al. 2012

Neuropathology

View full text Add to dashboard Cite

show abstract

“…The role of calcium in trafficking of vesicles containing AQP5 has been demonstrated in human salivary gland cells in which thapsigargin and calcium ionophores induced AQP5 trafficking (Ishikawa et al, 1998a). A putative calmodulin binding site at the N-terminus of AQP6 has also been identified (Rabaud et al, 2009). Calmodulin binding may have a role in the translocation of AQP6 to the cell surface; it is likely that trafficking of the majority of AQPs are stimulated by calcium elevations (Rabaud et al, 2009).…”

Section: Calciummentioning

confidence: 99%

“…A putative calmodulin binding site at the N-terminus of AQP6 has also been identified (Rabaud et al, 2009). Calmodulin binding may have a role in the translocation of AQP6 to the cell surface; it is likely that trafficking of the majority of AQPs are stimulated by calcium elevations (Rabaud et al, 2009). …”

Section: Calciummentioning

confidence: 99%

See 1 more Smart Citation

An emerging consensus on aquaporin translocation as a regulatory mechanism

Conner

Bill

Conner

2012

Molecular Membrane Biology

View full text Add to dashboard Cite

Water can pass through the cell membrane relatively slowly by diffusion. However, in order to maintain water homeostasis, the rapid and specific regulation of cellular water flow is mediated by the aquaporin (AQP) family of membrane protein water channels. Thirteen human AQPs have been identified to date and the majority are highly specific for water while others show selectivity for water, glycerol and other small solutes. The wide range of tissues that are known to express AQPs is reflected by their involvement in many physiological processes and diseases. Receptor mediated translocation, via hormone activation, is an established method of AQP regulation, especially for AQP2. There is now an emerging consensus that the rapid and reversible translocation of other AQPs from intracellular vesicles to the plasma membrane, triggered by a range of stimuli, can confer increased membrane permeability. This review examines new advances that have identified molecular mechanisms of AQP regulation; these include the role of cytoskeletal proteins, kinases, calcium and retention or localisation signals as well as specific triggers of AQP translocation. This article reviews current knowledge of AQP regulation with a focus on rapid and dynamic regulation of sub-cellular AQP translocation in response to a specific trigger.3

show abstract

“…AQPs have been identified to share sequence homology with calmodulin (Fotiadis et al, 2002) and calmodulin binding sites have been identified within the structure of AQP6 (Rabaud et al, 2009). Ca with an emphasis on the latter regulating AQP trafficking (Benfenati and Ferroni, 2010).…”

Section: Calciummentioning

confidence: 99%

Aquaporin Expression, Regulation and Function in the Intervertebral Disc

Snuggs¹

View full text Add to dashboard Cite

A thesis submitted in partial fulfilment of the requirements of Sheffield Hallam University for the degree of Doctor of Philosophy February 2019 2 Candidate Declaration I hereby declare that: 1. I have not been enrolled for another award of the University, or other academic or professional organisation, whilst undertaking my research degree. 2. None of the material contained in the thesis has been used in any other submission for an academic award. 3. I am aware of and understand the University's policy on plagiarism and certify that this thesis is my own work. The use of all published or other sources of material consulted have been properly and fully acknowledged. 4. The work undertaken towards the thesis has been conducted in accordance with the SHU Principles of Integrity in Research and the SHU Research Ethics Policy. 5. The word count of this thesis is 39,850.

show abstract

Aquaporin 6 binds calmodulin in a calcium-dependent manner

Cited by 26 publications

References 20 publications

Molecular characterization of central neurocytomas: Potential markers for tumor typing and progression

Molecular characterization of central neurocytomas: Potential markers for tumor typing and progression

An emerging consensus on aquaporin translocation as a regulatory mechanism

Aquaporin Expression, Regulation and Function in the Intervertebral Disc

Contact Info

Product

Resources

About