Aquaporin-3 expression in common hyperproliferative skin disorders

Ramadan, Wafaa Mohammad; Gheida, Shereen F.; El-Ashmawy, Amal Ahmad; Shareef, Mohamed

doi:10.1097/01.ewx.0000513084.47849.72

Cited by 4 publications

(3 citation statements)

References 27 publications

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“…Aquaporin-3 (AQP3) is an epidermal water/glycogen channel protein that facilitates skin hydration [ 58 ]. Several studies have found AQP3 expression is down-regulated in psoriatic lesions and is abnormally localised to the keratinocyte cytoplasm, which may contribute to skin barrier disruption and dehydration in psoriasis [ 59 , 60 , 61 ].…”

Section: Barrier Aberration In Psoriasismentioning

confidence: 99%

Skin Barrier Dysregulation in Psoriasis

Andreas

Bereza-Malcolm

Lynch

et al. 2021

IJMS

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The skin barrier is broadly composed of two elements—a physical barrier mostly localised in the epidermis, and an immune barrier localised in both the dermis and epidermis. These two systems interact cooperatively to maintain skin homeostasis and overall human health. However, if dysregulated, several skin diseases may arise. Psoriasis is one of the most prevalent skin diseases associated with disrupted barrier function. It is characterised by the formation of psoriatic lesions, the aberrant differentiation and proliferation of keratinocytes, and excessive inflammation. In this review, we summarize recent discoveries in disease pathogenesis, including the contribution of keratinocytes, immune cells, genetic and environmental factors, and how they advance current and future treatments.

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Section: Barrier Aberration In Psoriasismentioning

confidence: 99%

Skin Barrier Dysregulation in Psoriasis

Andreas

Bereza-Malcolm

Lynch

et al. 2021

IJMS

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“…However, the underlying mechanisms for the enhanced concentration of ROS in cancer cell membranes remain elusive ( Van der Paal et al, 2016 ). Another explanation could be the increased expression of aquaporins (AQPs), a membrane protein family that facilitates the diffusion of water across cellular membranes, in melanoma/non-melanoma cells ( Verkman et al, 2008 ; Ramadan et al, 2017 ). It is shown that various cancer cell lines have expressed elevated levels of certain AQPs ( Shi et al, 2012 ; Papadopoulos and Saadoun, 2015 ; Yan et al, 2015 , 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Insight Into the Molecular Dynamic Simulation Studies of Reactive Oxygen Species in Native Skin Membrane

et al. 2018

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In recent years, the role of reactive oxygen species (ROS) in regulating cancer cell apoptosis, inflammation, cell ischemia, and cell signaling pathways has been well established. The most common sources of intracellular ROS are the mitochondrial electron transport system, NADH oxidase, and cytochrome P450. In this study, we investigated the dynamics and permeability of ROS using molecular dynamics (MD) simulations on native skin-lipid bilayer membranes. Native skin-lipid bilayers are composed of ceramide, cholesterol, and free fatty acid in an almost equal molar ratio (1:1:1). Dynamic distribution studies on ROS, i.e., hydrogen peroxide (H2O2) and O2 (1O2 by analogy), revealed that these species interact with cholesterol as a primary target in lipid peroxidation of the skin-lipid bilayer. Moreover, the permeability of ROS, i.e., H2O2, hydroxyl radicals (HO), hydroperoxy radical (HOO), and O2, along the skin-lipid bilayer was measured using free energy profiles (FEPs). The FEPs showed that in spite of high-energy barriers, ROS traveled through the membrane easily. Breaching the free energy barriers, these ROS permeated into the membrane, inflicting oxidative stress, and causing apoptosis. Collectively, the insight acquired from simulations may result in a better understanding of oxidative stress at the atomic level.

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“…Measuring AQP3 expression in skin proliferative diseases such as squamous cell carcinoma, psoriasis, keratoacanthoma, and seborrheic keratosis showed that AQP3 had a lower expression in patients with these diseases compared to healthy population. Likewise, a negative correlation was found between the degree of differentiation and expression of AQP3 (Ramadan et al, 2017). These results claimed that the role of AQP3 in differentiation is much more important than its role in proliferation.…”

Section: Disease‐based Surveymentioning

confidence: 98%

Aquaporins and diseases pathogenesis: From trivial to undeniable involvements, a disease‐based point of view

Ala

Jafari

Hajiabbasi

et al. 2021

Journal Cellular Physiology

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Aquaporins (AQPs), as transmembrane proteins, were primarily identified as water channels with the ability of regulating the transmission of water, glycerol, urea, and other small-sized molecules. The classic view of AQPs involvement in therapeutic plan restricted them and their regulators into managing only a narrow spectrum of the diseases such as diabetes insipidus and the syndrome of inappropriate ADH secretion. However, further investigations performed, especially in the third millennium, has found that their cooperation in water transmission control can be manipulated to handle other burden-imposing diseases such as cirrhosis, heart failure, Meniere's disease, cancer, bullous pemphigoid, eczema, and Sjögren's syndrome.

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Aquaporin-3 expression in common hyperproliferative skin disorders

Cited by 4 publications

References 27 publications

Skin Barrier Dysregulation in Psoriasis

Skin Barrier Dysregulation in Psoriasis

Insight Into the Molecular Dynamic Simulation Studies of Reactive Oxygen Species in Native Skin Membrane

Aquaporins and diseases pathogenesis: From trivial to undeniable involvements, a disease‐based point of view

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