Aquaporin-2 expression in the kidney and urine is elevated in rats with monocrotaline-induced pulmonary heart disease

Ouyang, Shan; Chen, Wei; Zeng, Gaofeng; Chang-cheng, Lei

doi:10.1177/0300060519894448

Cited by 2 publications

(2 citation statements)

References 22 publications

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“…The tubes were allowed to stand undisturbed for 10 minutes before centrifugation for 20 min to collect the serum. After removing the top layer with a micropipette, the tube was refrigerated at -80 °C, and urea and creatinine tests were conducted [ 23 ].…”

Section: Methodsmentioning

confidence: 99%

Nephroprotective effect of vitamin D Against Levofloxacin-induced renal injury: an observational study

Mhaibes,

Abdul-Wahab

2023

JMedLife

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The pathogenesis of kidney damage involves complicated interactions between vascular endothelial and tubular cell destruction. Evidence has shown that vitamin D may have anti-inflammatory effects in several models of kidney damage. In this study, we evaluated the effects of synthetic vitamin D on levofloxacin-induced renal injury in rats. Forty-two white Albino rats were divided into six groups, with each group comprising seven rats. Group I served as the control (negative control) and received intraperitoneal injections of normal saline (0.5 ml) once daily for twenty-one days. Group II and Group III were treated with a single intraperitoneal dose of Levofloxacin (50 mg/kg/day) and (100 mg/kg/day), respectively, for 14 days (positive control groups). Group IV served as an additional negative control and received oral administration of vitamin D3 (500 IU/rat/day) for twenty-one days. In Group V, rats were orally administered vitamin D3 (500 IU/rat/day) for twenty-one days, and intraperitoneal injections of Levofloxacin (50 mg/kg/day) were administered on day 8 for 14 days. Group VI received oral vitamin D3 supplementation (500 IU/rat/day) for twenty-one days, followed by intraperitoneal injections of Levofloxacin (100 mg/kg/day) on day 8 for fourteen days. Blood samples were collected to measure creatinine, urea, malondialdehyde, glutathione reductase, and superoxide dismutase levels. Compared to the positive control group, vitamin D supplementation lowered creatinine, urea, and malondialdehyde levels, while increasing glutathione reductase and superoxide dismutase levels. Urea, creatinine, and malondialdehyde levels were significantly (p<0.05) higher in rats administered LFX 50mg and 100mg compared to rats given (LFX + vitamin D). The main findings of this study show that vitamin D reduces renal dysfunction, suggesting that vitamin D has antioxidant properties and may be used to prevent renal injury.

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Section: Methodsmentioning

confidence: 99%

Nephroprotective effect of vitamin D Against Levofloxacin-induced renal injury: an observational study

Mhaibes,

Abdul-Wahab

2023

JMedLife

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“…Following an increase in plasma osmolality, the neurohypophysial hormone arginine vasopressin is secreted and binds to arginine vasopressin receptor 2 (AVPR2) in the principal cells of the renal collecting duct. This leads to the insertion of AQP2 in the apical plasma membrane, which is responsible for water reabsorption ( Hj and Th, 2016 ; Ouyang et al, 2020 ). Dysregulation of AQP2 is closely associated with several clinical disorders characterized by disturbances in body water balance, including congenital nephrogenic diabetes insipidus ( Li Q. et al, 2021 ), lithium-induced nephrogenic diabetes insipidus, electrolyte disturbances, acute and chronic renal function failure, ureteral obstruction, nephrotic syndrome, congestive heart failure, and liver cirrhosis ( Kwon et al, 2013 ).…”

Section: Classification Of Aqps and Their Involvement In Different Pa...mentioning

confidence: 99%

Aquaporins: A new target for traditional Chinese medicine in the treatment of digestive system diseases

Huang

Yan

et al. 2022

Front. Pharmacol.

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Aquaporins (AQPs) are a family of transmembrane proteins expressed in various organ systems. Many studies have shown that the abnormal expression of AQPs is associated with gastrointestinal, skin, liver, kidneys, edema, cancer, and other diseases. The majority of AQPs are expressed in the digestive system and have important implications for the physiopathology of the gastrointestinal tract as well as other tissues and organs. AQP regulators can prevent and treat most gastrointestinal-related diseases, such as colorectal cancer, gastric ulcer, and gastric cancer. Although recent studies have proposed clinically relevant AQP-targeted therapies, such as the development of AQP inhibitors, clinical trials are still lacking and there are many difficulties. Traditional Chinese medicine (TCM) has been used in China for thousands of years to prevent, treat and diagnose diseases, and is under the guidance of Chinese medicine (CM) theory. Herein, we review the latest research on the regulation of AQPs by TCMs and their active components, including Rhei Radix et Rhizoma, Atractylodis macrocephalae Rhizoma, Salviae miltiorrhizae Radix et Rhizoma, Poria, Astragali radix, and another 26 TCMs, as well as active components, which include the active components include anthraquinones, saponins, polysaccharides, and flavonoid glycosides. Through our review and discussion of numerous studies, we attempt to explore the regulatory effects of TCMs and their active components on AQP expression in the corresponding parts of the body in terms of the Triple Energizer concept in Chinese medicine defined as “upper energizer, middle energizer, and lower energizer,”so as to offer unique opportunities for the development of AQP-related therapeutic drugs for digestive system diseases.

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Aquaporin-2 expression in the kidney and urine is elevated in rats with monocrotaline-induced pulmonary heart disease

Cited by 2 publications

References 22 publications

Nephroprotective effect of vitamin D Against Levofloxacin-induced renal injury: an observational study

Nephroprotective effect of vitamin D Against Levofloxacin-induced renal injury: an observational study

Aquaporins: A new target for traditional Chinese medicine in the treatment of digestive system diseases

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