Aquaporin-2 water channel in developing quail kidney: possible role in programming adult fluid homeostasis

Nishimura, Hiroko; Yang, Yimu; Lau, Keith K.; Kuykindoll, Rhonda J.; Fan, Zheng; Yamaguchi, Kensei; Yamamoto, Tadashi

doi:10.1152/ajpregu.00163.2007

Cited by 11 publications

(32 citation statements)

References 41 publications

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“…4). Expression continued to increase during the rest of the embryonic and postnatal period in quail kidneys until ∼3 weeks of age [60]. During development, rat kidneys express AQP mRNAs 1, 2, 3, and 4 [76].…”

Section: Aqps During Development and Maturationmentioning

confidence: 93%

“…qAQP2 mRNA hybridization signals were not detectable in mesonephric kidneys at E5 from Japanese quail, while positive hybridization signals were seen in the CDs/ureteric bud-like structures in the deeper area of metanephric kidneys on E10 [60] (Fig. 4).…”

Section: Aqps During Development and Maturationmentioning

confidence: 96%

“…Reproduced with modification from Yang et al [77] (see also for references). Horizontal bars (length of branch) indicate 0.05 for a and 0.1 for b hybridization signals of the riboprobe of qAQP2 mRNA [60] increased after water deprivation/AVT treatment, suggesting that an AQP2 mechanism regulated by ADH/AVT via cAMP exists in quail. A partial amino acid sequence of AQP2 has also been identified in chickens and the transcript of chicken AQP2 was detected only in the kidney [64].…”

Section: Aqp2-homologue Channelmentioning

confidence: 99%

“…In E15 embryos, mesonephric kidneys are scarce; and after hatch, only metanephric kidneys are seen. In metanephros, glomeruli are larger in deeper regions than in superficial regions and the number of glomeruli per kidney increases exponentially during the later embryonic stage and early postnatal days (∼10 days) [60]. Elongation of medullary cones continues ∼4 weeks.…”

Section: Aqps During Development and Maturationmentioning

confidence: 99%

“…The kidney is a primary organ for regulating blood pressure and blood volume homeostasis and may have an essential role in fetal programming of adult diseases [47]. We investigated whether under-nutrition during the embryonic period (5-10% egg white withdrawn) or 48 h food deprivation in newborn Japanese quail retards kidney and AQP2 development and programs impaired volume regulation in adults [60]. In egg white-withdrawn embryos, qAQP2 mRNA expression is initially delayed, then restored; birth weight and hatching rate are lower than in controls.…”

Section: Aqps During Development and Maturationmentioning

confidence: 99%

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Urine concentration and avian aquaporin water channels

Nishimura

2008

Pflugers Arch - Eur J Physiol

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Although birds and mammals have evolved from primitive tetrapods and advanced divergently, both can conserve water by producing hyperosmotic urine. Unique aspects in the avian system include the presence of loopless and looped nephrons, lack of the thin ascending limb of Henle's loop, a corticomedullary osmotic gradient primarily consisting of NaCl without contribution of urea, and significant postrenal modification of final urine. The countercurrent multiplier mechanism operates between the descending and ascending limbs of Henle via recycling of a single solute (NaCl) with no water accompaniment, forming an osmotic gradient along the medullary cone. Bird kidneys and developing rat kidneys share morphological and functional characteristics. Avian kidneys express aquaporin (AQP) 1, 2, and 4 homologues that share considerable homology with mammalian counterparts, but their distribution and function may not be the same. AQP2 expression in Japanese quail (q) evolves in the collecting duct of early metanephric kidneys and continues to increase in intensity and distribution during nephrogenesis and maturation. qAQP2 mRNA and protein are increased by arginine vasotocin (avian ADH), but vasotocin-induced enhancement of cAMP production and water permeability are less marked than in mammalian kidneys. Nephrogenesis is delayed by insufficient nutrition in avian embryos and newborns and results in fewer nephrons and an impaired water balance in adults. Diabetes insipidus quail with homozygous autosomal recessive mutation and an unaffected vasotocin system have low AQP2 expression, underdeveloped medullary cones. Comparative studies will provide important insight into integrative, cellular, and molecular mechanisms of epithelial water transport and its control by humoral, neural, and hemodynamic mechanisms.

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Section: Aqps During Development and Maturationmentioning

confidence: 93%

Section: Aqps During Development and Maturationmentioning

confidence: 96%

Section: Aqp2-homologue Channelmentioning

confidence: 99%

Section: Aqps During Development and Maturationmentioning

confidence: 99%

Section: Aqps During Development and Maturationmentioning

confidence: 99%

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Urine concentration and avian aquaporin water channels

Nishimura

2008

Pflugers Arch - Eur J Physiol

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Control of aquaporin 2 expression in collecting ducts of quail kidneys

Lau

Yang

Cook

et al. 2009

General and Comparative Endocrinology

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Restricted nutrition-induced low birth weight, low number of nephrons and glomerular mesangium injury in Japanese quail

Nishimura

Yaoita

Nameta

et al. 2017

J Dev Orig Health Dis

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Insufficient nutrition during the perinatal period causes structural alterations in humans and experimental animals, leading to increased vulnerability to diseases in later life. Japanese quail, Coturnix japonica, in which partial (8-10%) egg white was withdrawn (EwW) from eggs before incubation had lower birth weights than controls (CTs). EwW birds also had reduced hatching rates, smaller glomeruli and lower embryo weight. In EwW embryos, the surface condensate area containing mesenchymal cells was larger, suggesting that delayed but active nephrogenesis takes place. In mature EwW quail, the number of glomeruli in the cortical region (mm2) was significantly lower (CT 34.7±1.4, EwW 21.0±1.2); capillary loops showed focal ballooning, and mesangial areas were distinctly expanded. Immunoreactive cell junction proteins, N-cadherin and podocin, and slit diaphragms were clearly seen. With aging, the mesangial area and glomerular size continued to increase and were significantly larger in EwW quail, suggesting compensatory hypertrophy. Furthermore, apoptosis measured by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick-end labeling analysis was higher in EwWs than in CTs on embryonic day 15 and postnatal day 4 (D4). Similarly, plasma glucocorticoid (corticosterone) was higher (P<0.01) on D4 in EwW quail. These results suggest that although nephrogenic activity is high in low-nutrition quail during the perinatal period, delayed development and increased apoptosis may result in a lower number of mature nephrons. Damaged or incompletely mature mesangium may trigger glomerular injury, leading in later life to nephrosclerosis. The present study shows that birds serve as a model for 'fetal programming,' which appears to have evolved phylogenetically early.

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Aquaporin-2 water channel in developing quail kidney: possible role in programming adult fluid homeostasis

Cited by 11 publications

References 41 publications

Urine concentration and avian aquaporin water channels

Urine concentration and avian aquaporin water channels

Control of aquaporin 2 expression in collecting ducts of quail kidneys

Restricted nutrition-induced low birth weight, low number of nephrons and glomerular mesangium injury in Japanese quail

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